The role of monocarboxylate transporter 8 during human placental development in normal and IUGR pregnancies

Lead Research Organisation: University of Birmingham
Department Name: Clinical and Experimental Medicine

Abstract

There is a link between mild underactive thyroid gland activity in pregnant women and delayed mental development in offspring. Further investigation suggests that
maternal thyroid hormone (TH) has a direct effect on the baby’s brain development. This would rely on a well-functioning placenta to transport TH from the mother to the baby. Placental development itself is also influenced by TH, including a critical stage when the blood vessels within the wall of the womb are invaded by placental cells in order to form an effective placenta for exchange of essential factors between the mother and baby. In abnormal pregnancies where babies are not growing well (IUGR), impaired growth often stems from disruptions in placental development. Indeed, disorders of the thyroid gland in women are associated with an increased risk of placental disorders such as IUGR as
well as miscarriages, stillbirths and placental bleeding. Currently, our understanding of how the placenta transports TH and how the development of the placenta is affected by TH is very poor. Although the level of TH in the mother’s blood is a crucial factor, there are other factors which can modulate the effects of TH. One of these factors includes a protein found on cell surfaces called MCT8, which is a potent transporter of TH into cells. We aim to clarify the role of MCT8 within the placenta by studying its presence in human placenta and investigating differences between normal and IUGR pregnancies. We also propose to assess how MCT8 affects the properties of placental cells. Worldwide, disruptions in thyroid gland activity during pregnancy and IUGR are common findings, thus this proposed research would have widespread implications.

Technical Summary

Studies investigating the link between maternal thyroid status and neurodevelopmental delay in offspring suggest a direct effect of maternal thyroid hormone (TH) on fetal brain development, which would rely on a well-functioning placenta for transplacental supply of TH. Placental development, including the trophoblastic invasion of the uterine spiral arteries to transform them into high-flow low-resistance vessels for effective maternal-fetal exchange, is itself TH-responsive as evidenced by in-vitro trophoblast studies. However, the molecular mechanisms mediating these processes remain poorly understood. Whilst circulating maternal THs are the major determinants of transplacental fetal TH supply and placental cell supply of the active ligand, triiodothyronine (T3), other factors modulate them including the plasma membrane transport of TH, the expression of iodothyronine deiodinase enzymes and thyroid hormone receptors (TRs). Intrauterine growth restriction (IUGR) contributes significantly to perinatal and neonatal mortality and morbidity. IUGR is associated with fetal hypothyroxinaemia and is accompanied by malplacentation with at least 50% of spiral arteries remaining ?untransformed?.
Hypothesis:
1) Monocarboxylate transporter 8 (MCT8), the most powerful TH plasma membrane transporter, plays an important role in both the transplacental transport of TH and TH-dependent placental development.
2) In the pathological state of IUGR, increased MCT8 and TR expression occurs as a compensatory mechanism attempting to facilitate TH action in trophoblasts.
Key experimental aims:
1) to define the gestational ontogeny and cellular localisation of MCT8, as well as its co-localisation with deiodinases and TRs in human villous placenta and placental bed from the first, second and third trimesters of pregnancy. We will compare differences between IUGR and normal placenta in the third trimester.
2) to investigate whether MCT8 transports factors in addition to TH (as suggested by observations of MCT8 in neurodevelopment).
3) to assess the effects of the level of MCT8 expression on the proliferation, survival and uterine invasion properties of primary cytotrophoblasts and extravillous trophoblasts.
4) to compare TH transport and functional characteristics [as in (3)] of primary cytotrophoblast from IUGR placenta with those from normal placenta.
5) to use gene arrays to identify thyroid hormone responsive genes and their downstream gene transcription effects in primary cytotrophoblasts, as well as assessing the broader T3-independent response modulated by MCT8 effects.
Conclusion:
These experiments will clarify the role of MCT8 in villous and extravillous trophoblasts, and how alterations in the level of MCT expression can affect placental development.

Publications


10 25 50
Pemberton HN (2007) Separase, securin and Rad21 in neural cell growth. in Journal of cellular physiology
 
Description Research cited in reviews written for clinicians - brain
Geographic Reach North America 
Policy Influence Type Citation in clinical reviews
Impact The clinical significance of research findings of thyroid hormone receptors and deiodinases in human fetal brain is discussed in two reviews targetting both practising Obstetricians and Endocrinologists. 1. Maternal thyroid hormones and fetal brain development. Current Opinion in Diabetes and Endocrinology (2005) 12(1):23-30. 2. Thyroid hormones in fetal central nervous system development. Fetal and Maternal Medicine Reviews (2003) 14: 177-208. 3. Thyroid hormones in pregnancy and the fetus. (2002) Chapter 6, pp 75-101; Progress in Obstetrics and Gynaecology (Volume 15) Churchill and Livingston, UK.; Increasing awareness of laboratory based findings amongsts clinicians and the impact on health care. This has indirectly led to the development of clinical guidelines for management of thyroid disease in pregnancy, details given in a separate outcome measure.
 
Description Research cited in reviews written for clinicians - placenta
Geographic Reach UK 
Policy Influence Type Influenced training of practitioners or researchers
Impact Our papers on deiodinases (PMID 12970328) and MCT8 (PMID 16731778) expression in the human placenta has been cited in several review articles including: 1. The role of the placenta in thyroid hormone delivery to the fetus. Nature Clinical Practice Endocrinology & Metabolism 2009. (PMID 19079273) 2. Placental transport of thyroid hormone. Best Pract Res Clin Endocrinol Metab. 2007;21(2):253-64 (PMID 17574007) ; Increasing awareness of laboratory based findings amongsts clinicians and the impact on health care.
URL http://europepmc.org/abstract/MED/12970328
 
Description Action Medical Research project grant
Amount £182,012 (GBP)
Funding ID 1949 
Organisation Action Medical Research 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2012 
End 01/2015
 
Description Action Medical Research, Project Grant
Amount £105,970 (GBP)
Organisation Action Medical Research 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2008 
End 11/2010
 
Description BTF Project Grant
Amount £10,000 (GBP)
Organisation British Thyroid Foundation (BTF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2010 
End 12/2010
 
Description Birmingham Children's Hospital Research Foundation mall Project grant
Amount £70,000 (GBP)
Organisation BCH Charities 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2012 
End 01/2012
 
Description EME clinical trial
Amount £1,200,000 (GBP)
Organisation Medical Research Council (MRC) 
Department Efficacy and Mechanism Evaluation (EME) Programme
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 07/2011 
End 07/2015
 
Description MRC DTA PhD studentship
Amount £50,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2008 
End 11/2009
 
Description Project Grant WoW
Amount £150,000 (GBP)
Organisation Wellbeing of Women 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2009 
End 09/2012
 
Description Springboard Fellowship Birmingham Women's Hospital R&D
Amount £45,000 (GBP)
Organisation BCH Charities 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 09/2011 
End 09/2012
 
Description Travel Award
Amount £1,000 (GBP)
Organisation International Federation of Placenta Associations (IFPA) 
Sector Charity/Non Profit
Country Global
Start 09/2008 
End 09/2008
 
Title Amaxa nucleofection for trophoblasts 
Description Amaxa nucleofection for primary cytotrophoblasts and choriocarcinoma cell lines: Cultures of primary cytotrophoblast had been notoriously difficult to transfect. We have successfully established the technique of Amaxa electroporation for gene transfection and silencing in our primary cytotrophoblast cultures. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact We can now study for the first time the impact of over and under expression of a gene of interest in primary cytotrophoblast cultures in vitro. 
 
Title Human fetal brain biopsies 
Description We have a collection of fresh frozen biopsies of human fetal cerebral cortex from 6 weeks to 20 weeks gestation (about 70 samples) in our -80C freezer. All our samples are obtained from surgical terminations of pregnancies which eliminates the influence of termination-inducing drugs. The collection occurred between 1997 and 2001. 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact We have a peer-reviewed publication arising from this brain collection: 1. Expression of thyroid receptor isoforms in the human fetal central nervous system and the effects of intrauterine growth restriction. Clin Endocrinol (Oxf). 2000 Oct;53(4):469-77 (PMID 11012572). 2. Early expression of thyroid hormone deiodinases and receptors in human fetal cerebral cortex. Developmental Brain Research 2002, 138: 109-16 (PMID 12354639). 3. A potential role for PTTG/securin in the developing human fetal brain. FASEB J. 2003; 17(12):1631-9 (PMID 12958169). 4. Separase, securin and Rad21 in neural cell growth. Journal of Cellular Physiology 2007, 213(1):45-53 (PMID 17450531). Other new data has been presented orally at international conferences (Expression of thyroid hormone transporters in human fetal brain. The Medical Research Society Meeting for Clinician Scientists, RCP, London, February 2008, and the 55th annual scientific meeting of the Society for Gynecologic Investigations, San Diego, March 2008. Reproductive Sciences Vol. 15 No. 2 Supp. p68A, 26) and manuscripts for publication are being written currently. A co-investigator presented a Visiting Professorial Lecture at the University of Hong Kong on "The role of thyroid hormones in fetal brain development" in December 2007. It has allowed us produce highly novel data describing the expressional ontogeny of several genes which has increased our understanding of the role played by thyroid hormones and different regulators of their actions during the course of development in the fetal brain. This has made an important contribution to the international debate and the recent clinical guidelines on screening for and optimising the treatment of maternal hypothyroidism from early pregnancy to reduce the risk of neurodevelopmental delay in the offspring. 
URL http://europepmc.org/abstract/MED/11012572
 
Title Human placental collection 
Description We have a collection of fresh frozen biopsies of normal human villous placenta ranging from 6 weeks gestation to term (150 samples) as well as placenta from intrauterine growth restricted pregnancies and pregnancies complicated by pre-eclampsia (about 30 samples) in our -80C freezer. All our samples are obtained from either surgical terminations of pregnancies or non-labouring caesarean sections which eliminates the influence of termination-inducing drugs and hormonal changes during labour. The collection began in 1997 and is still on-going. It has involved a lot of researcher and clinician time in identifying suitable samples and collecting relevant clinical information. 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact We have numerous peer-reviewed publications arising from this placental collection. It has allowed us to describe the expressional ontogeny of numerous genes and to assess the changes occuring in pathological pregnancies which has increased our understanding of the role played by different hormones in the placenta. Publications: 1. Circulating thyroid hormone concentrations and placental thyroid hormone receptor expression in normal human pregnancy and pregnancy complicated by intrauterine growth restriction (IUGR). J Clin Endocrinol Metab. 1998; 83(8):2964-71 (PMID 9709977). 2. Ontogeny of hepatocyte growth factor (HGF) and its receptor (c-met) in human placenta: reduced HGF expression in intrauterine growth restriction. Am J Pathol. 1998;153(4):1139-47 (PMID 9777945). 3. Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms. J Clin Endocrinol Metab. 2001; 86(10):4979-83 (PMID 11600574). 4. Expression of 11 beta-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies. Mol Hum Reprod. 2001 Apr;7(4):357-63 (PMID 11279298). 5. The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua. Am J Pathol. 2002;161(1):105-14 (PMID 12107095). 6. Placental iodothyronine deiodinase expression in normal and growth-restricted human pregnancies. J Clin Endocrinol Metab. 2003; 88(9):4488-95 (PMID 12970328) . 7. The use of laser capture microdissection (LCM) and quantitative polymerase chain reaction to define thyroid hormone receptor expression in human term placenta. Placenta. 2004; 25(8-9):758-62 (PMID 15450397). 8. Monocarboxylate transporter 8 expression in the human placenta: the effects of severe intrauterine growth restriction. Journal of Endocrinology 2006; 189(3): 465-71 (PMID 16731778). Abstracts: The Ontogenic Expression of Thyroid Hormone Transporters (MCT10, LAT1, LAT2, OATP4A1) In Human Placenta And Changes With Intrauterine Growth Restriction (IUGR). Oral presentation at The Blair Bell Research Society Meeting, Derby, June 2007 and the 78th American Thyroid Association Meeting, New York, 2007. Thyroid 17 Supp.1: S-106. Poster presentation at the International Federation of Placental Associations, Kingston, Ontario, 2007. Placenta 28: A.38, A5.12. paper submitted for publication. Co-investigator invited to give a Keynote Lecture at the Society of Endocinology meeting, Kensington. London in November 2006 on "The Placenta as a thyroid responsive organ". 
URL http://europepmc.org/abstract/MED/9709977
 
Title Production of MCT8 antibody 
Description The MCT8 protein has been a very difficult protein to develop highly specific antibodies against. We have successfully produced our own specific MCT8 antibody which we have used successfully for a range of applications including Western immunoblottting, immunohistochemistry and FACS. 
Type Of Material Antibody 
Provided To Others? No  
Impact Manuscript using this antibody is in preparation. 
 
Description Erasmus Medical School 
Organisation Erasmus University Rotterdam (Erasmus Universitair Medisch Centrum EUR)
Department University Medical Center
Country Netherlands, Kingdom of the 
Sector Hospitals 
PI Contribution access to data
Collaborator Contribution Intellectual contribution and shared expertise
Impact Co-author on publications PMID 16731778,12970328, 12844347, 12354639. Collaborator on Action medical Research Project Grant (2008-2010, £105k on MCT10 in placenta).
 
Description Jena, Germany 
Organisation Leibniz Association
Department Leibniz Institute for Age Research
Country Germany, Federal Republic of 
Sector Public 
PI Contribution Currently performing analysis on mouse placentae from knock-out mouse model
Collaborator Contribution Providing placenta from MCT8 knock out mouse model for further investigation
Impact Project grant from British Thyroid Foundation Jan-Dec 2010
Start Year 2007
 
Description Newcastle University 
Organisation Newcastle University
Department Institute of Cellular Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution access to new data and authorship of publications.
Collaborator Contribution They have performed immunohistochemical studies in the placenta and trained staff from our group in new techniques. They are co-applicants on a grant awarded by the Wellbeing of Women on thyroid hormone effects in decidua. They are co-authors on recent Placenta publication.
Impact Co-authors on numerous publications (PMID: 16731778, 17911392, 16957024, 15598697, 15331405, 15219879 , 12970328, 12958169, 12107095, 20167367) Project grant from Wellbeing of Women, 2009-2012, £150k.
 
Description St. George's University of London 
Organisation St George's University of London
Department Developmental and Endocrine Signalling Centre
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution access to data
Collaborator Contribution Training of staff in new techniques. Supply of an immortalised cell line.
Impact Co-authors on publication PMID:15598697.
 
Description UCL 
Organisation University College London (UCL)
Department UCL Institute for Women’s Health
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution To assess relationship between IUGR and thyroid status.
Collaborator Contribution To supply samples from a guinea pig model of IUGR.
Impact none yet.
Start Year 2012
 
Description University Hospital Zurich 
Organisation University of Zurich (Universität Zürich UZH)
Country Switzerland, Swiss Confederation 
Sector Academic/University 
PI Contribution access to data
Collaborator Contribution provided antibodies for research
Impact Co-author on a recently published paper (20167367) and on another submitted paper.
Start Year 2007
 
Description University of Dundee 
Organisation University of Dundee
Department College of Life Sciences
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution access to data
Collaborator Contribution Provided antibodies for research. Co author on a paper.
Impact Co-author on a Placenta paper (20167367).
Start Year 2007
 
Description University of Manchester 
Organisation University of Manchester
Department School of Medicine Manchester
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution access to data
Collaborator Contribution Training of staff in new techniques
Impact Collaborator on a Action Medical Research Grant project grant
Start Year 2006
 
Description University of Zurich 
Organisation University of Zurich (Universität Zürich UZH)
Country Switzerland, Swiss Confederation 
Sector Academic/University 
PI Contribution access to data
Collaborator Contribution Prof Verrey has provided us with antibodies for lab work. Shared expertise on MCT10.
Impact He is a collaborator on Action medical Research Project Grant (2008-2010, £105k on MCT10 in placenta). Co-author on a placenta paper (20167367).
Start Year 2007
 
Description 2nd Endocrinology MA Healthcare Conference, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact A talk on "Hypothyroidism and subclinical thyroid dysfunction in pregnancy" was presented to about 50 Endocrinologists, Geriatricians, GPs and specialist trainees with useful discussions afterwards.

Hopefully change of clinical practice in other parts of the country.
Year(s) Of Engagement Activity 2011
 
Description 61st British Thyroid Association annual meeting 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact 61st British Thyroid Association annual meeting, London, "The Physiology of Maternal and Foetal Thyroid Function", December 2012.

Appreciative audience
Year(s) Of Engagement Activity 2012
 
Description American Thyroid Association annual meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Health Care professionals and basic science researchers from many countries participated.

Presentation kindled lots of interest in subject.
Year(s) Of Engagement Activity 2007,2009
 
Description Annual Refresher in Primary Maternity Care, Toronto 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact 10th Annual Refresher in Primary Maternity Care, Toronto, "Managing Thyroid Problems in Pregnancy", May 2012.

Appreciative audience
Year(s) Of Engagement Activity 2012
 
Description Blair Bell Research Society meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presented research on Vitamin D and pre-eclampsia

Good discussion
Year(s) Of Engagement Activity 2007,2012
 
Description British Endocrine Society annual meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact A talk on "Hypothyroidism and Euthyroid TPO positivity in pregnancy" was given in a pregnancy symposium to a few hundred Endocrinologists, allied professionals and basic scientist.

More invitations to speak at different meetings including lay audiences.
Year(s) Of Engagement Activity 2011
 
Description British Endocrine Society meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Health professionals
Results and Impact Basic science and clinical professionals from around Uk attended.

Informed health care professionals of advances in basic science in their field.
Year(s) Of Engagement Activity 2009
 
Description British Maternal and Fetal Medicine Society meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Health professionals
Results and Impact Hundreds of Obstetricians from Uk and Ireland attended.

In each of those meetings different oral presentations and poster presentations were presented by our research team.
Year(s) Of Engagement Activity 2009,2012,2013
 
Description British Thyroid Foundation local meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact About 15 Lay people, members of the local Birmingham BTF group attended to hear and discuss thyroid disorders in pregnancy.

Invitations to other BTF groups across the UK.
Year(s) Of Engagement Activity 2011
 
Description British Thyroid Foundation, Milton Keynes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact British Thyroid Foundation, Milton Keynes meeting, "How do hyperthyroidism and hypothyroidism affect pregnancy outcomes?", December 2011.

Good discussion afterwards
Year(s) Of Engagement Activity 2012
 
Description Graduate School Festival of Research and Enterprise, December 2007 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact graduate students from across the university attended

Won 3rd prize in poster presemtation.
Year(s) Of Engagement Activity 2007
 
Description International Federation of Placenta Associations Meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Placentologists from around the world gathered for discussions.

our team presented a fairly new aspect of placentaology to the field.
Year(s) Of Engagement Activity 2007,2008
 
Description International Thyroid Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Several hundred clinicians and basic science researchers in the field of Thyroidalogy from all continents of the world met in Paris for the 14th ITC Meeting. A talk on "Thyroid hormone transport across the placenta" was given as part of a pregnancy symposia. The audience was more than expected for the auditorium and an additional auditorium with video relay had to be opened. There was much discussion afterwards.

Closer discussion with other international research group working in the area.
Year(s) Of Engagement Activity 2010
 
Description International symposium, Riga 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Invited lecture to clinicians and scientists gven at the International symposium on Thyroid Hormone Action, Riga.

None
Year(s) Of Engagement Activity 2008
 
Description Iodine Status In The UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Supporters
Results and Impact Iodine Status In The UK - The Way Forward: joint ICCIDD/BTF/BTA meeting, London, "Iodine, thyroid hormones and pregnancy", June 2012.

Multidisciplinary involving policy makers, stake holders, industry, scientists and health professionals to discuss a national issue.
Year(s) Of Engagement Activity 2012
 
Description Joint ICE/ECE meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Joint ICE/ECE meeting (International and European Congresses of Endocrinology), Florence, "Placental transport of thyroid hormone", May 2012.

Appreciative audience
Year(s) Of Engagement Activity 2012
 
Description Late breaking oral abstract 14th International thyroid Congress, 2010 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Thousands of delegates from around the globe.

Stimulated discussion of those in field.
Year(s) Of Engagement Activity 2010
 
Description Mount Sinai Hospital, Toronto 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Health professionals
Results and Impact Mount Sinai Hospital, Toronto, "Subclinical thyroid dysfunction - should Obstetricians pay attention?" May 2012

discussions of controversial aspects of care.
Year(s) Of Engagement Activity 2012
 
Description Nottingham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Health professionals
Results and Impact Academic Division of Child Health, University of Nottingham, "Thyroid status and perinatal development", January 2012.

Good discussion
Year(s) Of Engagement Activity 2012
 
Description Perinatal Research Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact About 100 clinicians and basic scientists in the area of Obstetrics and Neonatology attended this meeting in West Virginia, USA.

Further invitations to speak at other meetings in North America.
Year(s) Of Engagement Activity 2011
 
Description Poster presentation BTA 2009 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach National
Primary Audience Health professionals
Results and Impact 100 attendees from UK from basic science and clinical backgrounds

Won first prize for poster presentation.
Year(s) Of Engagement Activity 2009
 
Description Presentation in Hong Kong 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Invited to Hong Kong to give a series of lectures which have included our research work on MCT8 in placenta.

None yet
Year(s) Of Engagement Activity 2009
 
Description RCOG Annual Professional Development Conference 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact Royal College of Obstetricians & Gynaecologists Annual Professional Development Conference, London, "Management of thyroid disease in pregnancy - can optimising therapy improve outcome", November 2012.

Discussion on management of controversial areas.
Year(s) Of Engagement Activity 2012
 
Description Traveller's meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact A 15 minute oral presentation was made to both practising and retired consultant Obstetricians and Gynaecologists at a Traveller's meeting in Birmingham.

The talk had highlighted for the first time the issues of thyroid hormone inadequecy in pregnancy upon placental and fetal development to some members of the audience.
Year(s) Of Engagement Activity 2007
 
Description Trustess of Wellbeing of Women 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Presented research to Trustees of Wellbeing of Women Charity.

Further grant funding from Wellbeing of Women.
Year(s) Of Engagement Activity 2009
 
Description Visit of research charity Action Medical Research to Birmingham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact 2 members of staff from AMR

Good feedback to contributors of funds to research charity
Year(s) Of Engagement Activity 2010