Macrophage Molecular Biology

Lead Research Organisation: University of Edinburgh
Department Name: UNLISTED


This project is concerned with establishing procedures to isolated and characterise macrophages from bone marrow and blood of the pig, test responses of these cells to macrophage colony-stimulating factor (CSF-1) and microbial stimuli, and establishing ways of manipulating their gene expression using lentiviruses.
Description This award enabled us to develop a simple culture system to support the production of macrophages from pig bone marrow using CSF1. The method has been widely applied by our own and other groups in Roslin and elsewhere and extended to other species.
Exploitation Route This was a method development project, and the method has been published. We have also produced and commercialised through BioRad, the actor required to grow macrophages (CSF1)
Sectors Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology