The functions and neural mechanisms of the hippocampal formation in memory

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Molecular. Genetics & Pop Health

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications


10 25 50
publication icon
Bethus I (2010) Dopamine and memory: modulation of the persistence of memory for novel hippocampal NMDA receptor-dependent paired associates. in The Journal of neuroscience : the official journal of the Society for Neuroscience

publication icon
Chen G (2007) Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid. in The Journal of neuroscience : the official journal of the Society for Neuroscience









 
Description Framework 7
Amount £363,585 (GBP)
Organisation Community Research and Development Information Service (CORDIS) 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 02/2008 
End 01/2013
 
Description Human Frontiers Science Programme
Amount £155,680 (GBP)
Organisation Human Frontier Science Program (HFSP) 
Sector Charity/Non Profit
Country France, French Republic
Start 10/2006 
End 09/2010
 
Title Temperature device 
Description We have developed temperature controller software that will monitor and control the full electrophysiology rig and provide the capability to run acute-slice experiments overnight. In a brain slice chamber the conventional heater can cause droplets of condensation from the fluid filled chamber to form on the cooler electrodes and consequently limit the time available to collect brain slice recording. Rather than controlling the heating of the slice chamber, the temperature software controller maintains the temperature of everything within the insulated rig. The temperature of the oxygenated air, the brain slice, the electrodes and the remaining rig equalise providing a stable environment for long-term recordings. Example: the temperature can be maintained at a constant 32 degrees and extend the length of slice viability to times that allow investigations of long-term changes in synaptic connectivity. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2009 
Provided To Others? Yes  
Impact Much better electrophysiological recording in brain slice experiments. 
 
Description MEMOLOAD 
Organisation Biocenter Oulu
Country Finland, Republic of 
Sector Academic/University 
PI Contribution Provision of behavioural expertise in study of animal models of Alzheimer's Disease.
Collaborator Contribution Scientific meetings and publications over the period of the grant.
Impact None yet.
Start Year 2008
 
Description Synaptic Tagging 
Organisation Graduate School of Medicine
Department Department of Biophysics & Biochemistry
Country Japan 
Sector Academic/University 
PI Contribution We provided behavioural and electrophysiological expertise to the project.
Collaborator Contribution Joint research using interdisciplinary techniques and shared publicationsJoint research using interdisciplinary techniques and shared publications
Impact 1. Redondo et al - J Neuroscience 2010 paper (on publications list) 2. Barrett et al - PLoS Computational Biology paper (on publications list) 3. Developmental of device for maintaining accurate temperature of brain slices during long-time course physiology studies.
Start Year 2007
 
Description Synaptic Tagging 
Organisation Max Planck Society
Department Max Planck Martinsried
Country Germany, Federal Republic of 
Sector Academic/University 
PI Contribution We provided behavioural and electrophysiological expertise to the project.
Collaborator Contribution Joint research using interdisciplinary techniques and shared publicationsJoint research using interdisciplinary techniques and shared publications
Impact 1. Redondo et al - J Neuroscience 2010 paper (on publications list) 2. Barrett et al - PLoS Computational Biology paper (on publications list) 3. Developmental of device for maintaining accurate temperature of brain slices during long-time course physiology studies.
Start Year 2007
 
Description School Activity, Edinburgh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact 180 pupils attended a workshop 'How we see the brain and what the brain sees' where they learned about the structure of the brain, how we image it, and how the brain processes visual information.


Pupils and teachers were very enthusiastic and have asked for similar events.
Year(s) Of Engagement Activity 2006,2007