The involvement of M-LDH physically associated with sarcolemmal KATP channel subunits in cardioprotection

Lead Research Organisation: University of Dundee
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications


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Budas GR (2006) 3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Du Q (2006) Overexpression of SUR2A generates a cardiac phenotype resistant to ischemia. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Faghihi M (2008) Mg2+ protects adult beating cardiomyocytes against ischaemia. in International journal of molecular medicine
Jovanovic A (2009) SURA2 targeting for cardioprotection? in Current opinion in pharmacology
Jovanovic A (2006) Ageing, gender and cardiac sarcolemmal K(ATP) channels. in The Journal of pharmacy and pharmacology
Jovanovic N (2006) An unexpected negative inotropic effect of prostaglandin F2alpha in the rat heart. in Prostaglandins & other lipid mediators
Jovanovic S (2006) High glucose protects single beating adult cardiomyocytes against hypoxia. in Biochemical and biophysical research communications
 
Description Citations in reviews published in clinical journals
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical reviews
 
Description BHF funding (Non-channel aspects of sarcolemmal KATP channels and cardioprotection)
Amount £154,293 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2006 
End 03/2010
 
Description BHF funding (Overexpression of SUR2A as a strategy to counteract ageing-induced increase in myocardial susceptibility to ischaemia)
Amount £136,679 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 09/2008 
End 08/2011
 
Description IES SUR2B-mediated cardioprotection
Amount £170,000 (GBP)
Funding ID PG/15/28/31384 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2016 
End 01/2019
 
Description Increased expression of SUR2A as a strategy to counteract ageing-induced decrease in cardiac output and physical endurance
Amount £95,646 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2009 
End 01/2011
 
Title Annexin-luciferase 
Description This is annexin-luciferase subcloned into adenoviral vector. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact This can be used to specifically measure subsarcolemmal level of ATP. 
 
Title Mutants of M-LDH 
Description These are mutant/truncated forms of M-LDH subcloned into adenoviral vectors. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact These mutants are useful tool when assesment of any physiological role of M-LDH is required. 
 
Description Cardioprotection afforded by AMPK 
Organisation Harvard University
Department Harvard Medical School
Country United States of America 
Sector Academic/University 
PI Contribution We have designed and executed the study, and analysed and distributed the data.
Collaborator Contribution The Partner has provided transgenic mice for our use and has contributed to data analysis and distribution.
Impact This collaboration has resulted in a publication (pubmed No 17044064)
 
Description Cardioprotection afforded by LKB 
Organisation University of Dundee
Department College of Life Sciences
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution We have contributed to the execution of the study, data analysis and data distribution.
Collaborator Contribution The partner has contributed to the study design, execution, data analysis and data distribution.
Impact The collaboration has resulted in publication (pubmed No 16332922). In addition, it has resulted a Project Grant awarded by the British heart Foundation.
Start Year 2006
 
Description Cardioprotection afforded by PDK1 
Organisation Medical Research Council (MRC)
Department MRC Protein Phosphorylation Unit
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution We conducted a study using transgenic animals from our partner.
Collaborator Contribution The partners provided transgenic animals allowing us to perform this research.
Impact Publication 17077284 has resulted from this collaboration.
 
Description Regulation of blood pressure by WNK-activated SPAK kinase 
Organisation Medical Research Council (MRC)
Department MRC Protein Phosphorylation Unit
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution We have contributed to all aspects of this study including performing telemetry experiments on transgenic mice.
Collaborator Contribution We got transgenic mice to perform this research.
Impact Publication 20091762 resulted from this collaboration.
Start Year 2007
 
Description Public Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This was a public lecture aimed on lay audience that come all over Scotland. Among others, results from this MRC study were also presented.

The lecture was received very well and rose a lot of interest.
Year(s) Of Engagement Activity 2007
 
Description ResearchGate 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact >6000 people viewed my publications and >1000 people downloaded my papers.

Increased dissemination of information stemming for AJ work.
Year(s) Of Engagement Activity 2013,2014
URL https://www.researchgate.net/profile/Aleksandar_Jovanovic6/info?ev=prf_info
 
Description University of Dundee website 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The results obtained from this study are on the University of Dundee website.

The results can be viewed by anybody with the internet access.
Year(s) Of Engagement Activity 2006,2007,2008,2009