Specification of brainstem serotonergic neurons: model for the molecular basis of temporal switching of progenitor fate

Lead Research Organisation: Medical Research Council
Department Name: UNLISTED

Abstract

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Description Cited in Annual Review of Pathology Mechanisms of Disease
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical reviews
Impact Discusses the role of developmental mechanisms in sudden infant death syndrome.
 
Description The Simons Foundation
Amount £161,791 (GBP)
Organisation Simons Foundation 
Sector Charity/Non Profit
Country United States of America
Start 02/2012 
End 01/2014
 
Title Plasmid reagents 
Description Dominant negative constructs that interfere with specific transcription factors 
Type Of Material Technology assay or reagent 
Year Produced 2008 
Provided To Others? Yes  
Impact Used in subsequent research studies, e.g Ribes et al Genes and Development 2010. 
 
Description Foxa2 regulates the switch from visceral motor to serotonergic neurogenesis 
Organisation Biomedical Research Foundation Academy of Athens
Department Developmental Biology
Country Greece, Hellenic Republic 
Sector Academic/University 
PI Contribution My research assistant and I undertook all the experiments, I analysed the data and wrote the manuscript with the Group Leader, Dr J. Briscoe
Collaborator Contribution I initiated the collaboration. Used transgenic mice and plasmid constructs from the collaborating lab. Collaborating lab bred the transgenic mouse lineProvision of plasmid reagents, transgenic mouse lineProvision of reagents including transgenic mouse line
Impact Original article in the journal 'Nature Neuroscience' (see Publications). Collaboration expanded the range of model organisms used in the study.
Start Year 2006
 
Description Foxa2 regulates the switch from visceral motor to serotonergic neurogenesis 
Organisation College of Sciences
Department Department of Biology
Country United States of America 
Sector Academic/University 
PI Contribution My research assistant and I undertook all the experiments, I analysed the data and wrote the manuscript with the Group Leader, Dr J. Briscoe
Collaborator Contribution I initiated the collaboration. Used transgenic mice and plasmid constructs from the collaborating lab. Collaborating lab bred the transgenic mouse lineProvision of plasmid reagents, transgenic mouse lineProvision of reagents including transgenic mouse line
Impact Original article in the journal 'Nature Neuroscience' (see Publications). Collaboration expanded the range of model organisms used in the study.
Start Year 2006
 
Description Foxa2 regulates the switch from visceral motor to serotonergic neurogenesis 
Organisation Medical Research Council (MRC)
Department MRC National Institute for Medical Research (NIMR)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution My research assistant and I undertook all the experiments, I analysed the data and wrote the manuscript with the Group Leader, Dr J. Briscoe
Collaborator Contribution I initiated the collaboration. Used transgenic mice and plasmid constructs from the collaborating lab. Collaborating lab bred the transgenic mouse lineProvision of plasmid reagents, transgenic mouse lineProvision of reagents including transgenic mouse line
Impact Original article in the journal 'Nature Neuroscience' (see Publications). Collaboration expanded the range of model organisms used in the study.
Start Year 2006
 
Description Regulation of neurotransmitter phenotype by Insm1 and Mash1 
Organisation College of Sciences
Department Department of Biology
Country United States of America 
Sector Academic/University 
PI Contribution Performed most experiments, analysed data and wrote manuscript
Collaborator Contribution Provision of antibody and plasmid reagents, mouse linesTraining in biochemical/molecular biology techniquesProvision of transgenic mouse line
Impact Original article published in the journal 'Development'
Start Year 2008
 
Description Regulation of neurotransmitter phenotype by Insm1 and Mash1 
Organisation Helmholtz Association of German Research Centres
Department The Max Delbrück Center for Molecular Medicine (MDC)
Country Germany, Federal Republic of 
Sector Academic/University 
PI Contribution Performed most experiments, analysed data and wrote manuscript
Collaborator Contribution Provision of antibody and plasmid reagents, mouse linesTraining in biochemical/molecular biology techniquesProvision of transgenic mouse line
Impact Original article published in the journal 'Development'
Start Year 2008
 
Description Regulation of neurotransmitter phenotype by Insm1 and Mash1 
Organisation Medical Research Council (MRC)
Department MRC National Institute for Medical Research (NIMR)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution Performed most experiments, analysed data and wrote manuscript
Collaborator Contribution Provision of antibody and plasmid reagents, mouse linesTraining in biochemical/molecular biology techniquesProvision of transgenic mouse line
Impact Original article published in the journal 'Development'
Start Year 2008
 
Description Retinoid Regulation of Ascl1 Expression Level Determines Neuronal Fate 
Organisation School of Medicine UCLA
Department Department of Neurobiology
Country United States of America 
Sector Academic/University 
PI Contribution Initiiated and led this collaboration.
Collaborator Contribution Provided transgenic mouse tissue for analysis in UK
Impact Manuscript under review
Start Year 2010
 
Description Retinoid Regulation of Ascl1 Expression Level Determines Neuronal Fate 
Organisation University of Kyoto
Department Institute for Virus Research
Country Japan 
Sector Academic/University 
PI Contribution Initiiated and led this collaboration.
Collaborator Contribution Provided transgenic mouse tissue for analysis in UK
Impact Manuscript under review
Start Year 2010
 
Description Review of temporal patterning in the nervous system 
Organisation Medical Research Council (MRC)
Department MRC National Institute for Medical Research (NIMR)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution I initiated the collaboration. I co-authored the manuscript.
Collaborator Contribution Joint review article co-authored by two other individuals including one PI in the collaborating lab
Impact 'Hypothesis' article in the journal 'Development'
Start Year 2008