Lipotoxicity, the link between obesity and the Metabolic Syndrome: pathogenic mechanisms and therapeutic strategies.

Lead Research Organisation: University of Cambridge
Department Name: Clinical Biochemist

Abstract

Obesity and obesity-associated diabetes are becoming more and more common. These days we see more obese children developing the same type of diabetes that previously was seen exclusively seen in adults. Complications related to obesity and diabetes are presenting more frequently as this prematurely obese population ages. Obese and diabetic individuals are at high risk of dying at an early age, principally from heart attacks. The ideal strategy would be to prevent people becoming obese, but it is clear that obesity prevention, be it by public health measures or drug treatments, is failing. Our final goal is to prevent obese people from becoming diabetic and having heart attacks. To do this we investigate how being obese causes diabetes or heart disease and how to tackle or prevent these diseases in an obese state. We think that the main problem is that obese people fail to store fat in the correct place, which is adipose tissue. When adipose tissue becomes full then fat spills over into other organs such as the liver. When fat accumulates in organs such as muscle or liver it has toxic effects, a process we call lipotoxicity. In this grant application we study how these toxic effects of fat occur, and what can we do to treat it or prevent it. For this we need to use mouse models, to fully understand how the whole body deals with excess fat. The strategies we propose include; a) to make the adipose tissue healthier so it can trap fat better, b) increasing the capability of organs (such as muscle and even adipose tissue itself) to burn fat. While this may not cure obesity it may at least prevent people from dying from it. We hope our research will help to control the coming epidemics of heart attacks, diabetes and strokes caused by obesity.

Technical Summary

The aim of this grant is to understand the metabolic events linking obesity and insulin resistance and to provide scientific support for strategies to treat/prevent these conditions. Our hypothesis is that inappropriate lipid storage in tissues other than adipose is the major underlying factor linking obesity and insulin resistance. The concept that ectopic lipid deposition causes insulin resistance is also known as lipotoxicity. We have developed two main concepts based on the lipotoxicity hypothesis: a) Improving the capacity for lipid storage in adipose will protect against insulin resistance and diabetes. b) In the advent of a failure to store lipid appropriately in adipose tissue then mitochondrial oxidation of lipids will protect against diabetes. This grant will investigate these concepts. The first concept will be addressed by investigating the ability of Prostaglandin F2a in promoting preadipocyte proliferation and therefore enabling increased adipose tissue storage capacity which in turn should prevent the development of insulin resistance. The second concept will be addressed by investigating the role of coactivators PGCs and bone morphogenic protein 8b (BMP8b) in regulating mitochondrial oxidation and preventing lipotoxicity through burning excess lipid. The components of the applications make extensive use of animal models, as well as sophisticated physiological phenotyping tools. This information will be combined with molecular studies using a systems biology approach funded through current FP6 Hepadip and FP7 Etherpath grants to evaluate the global impact of these genetic modifications on energy homeostasis.

Publications


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Barbarroja N (2010) The obese healthy paradox: is inflammation the answer? in The Biochemical journal
Bartolomucci A (2012) The Obese Species: a special issue on obesity and metabolic disorders. Foreword. in Disease models & mechanisms
Carobbio S (2013) Adipogenesis: new insights into brown adipose tissue differentiation. in Journal of molecular endocrinology
 
Title Development of new webb for the TVP lab 
Description tvp.mrl.ims.cam.ac.uk/ 
Type Of Art Creative Writing 
Year Produced 2013 
Impact Much broader reach attracting more visitors 
URL http://www.tvp.mrl.ims.cam.ac.uk/
 
Description EASO Advisory Board Meeting
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Redefinition of obesity on the basis of body composition. BMI considered obsolete.
 
Description Organisation of conferences/Courses
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact It is expected these training schemes have contributed to better care and scientifc developments. Member of the Scientific Organising Committee 1. Cambridge, United Kingdom. 30th June - 2nd July 2015. EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. 2. Boston, USA. 5th - 9th June 2015. ADA Scientific Sessions Insulin Action/Molecular Metabolism. 3. Colorado, USA. 9th - 13th February 2015. Keystone Symposia - Systems Biology of Lipid Metabolism. 4. Madrid, Spain. 7th - 8th November 2014. CNIC Conference "Energy homeostasis and metabolic disease". 5. Madrid, Spain. 7th-8th November 2014. Energy homeostasis and metabolic disease. CNIC. 6. Cambridge, UK. 30th September 2014. 14th Annual Cambridge Immunology Forum Meeting. • Member of the Scientific Organising Committee Keystone meeting on Nuclear receptors. (http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=1235?Tab=travel) Austria (2013) • Member of the Scientific Organising Committee 15th European Congress of Endocrinology 27th April - 1st May 2013. Copenhagen, Denmark (http://www.ece2013.org/committees.aspx) • Director of The European Atherosclerosis Society Advanced Course IV: Murine Genetics and Cardiometabolic Phenotyping 11th - 14th July 2012. Cambridge, United Kingdom (http://www.eas-society.org/advanced-course-iv,-cambridge.aspx • Member of the Organising Scientific Committee of The Royal Society and Academy of Medical Sciences symposium on "Brown adipose tissue: a new human organ?" London (2012) (http://www.physoc.org/me2012) • Member of the Organising Scientific Committee The Obese Species Workshop Sicily, Italy. 21st - 26th October (2011) http://theobesespecies.unipr.it/. • Member of the Organising Scientific Committee for the meeting of the EAS in Hamburg. Germany (2010) • Member of the Organising Scientific Committee of the 49th International Conference on the Bioscience of Lipids. Maastrich (2008)
 
Description Prediction of weight loss and regain following dietary, lifestyle, and pharmacologic intervention.
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Prediction of weight loss and regain following dietary, lifestyle, and pharmacologic intervention. Napolitano A, Miller SR, Murgatroyd PR, Delafont B, Brooke A, Elkhawad M, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ.Clin Pharmacol Ther. 2012 Jun;91(6):1027-34. doi: 10.1038/clpt.2011.333. Epub 2012 Feb 15.
 
Description BBSRC Project Grant (Role of fatty acid chain length in energy balance and adaptive thermogenesis)
Amount £513,407 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 03/2009 
End 02/2012
 
Description Cambridge-NUHS Seed Fund
Amount $35,000 (SGD)
Funding ID Study of FIT FAT 
Organisation National University Health System (NUHS) 
Sector Public
Country Singapore, Republic of
Start  
 
Description FP7 - EU grant. BETA BAT. 2011-2015.
Amount £600,000 (GBP)
Organisation Community Research and Development Information Service (CORDIS) 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 03/2011 
End 02/2015
 
Description FP7 EU grant ETHERPATH
Amount £653,022 (GBP)
Organisation Community Research and Development Information Service (CORDIS) 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 03/2009 
End 02/2012
 
Description MRC MDU Programme Grant
Amount £2,000,000 (GBP)
Funding ID MRC MDU Programme Grant 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2013 
End 03/2018
 
Title Development of methodology for microarray and lipidomic analysis 
Description We have contributed to develop methods for lipid analysis 
Type Of Material Technology assay or reagent 
Year Produced 2007 
Provided To Others? Yes  
Impact 1) Oresic M, H?nninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers.Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23PMID: 18951641 2)Tang J, Tan CY, Oresic M, Vidal-Puig A. Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35. [Epub ahead of print] PMID: 19341506 3) Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M. Informatics and computational strategies for the study of lipids.Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. 4).Oresic M, Vidal-Puig A, H?nninen V.Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. 
URL http://europepmc.org/abstract/MED/18951641
 
Title Differentiation of ES cells 
Description Protocols do differentiation of Human PSC to brown, white and macrophage phenotype 
Type Of Material Cell line 
Provided To Others? No  
Impact Competitiveness in our research and funding acquisition e.g. ERC grant 
 
Title Tools for data quatification 
Description LEM-PCR: a method for determining relative transcript isoform proportions using real-time PCR without a standard curve.Virtue S, Dale M, Sethi JK, Vidal-Puig A. Genome. 2010 Aug;53(8):637-42. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2010 
Provided To Others? Yes  
Impact Improved accuracy of data analysis 
 
Title b) Design a unique in house system for energy balance measurement. 
Description This is a new cageingsystem for metabolicphenotyping for simultaneous assessment of food inatke, energy expnditure, activity, water consumption. The equipment incorporates novel features such as having food delivery system hook to the cover of the cage. Also this is system is adapted to the cages where are normally hold which prevents measurement artifacts derived from changes in the cages when performing metabolic measurements. The new developed system to assess energy balance is a refinement because we can measure more accurately in each experiment. The addition of a 24h camera system with Visual Sonics software enables us to have secure systems to observe without disturbing measurements. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact Reduction and refinement of experiments using murine models 
 
Title metabolic Cages 
Description In collaboration with Ideas Studio, we have designed new metabolic cages (SMS cages) that monitor movement, food preference and consumption, water consumption. This caging system is set for calorimetry and has its own lighting and a camera attached so the animals can be checked without having to enter the room. This equipment represents a refinement compared to the previously used CLAM system from Columbus. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact This caging system is set for calorimetry and has its own lighting and a camera attached so the animals can be checked without having to enter the room. This equipment represents a refinement compared to the previously used CLAM system from Columbus. 
 
Title Technology for lipidomic data analysis 
Description Development of tools for lipid analysis and integration with gene expressison analysis using multivariant analysis 
Type Of Material Data analysis technique 
Year Produced 2014 
Provided To Others? Yes  
Impact Fundamental for papers including lipidomic analysis which is central to our programme 
 
Title Tissue bank from mice undergoing physiological challenges and specific genetic modifications 
Description This tissues and their RNA are being used for quick validation of metabolic relevance of genes identified by genomic approaches. This resourcedecreases the need of experimental groups of animals 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact identification of interesting candidate genes for metabolic disease prioritising murine work 1. Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2015 Dec 17;5:18366. doi: 10.1038/srep18366. 2. Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004. Epub 2015 Nov 25. 3. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author 5. Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 6. Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. 7. Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM. Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation. Diabetologia. 2015 Jul 23. 
 
Description Bioinformatics 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Data generation in metabolic studies
Collaborator Contribution Modelling/Bioinformatic analysis
Impact Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi JK, Dopazo J, Orešic M, Ricote M, Vidal-Puig A.Diabetes. 2011 Mar;60(3):797-809. doi: 10.2337/db10-0705. Epub 2011 Jan 24.MID: 21266330 Free PMC Article Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A. Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis. Mol Metab. 2015 Nov 11;5(1):19-33. doi: 10.1016/j.molmet.2015.10.005. eCollection 2016 Jan. PMID: 26844204 Free PMC Article Sebastian-Leon P, Vidal E, Minguez P, Conesa A, Tarazona S, Amadoz A, Armero C, Salavert F, Vidal-Puig A, Montaner D, Dopazo J.Understanding disease mechanisms with models of signaling pathway activities. BMC Syst Biol. 2014 Oct 25;8:121. doi: 10.1186/s12918-014-0121-3.PMID: 25344409 Free PMC Article
Start Year 2011
 
Description Bioinformatics 
Organisation Regional Government of Valencia
Department Príncipe Felipe Research Centre (CIPF)
Country Spain, Kingdom of 
Sector Charity/Non Profit 
PI Contribution Data generation in metabolic studies
Collaborator Contribution Modelling/Bioinformatic analysis
Impact Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi JK, Dopazo J, Orešic M, Ricote M, Vidal-Puig A.Diabetes. 2011 Mar;60(3):797-809. doi: 10.2337/db10-0705. Epub 2011 Jan 24.MID: 21266330 Free PMC Article Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A. Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis. Mol Metab. 2015 Nov 11;5(1):19-33. doi: 10.1016/j.molmet.2015.10.005. eCollection 2016 Jan. PMID: 26844204 Free PMC Article Sebastian-Leon P, Vidal E, Minguez P, Conesa A, Tarazona S, Amadoz A, Armero C, Salavert F, Vidal-Puig A, Montaner D, Dopazo J.Understanding disease mechanisms with models of signaling pathway activities. BMC Syst Biol. 2014 Oct 25;8:121. doi: 10.1186/s12918-014-0121-3.PMID: 25344409 Free PMC Article
Start Year 2011
 
Description Brown fat 
Organisation The Wenner-Gren Institute
Department Phsyiology
Country Sweden, Kingdom of 
Sector Academic/University 
PI Contribution We have developed a new area of research focused on BAT
Collaborator Contribution Knowledge and technology
Impact Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 61(12):3139-47 (2012).Virtue S, F.H., Christian M, Tan CY, Masoodi M, Dale M, et al (10 authors) Vidal-Puig A. Diabetes in press (2012), Virtue, S., M. Christian, C. Tan, M. Masoodi, M. Dale, ( 10 authors) A. Vidal-Puig, A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes (in press) 2012. Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85.
Start Year 2006
 
Description Clinical Research 
Organisation University of Girona
Department Faculty of Medicine
Country Spain, Kingdom of 
Sector Academic/University 
PI Contribution Provision of candidate genes for subsequent validation in human studies
Collaborator Contribution Access of adipose tissue bank
Impact Lagathu, C., C. Christodoulides, C.Y. Tan, S. Virtue, M. Laudes, M. (7 authors) A. Vidal-Puig, Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond), 2010. 34(12): p. 1695-705. Rodriguez-Cuenca, S., S. Carobbio, V.R. Velagapudi, N. Barbarroja, J.M. Moreno-Navarrete,( 5 authors) A. Vidal-Puig, Peroxisome proliferator-activated receptor gamma-dependent regulation of lipolytic nodes and metabolic flexibility. Mol Cell Biol, 2012. 32(8): p. 1555-65 Kilpelainen, T.O., M.C. Zillikens, A. Stancakova, F.M. Finucane, J.S. Ried, C. Langenberg, (65 authors) A. Vidal-Puig, (40 authors) R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 2011. 43(8): p. 753-60. Moreno-Navarrete JM, Escoté X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Frühbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal-Puig A, Fernández-Real JM. A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. Diabetologia 2013 Nov;56(11):2524-37 Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] Napolitano A, Miller SR, Murgatroyd PR, Delafont B, Brooke A, Elkhawad M, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ. Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention. Clin Pharmacol Ther. 2012 Feb 15 Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. PPAR? DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY. Moll Cell Biol. 2012 Feb 6. Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM.Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation. Diabetologia. 2015 Oct;58(10):2424-34. doi: 10.1007/s00125-015-3692-7. Epub 2015 Jul 23.PMID: 26201685 Ortega FJ, Serrano M, Rodriguez-Cuenca S, Moreno-Navarrete JM, Gómez-Serrano M, Sabater M, Rodriguez-Hermosa JI, Xifra G, Ricart W, Peral B, Vidal-Puig A, Fernández-Real JM. Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPAR? gene expression. J Mol Med (Berl). 2015 Jan;93(1):83-92. doi: 10.1007/s00109-014-1207-5. Epub 2014 Sep 25. PMID: 25249007 Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115.
Start Year 2011
 
Description Flies as a disease model to study metabolic disease 
Organisation Helmholtz Association of German Research Centres
Department German Cancer Research Center (DKFZ)
Country Germany, Federal Republic of 
Sector Public 
PI Contribution provide hypothesis for validation in flies and also perform experiments in mammalian systems with insights coming from flies.
Collaborator Contribution generation of genetically modified flies mimicking mouse or cell genetic modification.
Impact Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2015
 
Description LPGD2S KO MOUSe 
Organisation Osaka University
Country Japan 
Sector Academic/University 
PI Contribution Phenotyping of mouse models
Collaborator Contribution provided animal models for MRC funded project.
Impact Papers still under submission expected to be published during 2010
Start Year 2007
 
Description Lipidomic analysis in the context of lipotoxicity 
Organisation Technical Research Centre of Finland (VTT)
Department QBIX Group
Country Finland, Republic of 
Sector Private 
PI Contribution We have provided biological samples for lipidomic analysis and th eintellectual background to justify this programme of research
Collaborator Contribution The lab of Prof Matej Oresic has performed lipidomic analysis in murine tissues from our genetically modified models. Our models have provided biological material for analytical platform development. Funding forthis experiments has been provided through collaborative FP6 Hepadip and FP7 Etherpath grants,
Impact Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A.Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6. PMID: 23919961 Free PMC Article Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-PuigLipocalin prostaglandin D synthase and PPAR?2 coordinate to regulate carbohydrate and lipid metabolism in vivo.A.PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5. PMID: 22792179 Free PMC Article1. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi J, Dopazo J, Oresic M, Ricote M, Vidal-Puig A. Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice. Diabetes Jan 24, 2011. Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešic M. Association of lipidome remodelling in the adipocyte membrane with acquired obesity in humans. PLoS Biol June 7, 2011. 1.Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. 3. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A.Nat Med. 2010 Sep;16(9):1001-8. Epub 2010 Aug 29. PMID: 20802499 [PubMed - indexed for MEDLINE]Related citations Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešic M, Sethi JK, Vidal-Puig A.4.Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond). 2010 Jun 1. PMID: 20514047 [PubMed - as supplied by publisher] 5.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig .Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 [PubMed - in process]Free PMC ArticleFree text Tang J, Tan CY, Oresic M, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 [PubMed - indexed for MEDLINE] . Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.8.Informatics and computational strategies for the study of lipids Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. PMID: 18213405 [PubMed - indexed for MEDLINE] Related citations 9.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 10.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M. BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 11.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. PLoS Biol. 2006 Nov;4(11):e369. PMID: 17090215 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text Related citations 12.Metabolomic approaches to phenotype characterization and applications to complex diseases. Oresic M, Vidal-Puig A, Hänninen V. Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 [PubMed - indexed for MEDLINE] Related citations 13.Pathways to the analysis of microarray data. Curtis RK, Oresic M, Vidal-Puig A. Trends Biotechnol. 2005 Aug;23(8):429-35. Review. PMID: 15950303 [PubMed - indexed for MEDLINE] Related citations 14.The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. 15.Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. Diabetes. 2005 Jun;54(6):1706-16. PMID: 15919792 [PubMed - indexed for MEDLINE]Free Article Related citations
 
Description Lipidomic technology 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Group
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution provided intellectual framework, experimental design and biological samples.
Collaborator Contribution Providing lipidomic analysis from biological samples.
Impact 1.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 2.Tang J, Tan CY, Oresic M, Vidal-Puig A.Integrating post-genomic approaches as a strategy to advance our understanding of health and disease.Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 3.Oresic M, Hänninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 4.Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.Informatics and computational strategies for the study of lipids. Mol Biosyst. 2008 Feb;4(2):121-7. PMID: 18213405 5.Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 6.Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis.BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 7.Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.PLoS Biol. 2006 Nov;4(11):e369.PMID: 17090215 8.Oresic M, Vidal-Puig A, Hänninen V. Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 15. Virtue S, F.H., Christian M, Tan CY, Masoodi M, Dale M, et al (10 authors) Vidal-Puig A. Diabetes in press (2012), A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes, (2012.) Virtue, S., M. Christian, C. Tan, M. Masoodi, M. Dale, C. ( 10 authors) A. Vidal-Puig, A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 2012. Griffin, J.L. and A. Vidal-Puig, Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding? Physiol Genomics, 2008. 34(1): p. 1-5. Pietilainen, K.H., T. Rog, T. Seppanen-Laakso, S. Virtue, P. Gopalacharyulu, J.(16 authors), A. Vidal-Puig, and M. Oresic, Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol, 2011. 9(6): p. e1000623. 19. Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. 20. Kilpelainen, T.O., M.C. Zillikens, A. Stancakova, F.M. Finucane, J.S. Ried, C. Langenberg, (65 authors) A. Vidal-Puig, (40 authors) R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 2011. 43(8): p. 753-60. 21. Medina-Gomez, G., L. Yetukuri, V. Velagapudi, M. Campbell, M. Blount,et al (3 authors), A. Vidal-Puig, Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech, 2009. 2(11-12): p. 582-92. 22. Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 61(12):3139-47 (2012). 4. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] 12. Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-Puig A. Lipocalin Prostaglandin D Synthase and PPAR?2 Coordinate to Regulate Carbohydrate and Lipid Metabolism In Vivo. PLoS One 7(7):e39512. (2012) Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. PPAR? DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY. Moll Cell Biol. 2012 Feb 6.
Start Year 2006
 
Description Lipidomic technology 
Organisation Technical Research Centre of Finland (VTT)
Department Matej Oresic VTT
Country Finland, Republic of 
Sector Academic/University 
PI Contribution provided intellectual framework, experimental design and biological samples.
Collaborator Contribution Providing lipidomic analysis from biological samples.
Impact 1.Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech. 2009 Nov-Dec;2(11-12):582-92. Epub 2009 Oct 19. PMID: 19841237 2.Tang J, Tan CY, Oresic M, Vidal-Puig A.Integrating post-genomic approaches as a strategy to advance our understanding of health and disease.Genome Med. 2009 Mar 30;1(3):35.PMID: 19341506 3.Oresic M, Hänninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23. PMID: 18951641 4.Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M.Informatics and computational strategies for the study of lipids. Mol Biosyst. 2008 Feb;4(2):121-7. PMID: 18213405 5.Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A.PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.PLoS Genet. 2007 Apr 27;3(4):e64. PMID: 17465682 6.Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M.Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis.BMC Syst Biol. 2007 Feb 15;1:12. PMID: 17408502 7.Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.PLoS Biol. 2006 Nov;4(11):e369.PMID: 17090215 8.Oresic M, Vidal-Puig A, Hänninen V. Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. PMID: 16824031 15. Virtue S, F.H., Christian M, Tan CY, Masoodi M, Dale M, et al (10 authors) Vidal-Puig A. Diabetes in press (2012), A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes, (2012.) Virtue, S., M. Christian, C. Tan, M. Masoodi, M. Dale, C. ( 10 authors) A. Vidal-Puig, A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 2012. Griffin, J.L. and A. Vidal-Puig, Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding? Physiol Genomics, 2008. 34(1): p. 1-5. Pietilainen, K.H., T. Rog, T. Seppanen-Laakso, S. Virtue, P. Gopalacharyulu, J.(16 authors), A. Vidal-Puig, and M. Oresic, Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol, 2011. 9(6): p. e1000623. 19. Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. 20. Kilpelainen, T.O., M.C. Zillikens, A. Stancakova, F.M. Finucane, J.S. Ried, C. Langenberg, (65 authors) A. Vidal-Puig, (40 authors) R.J. Loos, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 2011. 43(8): p. 753-60. 21. Medina-Gomez, G., L. Yetukuri, V. Velagapudi, M. Campbell, M. Blount,et al (3 authors), A. Vidal-Puig, Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech, 2009. 2(11-12): p. 582-92. 22. Vivas, Y., C. Martinez-Garcia, A. Izquierdo, F. Garcia-Garcia, S. Callejas, (4 authors), A. Vidal-Puig, and G. Medina-Gomez, Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 2012. 4: p. 86. Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation. Diabetes 61(12):3139-47 (2012). 4. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] 12. Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešic M, Urade Y, Griffin JL, Vidal-Puig A. Lipocalin Prostaglandin D Synthase and PPAR?2 Coordinate to Regulate Carbohydrate and Lipid Metabolism In Vivo. PLoS One 7(7):e39512. (2012) Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. PPAR? DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY. Moll Cell Biol. 2012 Feb 6.
Start Year 2006
 
Description Mechanisms of CNS control of Energy Balance 
Organisation University of Santiago de Compostela
Country Spain, Kingdom of 
Sector Academic/University 
PI Contribution We provide the generation and metabolic charaterisation of murine models.
Collaborator Contribution Dr Miguel Lopez was a former fellow in my lab and now has established his own lab in Santiago. He is an expert in Neuroanatomy and as such he provides his expertise to the CNS characterisation of our genetically modified mouse mopdels
Impact Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vázquez MJ, Morgan D, Csikasz RI, Gallego R, Rodriguez-Cuenca S, Dale M, Virtue S, Villarroya F, Cannon B, Rahmouni K, López M, Vidal-Puig A. BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions. Cell. 2012 May 11;149(4):871-85. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes 2013 Aug 6. [Epub ahead of print] Fernø J, Varela L, Skrede S, Vázquez MJ, Nogueiras R, Diéguez C, Vidal-Puig A, Steen VM, López M. Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation. PLoS One June 13, 2011. 2. Skrede S, Fernø J, Vázquez MJ, Fjær S, Pavlin T, Lunder N, Vidal-Puig A, Diéguez C, Berge RK, López M, Steen VM. Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. Int J Neuropsychopharmacol. August, 2011. 3.Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. 4.López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A. Nat Med. 2010 Sep;16(9):1001-8. Epub 2010 Aug 29. PMID: 20802499 [PubMed - indexed for MEDLINE] Related citations 5.Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C, López M. FASEB J. 2010 Aug;24(8):2670-9. Epub 2010 Mar 24. PMID: 20335227 [PubMed - indexed for MEDLINE] Related citations 6.AMPK: a metabolic gauge regulating whole-body energy homeostasis. Lage R, Diéguez C, Vidal-Puig A, López M. Trends Mol Med. 2008 Dec;14(12):539-49. Epub 2008 Nov 1. Review. PMID: 18977694 [PubMed - indexed for MEDLINE] Related citations 7.Brain lipogenesis and regulation of energy metabolism. López M, Vidal-Puig A. Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):483-90. Review. PMID: 18542011 [PubMed - indexed for MEDLINE] Related citations 8.Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion. 9.Vázquez MJ, González CR, Varela L, Lage R, Tovar S, Sangiao-Alvarellos S, Williams LM, Vidal-Puig A, Nogueiras R, López M, Diéguez C. Endocrinology. 2008 Sep;149(9):4534-43. Epub 2008 May 22. PMID: 18499762 [PubMed - indexed for MEDLINE]Free Article Related citations 10.Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. 11.López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A. Cell Metab. 2008 May;7(5):389-99. PMID: 18460330 [PubMed - indexed for MEDLINE] Related citations
Start Year 2008
 
Description Mitochondria metabolism 
Organisation Mario Negri Institute for Pharmacological Research (Istituto Di Ricerche Farmacologiche Mario Negri)
Department Department of Pharmacology
Country Italy, Italian Republic 
Sector Academic/University 
PI Contribution Exchange of murine models and reagents as well as intellectual exchange.
Collaborator Contribution Current collaboration on the characterisation of the effects of PGC1b in gut and liver,
Impact D'Errico I, Salvatore L, Murzilli S, Lo Sasso G, Latorre D, Martelli N, Egorova AV, Polishuck R, Madeyski-Bengtson K, Lelliott C, Vidal-Puig AJ, Seibel P, Villani G, Moschetta A. Peroxisome proliferator-activated receptor-{gamma} coactivator 1-{alpha} (PGC1{alpha}) is a metabolic regulator of intestinal epithelial cell fate. Proc Natl Acad Sci USA April 5, 2011
Start Year 2010
 
Description Molecular mechanisms of mitochondrial biogenesis 
Organisation AstraZeneca
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Private 
PI Contribution Provided biological samples for platform development
Collaborator Contribution Providing animal models generated by AZaccess to lipidomic platforms
Impact Integration in FP7 Etherpath grant
Start Year 2008
 
Description Molecular mechanisms of mitochondrial biogenesis 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Provided biological samples for platform development
Collaborator Contribution Providing animal models generated by AZaccess to lipidomic platforms
Impact Integration in FP7 Etherpath grant
Start Year 2008
 
Description Molecular mechanisms of mitochondrial biogenesis 
Organisation Zora Biosciences Oy
Country Finland, Republic of 
Sector Private 
PI Contribution Provided biological samples for platform development
Collaborator Contribution Providing animal models generated by AZaccess to lipidomic platforms
Impact Integration in FP7 Etherpath grant
Start Year 2008
 
Description Thermogenesis 
Organisation Chiba University
Country Japan 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2010
 
Description Thermogenesis 
Organisation Helmholtz Association of German Research Centres
Department German Cancer Research Center (DKFZ)
Country Germany, Federal Republic of 
Sector Public 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2010
 
Description Thermogenesis 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Charity/Non Profit 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2010
 
Description Thermogenesis 
Organisation Toho University
Country Japan 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2010
 
Description Thermogenesis 
Organisation University of Graz
Department Institute of Molecular Biosciences
Country Austria, Republic of 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2010
 
Description Thermogenesis 
Organisation University of Minnesota
Department Department of Integrative Biology and Physiology
Country United States of America 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2010
 
Description Thermogenesis 
Organisation University of Newcastle
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2010
 
Description Thermogenesis 
Organisation University of Santiago de Compostela
Department Physiology
Country Spain, Kingdom of 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2010
 
Description Thermogenesis 
Organisation University of Stockholm
Department Werner Institute
Country Sweden, Kingdom of 
Sector Academic/University 
PI Contribution Murine generation and Phenotyping
Collaborator Contribution Specific Thermogenic studies covering CNS, BAT and electrophysiology
Impact Whittle, A.J., S. Carobbio, L. Martins, M. Slawik, E. Hondares, (11 authors),A. Vidal-Puig, BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 2012. 149(4): p. 871-85. Lopez, M., R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, (17 authors), A. Vidal-Puig, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 2008. 7(5): p. 389-99. Lopez, M., L. Varela, M.J. Vazquez, S. Rodriguez-Cuenca, C.R. Gonzalez,(16 authors) and A. Vidal-Puig, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 2010. 16(9): p. 1001-8. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601.
Start Year 2010
 
Description macrophage 
Organisation Spanish Ministry of Health and Consumer Affairs
Department National Center for Cardiovascular Research (CNIC)
Country Spain, Kingdom of 
Sector Public 
PI Contribution Generation of original mouse models and characterisation
Collaborator Contribution Generation of murine models targeting specific genetic modification to macrophages
Impact Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. Virtue S, Masoodi M, de Weijer BA, van Eijk M, Mok CY, Eiden M, Dale M, Pirraco A, Serlie MJ, Griffin JL, Vidal-Puig A. Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans. Int J Obes (Lond). 2015 Mar 24. doi: 10.1038/ijo.2015.34
Start Year 2011
 
Description macrophage 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Charity/Non Profit 
PI Contribution Generation of original mouse models and characterisation
Collaborator Contribution Generation of murine models targeting specific genetic modification to macrophages
Impact Prieur, X., C.Y. Mok, V.R. Velagapudi, V. Nunez, L. Fuentes, D. (9 authors), A. Vidal-Puig, Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60(3): p. 797-809. Virtue S, Masoodi M, de Weijer BA, van Eijk M, Mok CY, Eiden M, Dale M, Pirraco A, Serlie MJ, Griffin JL, Vidal-Puig A. Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans. Int J Obes (Lond). 2015 Mar 24. doi: 10.1038/ijo.2015.34
Start Year 2011
 
Description Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact . Colorado, USA. 22nd - 27th January 2017. Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology.
Year(s) Of Engagement Activity 2016
 
Description Tokyo, Japan. 18th July 2013. Special lecture at Toho University Medical Center 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Toni Vidal-Puig visits the lab of Professor Hideaki Bujo at Toho University in Japan as part of their collaborative research programme on brown fat differentiation.
Year(s) Of Engagement Activity 2013
URL http://tvp.mrl.ims.cam.ac.uk/events/
 
Description Vienna, Austria. 15th-19th October 2016. UEG Week. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 2. Vienna, Austria. 15th-19th October 2016. UEG Week. Main meeting on gastroenterology in Europe.
Year(s) Of Engagement Activity 2016
 
Description . Cambridge, UK. 11th April 2016. British Heart Foundation Cardiovascular Research Excellence Annual Event. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact 4. Cambridge, UK. 11th April 2016. British Heart Foundation Cardiovascular Research Excellence Annual Event.
Year(s) Of Engagement Activity 2016
 
Description . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London.
Year(s) Of Engagement Activity 2016
 
Description 3. Tsukuba, Japan. 17th-19th September 2016. Tsukuba Global Science Week. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Tsukuba, Japan. 17th-19th September 2016. Tsukuba Global Science Week.
Year(s) Of Engagement Activity 2016
 
Description 30th September 14th Annual Cambridge Immunology Forum Meeting Cambridge, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 14th Annual Cambridge Immunology Forum Meeting
Organisers: Marc Veldhoen, Arthur Kaser, Toni Vidal-Puig, Brian Ferguson

Increased knowledge and projection of the lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/upcoming-conferences-organised-by-prof-vidal-puig/
 
Description ADA 2016. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact New Orleans, USA. 10th - 14th June 2016. American Diabetes Association's Scientific Session's 76th Scientific Sessions.
Year(s) Of Engagement Activity 2016
 
Description Advisory Board Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact EASO Scientific Advisory Board Meeting
18th - 19th March 2013, Brussels


redefinitionn of obesity on the baseis of body composition. BMI considered obsolete.
Year(s) Of Engagement Activity 2013
 
Description Award Lecture in Boston, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Health professionals
Results and Impact 22nd Pat Usher Memorial Award Lecture, Harvard Medical School, Boston, USA. 18th January 2013.

-
Year(s) Of Engagement Activity 2013
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Fighting fat with fat
Obesity is one of the most important biomedical problems in our society and also one of the most frustrating to tackle. For this reason, the recent identification of functional brown fat in adult humans has made the obesity research community very excited. Read more here.

Sanger Institute Blog by Dr Stefania Carobbio

Projection of our lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description Blog BAT 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description Cherry Hinton Lions Under 10s Blue Football Club sponsored by IMS/TVP lab 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact This is an action to promote fitness in children as a strategy to prevent orreverse obesity

Children know what is the IMS and that obesity and diabetes can be prevented by exercise.
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Communicating related to impact of our research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact News about our papers were disseminated through BBC radio, and TV ( BBC look East). Also through multiple webs and also reached internationally through links with European commision.

These media are supposed to reach out to the general public.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
 
Description Comparison between Angloxason and Continental research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/parliamentarians
Results and Impact 200 people including govermental, helath policy makers, bankers, benefactors from the valencia region in Spain, attended my presentation. This was a very controversial presenation that was well received.

Higly involved in restrusturing the scientific organisation in Spain following the UK and USA model. This may benefit UK from the point of view of exerting influence and future partnerships ( e.g Santader bank activities in UK and Spain.)
Year(s) Of Engagement Activity 2011
 
Description Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Edmonton, Canada. 2nd May 2016. Distinguished Speaker Lecture, University of Alberta. !50 approx. students and post docts attended lecture.
Year(s) Of Engagement Activity 2016
 
Description Contribution to the Biochemist 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact The metabolic syndrome - where do we go from here?
Chong Yew Tan and Antonio Vidal-Puig. The Biochemist. 2009.


We were contacted by the Director of BBSRC Douglas Kell and participated in hib blog.
Year(s) Of Engagement Activity 2009
 
Description Daily mail 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Why your love handles may be GOOD for you: The latest finding might ease your fears about your chubby bits.
(http://www.dailymail.co.uk/health/article-1385299/Love-handles-GOOD-The-latest-findings-ease-fears-chubby-bits.html#ixzz1cYnUfnDd)


I was subsequently contacted by Weight watchers to pariticipate in their magazine.
Year(s) Of Engagement Activity 2011
URL http://www.dailymail.co.uk/health/article-1385299/Love-handles-GOOD-The-latest-findings-ease-fears-c...
 
Description Dr Sam Virtue presents to the York Branch of Diabetes UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact A talk to the York Branch of Diabetes UK. Diabetes UK is the leading independent charity raising money for the study of diabetes in the UK. Over twenty people who are involved in fundraising for Diabetes UK attended the tak which focussed on the causes of type II diabetes and potential new treatments based on the work of the TVP laboratory in the field of brown adipose tissue.


Education of Diabetes UK Fund Raisers.
Year(s) Of Engagement Activity 2012
 
Description Europe press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact This was an interview for Europe press news agency which has a huge diseminattion capacity. Some examples below.

http://www.europapress.es/chance/noticias.aspx?buscar=Antonio%2BVidal%2BPuig

http://www.europapress.es/chance/elbuenvivir/noticia-10-obesos-son-saludables-20111128124545.html

http://www.europapress.es/chance/noticias.aspx?buscar=Cambridge

http://www.enfermeriapalencia.com/modules.php?name=Noticias_enfermeras

Highewr visibility. Partients have contacted me through email with personal cases that have I have replayed so far but that if they continue to increase i may need to organise better through my web page. I am considering if i get resources to maintain in to include a page in my web for public questions and disemination.
Year(s) Of Engagement Activity 2011
URL http://www.europapress.es/chance/noticias.aspx?buscar=Antonio%2BVidal%2BPuig
 
Description Heidelberg, Germany. 12th May 2016. Seminar at German Cancer Research Center (DKFZ) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Heidelberg, Germany. 12th May 2016. Seminar at German Cancer Research Center (DKFZ)
Year(s) Of Engagement Activity 2016
 
Description Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology
Year(s) Of Engagement Activity 2016
 
Description Maranon Lecture Award 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Maranon Lecture Award de la Sociedad Espanola de Endocrinologia y Nutricion. Granada, Spain. 15th-17th May 2013.

-
Year(s) Of Engagement Activity 2013
 
Description Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact TVP Lab members give presentations and posters at 1st ICAN conference series in Cardiometabolic Disease

Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. Vanessa Pellegrinelli was selected to give a presentation, and Camilla Ingvorsen, Guillaume Bidault, and Vivian Peirce were selected to present posters. Vivian Peirce was a joint-winner of Young Investigator poster award.



Projection of our lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Mente y cerebro 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact 2009
Article on obesity and body-mass regulation in Mente y cerebro, the Spanish-language edition of the popular magazine Scientific American (http://www.investigacionyciencia.es/03063870000583/Claves_para_entender_la_pandemia_de_obesidad.htm)


This is a magazine with a big audience amongs studnets interested in biology
Year(s) Of Engagement Activity 2009
 
Description PhD student Graduate School of Netaboism in Denmark 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact 40 PhD students attended and through a 3 day meeting many interactions happened.

Attracting very smart PhD to do post doct in UK
Year(s) Of Engagement Activity 2009
 
Description Prof Toni Vidal-Puig special lecture at CICbioGUNE 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact http://www.youtube.com/watch?v=KujRzzNGSVA
The link between obesity and type 2 diabetes is clear on an epidemiological level, however the mechanism linking these two common disorders is not well defined. One hypothesis linking obesity to type 2 diabetes is the adipose tissue expandability hypothesis. The adipose tissue expandability hypothesis states that a failure in the capacity for adipose tissue expansion, rather than obesity per se is the key factor linking positive energy balance and type 2 diabetes. All individuals possess a maximum capacity for adipose expansion which is determined by both genetic and environmental factors. Once the adipose tissue expansion limit is reached, adipose tissue ceases to store energy efficiently and lipids begin to accumulate in other tissues. Ectopic lipid accumulation in non-adipocyte cells causes lipotoxic insults including insulin resistance, apoptosis and inflammation.



This article discusses the links between adipokines, inflammation, adipose tissue expandability and lipotoxicity. Finally, we will discuss how considering the concept of allostasis may enable a better understanding of how diabetes develops and allow the rational design of new anti diabetic treatments



Postdocs applying to the TVP lab and collaborations
Year(s) Of Engagement Activity 2012
URL http://www.youtube.com/watch?v=KujRzzNGSVA
 
Description Prof Vidal-Puig. radio Interview EITB Basque Country 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact http://www.eitb.com/es/audios/detalle/841034/audio-obesos-saludables-anillamiento-aves-nuevas-tecnologias/

Prof. Vidal-Puig discussed for the EITB radio (Basque country, Spain) the impact of the environmental factors contributing to the obesity pandemic in the last half century; the concepts of adipose tissue expandability and the paradox of the "healthy obese" as well as the possibility of developing new strategies aimed to increase energy expenditure to fight against obesity and associated metabolic diseases.
Year(s) Of Engagement Activity 2012
 
Description Radio9 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Radio Magazin (Radio 9) 30 min interview about research and personal profile of a scientist

Bringing closer to the public that a scientist can be a normal human being (hopefully).
Year(s) Of Engagement Activity 2011
 
Description Science Interviews:The Naked Scientists: Science Radio & Science Podcasts 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact Andrew Whittle interview on radio
http://www.thenakedscientists.com/HTML/content/interviews/interview/2096/

Disemination of our research to lay public
Year(s) Of Engagement Activity 2012
URL http://www.thenakedscientists.com/HTML/content/interviews/interview/2096/
 
Description Training Course EAS 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The European Atherosclerosis Society Advanced Course IV: Murine Genetics and Cardiometabolic Phenotyping

Cambridge, United Kingdom

Presenting: Prof Toni Vidal-Puig, Dr Sam Virtue

Organisers: Antonio Vidal-Puig, Barry Rosen, Sam Virtue, Peter Voshol, Roger Foo, Jules Griffin, Paul Flynn

We organised the European Atherosclerosis Society advanced course in murine genetics and cardiometabolic phenotyping

http://tvp.mrl.ims.cam.ac.uk/eas-advanced-course-iv-murine-genetics-and-cardiometabolic-phenotyping/
11th - 14th July 2012

We have obtained feed back from the meeting which is now included in the web of the EAS and also our own web.Following the EAS Advanced Course IV: Murine genetics and cardiometabolic phenotyping in Cambridge this July, we are very pleased that the course was deemed to be a success. 97% rated the educational value of the Course to be high and 98% rated the course to be applicable to their own research. Further feeback can be found here.
http://tvp.mrl.ims.cam.ac.uk/events/
Year(s) Of Engagement Activity 2012
 
Description XL Semanal Interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact This magazine reaches 2 milllion people every weekend. Very important and influencial people use it and it has high reputation.
(http://xlsemanal.finanzas.com/web/articulo.php?id=71018&id_edicion=6527)

Since then I have been approached by

a) Radio 9

b) Press
http://www.elpais.com/articulo/sociedad/interruptor/adelgazamiento/elpepisoc/20110610elpepisoc_1/Tes
Year(s) Of Engagement Activity 2011