Calcium Channels and Cardiac arrhythmogenesis in the gene-targeted mouse

Lead Research Organisation: University of Cambridge
Department Name: Physiology

Abstract

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Publications


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Balasubramaniam R (2004) Nifedipine and diltiazem suppress ventricular arrhythmogenesis and calcium release in mouse hearts. in Pflugers Archiv : European journal of physiology
Balasubramaniam R (2005) Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. in American journal of physiology. Heart and circulatory physiology
Head CE (2005) Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice. in Journal of cardiovascular electrophysiology
Killeen MJ (2007) Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart. in Acta physiologica (Oxford, England)
 
Description Wellcome Trust TMAT Scheme
Amount £50,000 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2010 
End 10/2013
 
Title Transgenic animal model for cardiac arrhythmic disease 
Description Transgenic animal model for catecholaminergic polymorphic ventricular tachycardia 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2010 
Provided To Others? Yes  
Impact New insights identifying arrhythmic substrate in CPVT 
 
Description Na channel expression in Na channel haploinsufficient hearts 
Organisation Imperial College London (ICL)
Department Imperial College of Science Technology and Medicine (ICSTM)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Na+ channel expression in the Scn5a+/- hearts.
Collaborator Contribution Expertise in cell isolation
Impact Research papers on the Scn5a+/- cardiac system
Start Year 2011
 
Description Studies on atrial arrhythmia 
Organisation University of Manchester
Department School of Materials Manchester
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Work with Manchester extending ideas to atrial arrhythmogenesis
Collaborator Contribution Learning new molecular biology techniquesnew molecular biology techniques
Impact See list of publications.
Start Year 2009
 
Description Studies on atrial arrhythmia 
Organisation University of Manchester
Department School of Materials Manchester
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Work with Manchester extending ideas to atrial arrhythmogenesis
Collaborator Contribution Learning new molecular biology techniquesnew molecular biology techniques
Impact See list of publications.
Start Year 2009
 
Title Electrogram fractionation analysis 
Description We are being considered by Imperial Innovations for possible support in connection with the development of diagnostic equipment for the clinical diagnosis of the risk of sudden cardiac death 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2006
Development Status Actively seeking support
Impact Possible future means of determining indications for defibrillator pacemaker implantation 
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Around 15 individuals attended demonstrations made in the course of the day.

Increased public interest in those who attended
Year(s) Of Engagement Activity 2007
 
Description rotary club 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation of clinical implications for sudden cardiac death of our physiological work.

Return invitation was made for future presentation occasion.
Year(s) Of Engagement Activity 2007