SOCGEN: Combining Social Science and Molecular Genetic Research to Examine Inequality and the Life Course

Lead Research Organisation: University of Oxford
Department Name: Sociology

Abstract

Although there has been an explosion in the amount of the data in the UK that contains information that has both social science indicators (e.g., education, social status) and molecular genetic data (data with genetic markers), it has yet to be exploited by social scientists. Knowledge from social scientists about how to properly use this data to answer social science research questions and statistical tools to accommodate social science problems remains underdeveloped. Yet this new data will allow social scientists to examine fundamentally new research questions and has the potential for substantive breakthroughs. For the first time in history social scientists can uncover whether there is a genetic and biological component to many of the behaviours that have until now only largely been attributed to social factors. Increasing studies demonstrate that there is a genetic component to core social science topics such as educational level and wellbeing. There are, however, many pitfalls to conducting this type of research including lack of accessible learning and teaching material aimed at social scientists and appropriate statistical models or robustness checks of existing models.

A primary objective of this project is to bring together substantive social science researchers in the field of inequality and the life course with expertise in statistics, biodemography, and quantitative molecular genetics to develop innovative learning resources, statistical models and packages to address the specific shortcomings in this substantive area of research. Developing accessible teaching resources and tailored statistical models and packages will allow UK social scientists to become trendsetting pioneers in answering new biosocial research questions. This will allow us to convey how insights from molecular genetic data and research can be integrated into life course (and social science) research.

Planned Impact

We have already established strong links with relevant stakeholders in the area of the life course via our FamiliesAndSocieties European Project. This includes patient groups, medical practitioners and policy makers in the UK, but also in Europe and internationally. We would invite a selected number of these stakeholders to the kick-off meeting with our Expert Advisory Group at start of the project to obtain feedback and suggestions regarding our plans. At the end of the project we would also invite several stakeholders to participate in the final workshop and provide comments and with the hope that they are able to take useable ideas back to their own peers, patients or policy forums. The input of these stakeholders was also considered at an early stage while preparing this proposal.

Since we also plan to present our results at conferences where medical practitioners are also present, our research will also impact medical doctors such as our results that examine genetic markers, GxE and understanding complex diseases. Particularly the patient groups and medical practice would be very interested in understanding the mechanisms that lead to certain unequal life course outcomes. By developing further knowledge about how lifestyle and social factors are related to genetic markers, the project can directly improve the health and and well-being of individuals. By informing medical practitioners of our results, the project also has the capacity to change organizational culture and practices.

As outlined in our proposal, our aim is to hold a final workshop at the end of this project with leading scholars in the field in order to highlight the main results of this project. In addition to academics, we will also invite several stakeholders and representatives from the media to comment and report on the event. At this time we will also distribute a summary pamphlet of the project, which will include a basic summary of the project and links to our website.

In order to attract a more general public, we will provide a summary of results in a more general form, producing graphics, but also a list of Frequently Asked Questions, which is useful for journalists and the general public.
The researchers will disseminate the results of their academic findings using several other additional social media mediums. First, our aim is to produce a bi-monthly blog that will rotate amongst the researchers in the project. It will be one that is accessible to a more general public and touches upon the main issues of the project. We will also invite questions and comments from the general public on the website, which we can respond. Second, we aim to set-up a Twitter account and send our results to the broadest audience possible.

We will work closely with the University's press office to provide accessible and timely press releases about work and any outreach activities. As described previously, this will be accompanied with a Frequently Asked Questions document for each article and material that we produce that is written in a way that is accessible to journalists and the general public. A recent blog on human fertility and molecular genetics, for instance, (http://www.openpop.org/?p=1111) gained particular interest and was praised by the journalists discussing our research with us as clear and accessible and coverage in major newspapers (Guardian, The Times, The Independent, New York Times).

Together with the Oxford Research Centre in the Humanities (TORCH) and the Ashmolean University Engagement Programme (http://torch.ox.ac.uk/ashmolean-project-portal), we will aim to develop a project around the Ashmolean's exhibition. The aim of the Oxford project is to link University research to the museum's forthcoming exhibitions. If we did receive the funding, would be able to submit an application, which they consider on a rolling basis. We would also engage in a press release and highlight this outreach activity.
 
Title Public engagement film about recent Nature Genetics article 
Description This is a film posted on youtube that provides an accessible description of our recent publication in Nature Genetics about the genetic loci we isolated related to human reproduction and what it means for individuals and those facing infertility problems. 
Type Of Art Artefact (including digital) 
Year Produced 2016 
Impact This film has been linked to various blogs and been largely tweeted and viewed around a week after it was released around 3,000 times from people around the world. 
URL https://www.youtube.com/watch?v=PWSfWSb5KwE
 
Description After 1 year this project has had several significant acheivements, which we aim to build upon for the remaining period of the project. First, we were able to isolate 12 genetic loci linked to human reproduction and specifically the timing of the age of first birth and the number of children ever born. In many societies, contemporary parents are considerably older than decades before, which has led to an unprecedented growth in infertility to around 10-15% of couples. Our goal was to unite social science, molecular genetic and medical science research on this topic to understand whether there was a genetic component to life course topics such as education, well-being, human reproduction and employment and understand how we could use it to study inequality in the life course.
Second, we isolated biological pathways and functions of the genetic loci which were related to to critical fertility related processes such as: follicle stimulating hormone, estrogen, growth in ovaries, spermatid differentiation, male germ cell development and diseases associated with female infertility (endometriosis, PCOS). This points to further development for the medical sciences and Pharmaceuticals and Medical Biotechnology.
Third, we created what is called a 'polygenic score', which represents our best prediction of each person's reproduction (age at first birth, number of children ever born) based on all of their genetic loci. For social scientists and beyond we offer something that rarely occurs - we introduced an entirely new variable of a genetic polygenic score to measure human reproduction and a new way of theoretically thinking about human reproductive choice and behavior. We also use these measures and others relevant to social science research that were recently discovered in the area of educational attainment and wellbeing to examine their relevance across the life course.
Finally, we have begun working on teaching and learning material describing how to undertake this type of research, with interests for a textbook from many publishers. We will test this textbook and our approach at our summer school June 26-30 2017 in Oxford (www.oxfordsociogenetics.com).

As anticipated, the intial steps of the award have been made, with plans for considerable progress in the second phase of the project. This includes a focus on developing statistical models and packages to work with longitudinal and missing data and models that can take gene and environment interaction into account. To address these questions we have already started to work on additional models and packages and substantive questions related to which genetic factors are relevant in particular socio-historical contexts.
Exploitation Route We anticipate that our findings will not only be interesting to social scientists, but also medical sciences and biologists, and those involved in fertility treatment. In the longer term, our project offers a better understanding of the genetic architecture of human reproductive behavior and its relation to the social environment. It likewise has the potential to enable the discovery of predictors of infertility, which would in turn greatly improve family planning but also increase the effectiveness of costly and invasive ART treatments as well as allow couples to realize their fertility intentions. We also hope to produce a better understanding of the biology of human reproduction, which in turn may provide insights into fundamental biological mechanisms and could have ramifications for the study of many health outcomes, especially the etiology of diseases related to the reproductive tract.
Sectors Education,Healthcare,Government, Democracy and Justice,Pharmaceuticals and Medical Biotechnology
URL http://www.nature.com/ng/journal/v48/n12/full/ng.3698.html
 
Description Particularly the findings from our most recent Nature Genetics (2016) study which isolated 12 genetic loci linked to human reproduction had considerable non-academic impact. The public was very interested in these findings about human reproduction, since they are often linked to infertility issues. Via an accessiable Frequently Asked Questions Document (http://www.sociogenome.com/data/NG2016FAQ/) we were able to reach a wide body of the public and media. The media have reacted very positively with wide coverage of the article, with an altmetric score over 600 and coverage in over 60 international news outlets across the world. We produced an accessible film about the topic (https://www.youtube.com/watch?v=PWSfWSb5KwE) which to date has had 3,500 views. We have also been contacted by patient groups (infertility related) and plan to work together regarding policies and warnings about what genetic tests can and cannot say about successful treatment. We were contacted by commerical companies interested in developing our results, but are currently considering the ethical implications.
First Year Of Impact 2016
Sector Education,Government, Democracy and Justice,Pharmaceuticals and Medical Biotechnology
Impact Types Societal,Policy & public services
 
Description John Fell Fund
Amount £68,263 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2016 
End 03/2018
 
Description NCRM International Visitor Exchange Scheme (IVES)
Amount £10,124 (GBP)
Organisation Economic and Social Research Council (ESRC) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 02/2017 
End 07/2017
 
Description Wellcome Trust Institutional Strategic Support Fund
Amount £67,082 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2016 
End 03/2018
 
Description Genes and Complex Human Phenotypes Workshop 
Organisation Stanford University
Department Division of Infectious Diseases & Geographic Medicine
Country United States of America 
Sector Hospitals 
PI Contribution We joined forces with the Stanford Center for Population Health Sciences and the University of California Berkeley's Center on the Economics and Demography of Aging for a 2 day workshop entitled: Genes and Complex Human Phenotypes Workshop, University of California Berkeley, Berkeley, USA May 26-27, 2016. Core members of the SOCGEN group (M. Mills, D. Steinsaltz, N. Barban, F. Tropf) attended and presented our research in discussion with top scholars in the United States examining this topic. The goal was to have exchange with key US scientists on this topic, including Shirpad Tuljapurka, Daniel Belsky, Kathleen Mullan Harris, Mark Cullen, Ben Domingue, David Rehkopf, Ken Wachter, Dalton Conley, Jeremy Freese and Amal Harrati. Several research ideas have emerged from this exchange including a collaboration of Wachter and Steinsaltz, Conley and Mills, Barban and Tropf and an NCRM visitor exchange visit of Ben Domingue to Oxford (Feb. and June 2017) and another planned visit of David Rehkopf in May 2017. The Agenda of the conference can be found here: https://med.stanford.edu/phs/events/Conference11.html A film of all presentations is also available online.
Collaborator Contribution We joined forces with the Stanford Center for Population Health Sciences and the University of California Berkeley's Center on the Economics and Demography of Aging for a 2 day workshop entitled: Genes and Complex Human Phenotypes Workshop, University of California Berkeley, Berkeley, USA May 26-27, 2016. Core members of the SOCGEN group (M. Mills, D. Steinsaltz, N. Barban, F. Tropf) attended and presented our research in discussion with top scholars in the United States examining this topic. The goal was to have exchange with key US scientists on this topic, including Shirpad Tuljapurka, Daniel Belsky, Kathleen Mullan Harris, Mark Cullen, Ben Domingue, David Rehkopf, Ken Wachter, Dalton Conley, Jeremy Freese and Amal Harrati. Several research ideas have emerged from this exchange including a collaboration of Wachter and Steinsaltz, Conley and Mills, Barban and Tropf and an NCRM visitor exchange visit of Ben Domingue to Oxford and another planned visit of David Rehkopf. The Agenda of the conference can be found here: https://med.stanford.edu/phs/events/Conference11.html A film of all presentations is also available online.
Impact Outcomes from this workshop include: (1) Nature Genetics 2016 paper - workshop was used to gain comments, revisions, discussion (2) PNAS Commentary 2016 paper - workshop was used to discuss ideas for PNAS commentary with Editor Ken Wachter (3) Time used to discuss paper development now submitted - Steinsaltz,D. Andrew Dahl, and Kenneth W Wachter. "Statistical properties of simple random-effects models for genetic heritability". Submitted Electronic Journal of Statistics. bioRxiv: 087304. Nov. 2016. (4) Development of collaborations, which have resulted in proposals and research visit. Ben Domingue (Stanford) was awarded NRCM visiting fellowship to join our group in February and June 2017. David Rehkopf (Stanford) will visit Oxford for collaboration in May 2017. Dalton Conley (Princeton) and Ben Domingue (Stanford) agreed to be course instructors at our NCRM Oxford sociogenetics summer school June 26-30 2017 (www.oxfordsociogenetics.com) Considerable interdisciplinary collaboration was developed with this group with researchers from: sociology, demography, statistics, biology, mathematics, medical sciences.
Start Year 2016
 
Description Genes and Complex Human Phenotypes Workshop 
Organisation University of California
Department University of California, Berkeley
Country United States of America 
Sector Academic/University 
PI Contribution We joined forces with the Stanford Center for Population Health Sciences and the University of California Berkeley's Center on the Economics and Demography of Aging for a 2 day workshop entitled: Genes and Complex Human Phenotypes Workshop, University of California Berkeley, Berkeley, USA May 26-27, 2016. Core members of the SOCGEN group (M. Mills, D. Steinsaltz, N. Barban, F. Tropf) attended and presented our research in discussion with top scholars in the United States examining this topic. The goal was to have exchange with key US scientists on this topic, including Shirpad Tuljapurka, Daniel Belsky, Kathleen Mullan Harris, Mark Cullen, Ben Domingue, David Rehkopf, Ken Wachter, Dalton Conley, Jeremy Freese and Amal Harrati. Several research ideas have emerged from this exchange including a collaboration of Wachter and Steinsaltz, Conley and Mills, Barban and Tropf and an NCRM visitor exchange visit of Ben Domingue to Oxford (Feb. and June 2017) and another planned visit of David Rehkopf in May 2017. The Agenda of the conference can be found here: https://med.stanford.edu/phs/events/Conference11.html A film of all presentations is also available online.
Collaborator Contribution We joined forces with the Stanford Center for Population Health Sciences and the University of California Berkeley's Center on the Economics and Demography of Aging for a 2 day workshop entitled: Genes and Complex Human Phenotypes Workshop, University of California Berkeley, Berkeley, USA May 26-27, 2016. Core members of the SOCGEN group (M. Mills, D. Steinsaltz, N. Barban, F. Tropf) attended and presented our research in discussion with top scholars in the United States examining this topic. The goal was to have exchange with key US scientists on this topic, including Shirpad Tuljapurka, Daniel Belsky, Kathleen Mullan Harris, Mark Cullen, Ben Domingue, David Rehkopf, Ken Wachter, Dalton Conley, Jeremy Freese and Amal Harrati. Several research ideas have emerged from this exchange including a collaboration of Wachter and Steinsaltz, Conley and Mills, Barban and Tropf and an NCRM visitor exchange visit of Ben Domingue to Oxford and another planned visit of David Rehkopf. The Agenda of the conference can be found here: https://med.stanford.edu/phs/events/Conference11.html A film of all presentations is also available online.
Impact Outcomes from this workshop include: (1) Nature Genetics 2016 paper - workshop was used to gain comments, revisions, discussion (2) PNAS Commentary 2016 paper - workshop was used to discuss ideas for PNAS commentary with Editor Ken Wachter (3) Time used to discuss paper development now submitted - Steinsaltz,D. Andrew Dahl, and Kenneth W Wachter. "Statistical properties of simple random-effects models for genetic heritability". Submitted Electronic Journal of Statistics. bioRxiv: 087304. Nov. 2016. (4) Development of collaborations, which have resulted in proposals and research visit. Ben Domingue (Stanford) was awarded NRCM visiting fellowship to join our group in February and June 2017. David Rehkopf (Stanford) will visit Oxford for collaboration in May 2017. Dalton Conley (Princeton) and Ben Domingue (Stanford) agreed to be course instructors at our NCRM Oxford sociogenetics summer school June 26-30 2017 (www.oxfordsociogenetics.com) Considerable interdisciplinary collaboration was developed with this group with researchers from: sociology, demography, statistics, biology, mathematics, medical sciences.
Start Year 2016
 
Description Believe it or not: Timing of your first child may be coded in DNA, 3 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://economictimes.indiatimes.com/magazines/panache/believe-it-or-not-timing-of-your-first-child-m...
 
Description Blog Enrolment as an Excuse? On the Causal Effect of Education on Fertility Postponement 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Accessible Blog - Enrolment as an Excuse? On the Causal Effect of Education on Fertility Postponement
Year(s) Of Engagement Activity 2017
URL http://www.openpop.org/?p=1395
 
Description Blogs with accessible infrographics 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Wrote a blog 'The Causal Effect of a Genetic Liability for Schizophrenia on the Age at First Birth' which sparked discussion and media attention to our 2016 article on this topic.
Year(s) Of Engagement Activity 2016
URL http://www.openpop.org/?p=1348
 
Description DNA Influences The Age At Which People Have Their First Child And The Number Of Children, 1 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.medindia.net/news/healthwatch/dna-influences-the-age-at-which-people-have-their-first-chi...
 
Description DNA May Influence Your Reproductive Decisions, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.philly.com/philly/health/topics/HealthDay716374_20161031_DNA_May_Influence_Your_Reproduct...
 
Description DNA May Influence Your Reproductive Decisions, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://tucson.com/lifestyles/health-med-fit/dna-may-influence-your-reproductive-decisions/article_7a...
 
Description DNA May Influence Your Reproductive Decisions, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://consumer.healthday.com/sexual-health-information-32/childbirth-health-news-126/dna-may-influ...
 
Description DNA May Influence Your Reproductive Decisions, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.doctorslounge.com/index.php/news/hd/67550
 
Description DNA May Influence Your Reproductive Decisions, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.medicinenet.com/script/main/art.asp?articlekey=199494
 
Description DNA May Influence Your Reproductive Decisions, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://www.eheandme.com/news_articles/549677155
 
Description DNA May Influence Your Reproductive Decisions, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://www.drugs.com/news/dna-may-influence-your-reproductive-decisions-63251.html?utm_source=ddc&u...
 
Description DNA May Influence Your Reproductive Decisions, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://health.usnews.com/health-care/articles/2016-10-31/dna-may-influence-your-reproductive-decisio...
 
Description DNA has the code of your reproductivity, 3 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.asianage.com/science-health/dna-has-code-your-reproductivity-676
 
Description DNA may influence when you have kids, and how many, study says, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.ntnews.com.au/news/national/dna-may-influence-when-you-have-kids-and-how-many-study-says/...
 
Description DNA may influence when you have kids, and how many, study says, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.couriermail.com.au/news/national/dna-may-influence-when-you-have-kids-and-how-many-study-...
 
Description DNA may influence when you have kids, and how many, study says, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.heraldsun.com.au/news/national/dna-may-influence-when-you-have-kids-and-how-many-study-sa...
 
Description DNA may influence when you have kids, and how many, study says, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.adelaidenow.com.au/news/south-australia/dna-may-influence-when-you-have-kids-and-how-many...
 
Description DNA may influence when you have kids, and how many, study says, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.geelongadvertiser.com.au/news/national/dna-may-influence-when-you-have-kids-and-how-many-...
 
Description DNA may influence when you have kids, and how many, study says, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.dailytelegraph.com.au/news/dna-may-influence-when-you-have-kids-and-how-many-study-says/n...
 
Description DNA may influence your reproductive decisions, 2 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.health24.com/Medical/Genetics/News/dna-may-influence-your-reproductive-decisions-20161102
 
Description DNA may influence your reproductive decisions, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.upi.com/Health_News/2016/10/31/DNA-may-influence-your-reproductive-decisions/943147796484...
 
Description DNA may play a role in when you choose to have kids, 1 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.cbsnews.com/news/dna-may-play-a-role-in-when-you-choose-to-have-kids/
 
Description DNA may play a role in when you have kids 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://healthmedicinet.com/i/dna-may-play-a-role-in-when-you-have-kids/
 
Description Dina gener kan påverka hur många barn du får, 1 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://sverigesradio.se/sida/artikel.aspx?programid=406&artikel=6553257
 
Description Do Genes Decide When We Have Children?, 3 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.healthcanal.com/genetics-birth-defects/75422-do-genes-decide-when-we-have-children.html
 
Description Entscheiden die Gene, wann wir Kinder kriegen?, 8 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.biermann-medizin.de/fachbereiche/gynaekologie/medizin-forschung/entscheiden-gene-wann-wir...
 
Description Età della prima gravidanza e numero di figli? Si può chiedere anche ai geni, 28 December 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.dica33.it/cont/news/1701/3026/eta-della-prima-gravidanza-numero-figli-puo.asp
 
Description Frequently Asked Questions accessible document for Nature Genetics (2016) article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact We wrote a very accessibel FAQ document that describes our research in lay terms and widely used by journalists, patient groups and the public to understand our Nature Genetics (2016) publication and the implications for human reproduction.
Year(s) Of Engagement Activity 2016
URL http://www.sociogenome.com/data/NG2016FAQ/
 
Description Gene beeinflussen Zeitpunkt des Kinderkriegens, 2 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.scinexx.de/wissen-aktuell-20786-2016-11-02.html
 
Description Generna påverkar när vi får första barnen - och hur många det blir, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.forskning.se/2016/10/31/generna-paverkar-nar-vi-far-forsta-barnen-och-hur-manga-det-blir/
 
Description Genes affect when we have children and family size, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.mynewsdesk.com/uk/uu/pressreleases/dna-linked-with-the-age-at-which-we-have-our-first-chi...
 
Description Genome-wide analysis identifies 12 loci influencing human reproductive behavior, 1 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.bioportfolio.com/news/article/2891063/Genome-wide-analysis-identifies-12-loci-influencing...
 
Description Hoeveel kinderen jij krijgt, wordt ook bepaald door je DNA, 1 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.rtlnieuws.nl/gezin/hoeveel-kinderen-jij-krijgt-wordt-ook-bepaald-door-je-dna
 
Description How DNA might affect our reproductive choices, 1 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.medicalnewstoday.com/articles/313828.php
 
Description How Many Kids Will You Have? Your DNA Knows, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.msn.com/en-ph/health/medical/how-many-kids-will-you-have-your-dna-knows/ar-AAjEYiZ
 
Description How Many Kids You'll Have (and When) May Be Written in Your DNA, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://www.yahoo.com/beauty/many-kids-ll-may-written-193803366.html?src=rss
 
Description Il DNA ti dice a che età partorirai e quanti figli avrai, ecco come, 2 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://scienze.fanpage.it/il-dna-ti-dice-a-che-eta-partorirai-e-quanti-figli-avrai-ecco-come/
 
Description L'età giusta per diventare genitori? E' scritta nel Dna , 3 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.msn.com/it-it/salute/pregnancyparenting/l%E2%80%99et%C3%A0-giusta-per-diventare-genitori-...
 
Description L'età giusta per diventare genitori? E' scritta nel Dna, 3 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.ok-salute.it/sessualita/leta-giusta-diventare-genitori-scritta-nel-dna/
 
Description La fertilità è scritta (anche) nei nostri geni, 5 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.agoravox.it/La-fertilita-e-scritta-anche-nei.html
 
Description Media interview The Guardian Jan 16 2017 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview and comment by Melinda C. Mills on recent article in PNAS, Natural selection making 'education genes' rarer
Year(s) Of Engagement Activity 2017
URL https://www.theguardian.com/science/2017/jan/16/natural-selection-making-education-genes-rarer-says-...
 
Description New genetic variants found to influence fertility, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article blog.
Year(s) Of Engagement Activity 2016
URL https://blog.23andme.com/23andme-research/waiting-on-baby/
 
Description Our genes define the age at which we have our first child, 3 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://med.news.am/eng/news/12283/our-genes-define-the-age-at-which-we-have-our-first-child.html
 
Description Our genes influence when and how many children we have, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.ibtimes.co.uk/family-size-age-birth-first-child-influenced-by-our-genes-1589110
 
Description Press Release Nature Genetics article in 8 languages 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact We translated a short press release describing our recent Nature Genetics (2016) publication into a 2-page press release and summary available in: English, Chinese, Arabic, German, French, Dutch, Swedish and Italian.
As a result the article received considerable attention by world media. At the time of writing this, the article had a altmetric score of 631, which is in the 98 percentile (ranked 1st) of the 78 tracked articles of a similar age in Nature Genetics. The article was picked up by over 70 news outlets world wide, including all major news outlets.
The article was also widely picked up by the Asian and Arabic audience and covered as an Editorial In Nature Middle East (http://www.natureasia.com/en/nmiddleeast/article/10.1038/nmiddleeast.2016.198)
Year(s) Of Engagement Activity 2016
URL http://www.sociogenome.com/data/FAQlanguages/
 
Description Ten New Genetic Regions Linked to Human Reproductive Behavior, 1 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.sci-news.com/genetics/genetic-regions-human-reproductive-behavior-04326.html?utm_source=f...
 
Description The genes that decide what age a woman gives birth: Variations ensure a woman remains fertile for longer, 3 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.dailymail.co.uk/sciencetech/article-3892048/The-genes-decide-age-woman-gives-birth-Variat...
 
Description Timing of your first child may be coded in DNA, 2 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.newindianexpress.com/lifestyle/health/2016/nov/02/timing-of-your-first-child-may-be-coded...
 
Description Timing of your first child may be coded in DNA, 2 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://in.news.yahoo.com/timing-first-child-may-coded-dna-102405708.html
 
Description Timing of your first child may be coded in DNA, 2 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.business-standard.com/article/news-ians/timing-of-your-first-child-may-be-coded-in-dna-11...
 
Description Timing of your first child may be coded in DNA, 2 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.freepressjournal.in/webspecial/timing-of-your-first-child-may-be-coded-in-dna/965744
 
Description Twelve DNA areas 'linked with the age at which we have our first child and family size' , 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://www.eurekalert.org/pub_releases/2016-10/uoo-1da102816.php
 
Description Twelve DNA areas 'linked with the age at which we have our first child and family size', 1 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.healthcanal.com/genetics-birth-defects/75377-twelve-dna-areas-linked-with-the-age-at-whic...
 
Description Twelve DNA areas 'linked with the age at which we have our first child and family size', 1 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://www.sciencedaily.com/releases/2016/11/161101104311.htm
 
Description Twelve DNA areas 'linked with the age at which we have our first child and family size, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://medicalxpress.com/news/2016-10-twelve-dna-areas-linked-age.html
 
Description Want to know how many kids you will have? Ask your DNA, 2 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.dnaindia.com/scitech/report-want-to-know-how-many-kids-you-will-have-ask-your-dna-2269560
 
Description When Will I Have A Baby? These Strands Of DNA May Explain When & How Many Children You'll Have, 8 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL https://www.bustle.com/articles/193861-when-will-i-have-a-baby-these-strands-of-dna-may-explain-when...
 
Description When we have kids, and how many, may be partly genetic, 2 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.foxnews.com/health/2016/11/02/when-have-kids-and-how-many-may-be-partly-genetic.html
 
Description Your DNA Plays A Role In How Many Children You'll Have, And When: 12 Genetic Areas Associated With Reproduction, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.medicaldaily.com/your-dna-plays-role-how-many-children-youll-have-and-when-12-genetic-are...
 
Description Your DNA Plays A Role In How Many Children You'll Have, And When: 12 Genetic Areas Associated With Reproduction, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article blog.
Year(s) Of Engagement Activity 2016
URL http://www.medicaldaily.com/your-dna-plays-role-how-many-children-youll-have-and-when-12-genetic-are...
 
Description Your DNA may predict how many kids you will have, 3 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.siasat.com/news/dna-may-predict-many-kids-will-1056294/
 
Description Your DNA will decide how many kids you'll have, 3 November 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.poandpo.com/in-sickness-and-health/your-dna-will-decide-how-many-kids-youll-have-31120162...
 
Description expert reaction to paper identifying 12 genetic loci linked to human reproductive behaviour, 31 October 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Nature Genetics 2016 article media mention.
Year(s) Of Engagement Activity 2016
URL http://www.sciencemediacentre.org/expert-reaction-to-paper-identifying-12-genetic-loci-linked-to-hum...