ALSPAC: A reference population for genetic & environmental epidemiology

Lead Research Organisation: University of Bristol
Department Name: Social Medicine

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Avon Longitudinal Study of Pregnancy & Childhood (ALSPAC) is a recent population-based study designed to understand the ways in which the physical and social environment interact, over time, with the genotype to affect health, behaviour and development. The ALSPAC design offers special advantages, the most important being - enrolment in early pregnancy, banking of DNA from the children and parents (permitting genetic transmission tests and transgenerational imprinting studies); diverse environmental measures both physical and psychological; one geographical base (permitting medical record and school linkage; environmental measures in the home, and clinics for direct examination); an intensely studied 10% subset - the Children in Focus (permitting detailed hands-on follow-up, validation of questionnaire data from the cohort, and practice for the 7-8 year examinations on the full cohort). The 14,893 enrolled pregnancies (EDD 1.4.91 - 31.12.92) represented about 85% of the eligible population and 14,138 children (13,995 mothers) are being followed principally by questionnaires completed by parents (227,151 returned of the 280,373 sent) with plans for a ‘physical examination at 7 years and a ‘psychological‘ one at 8 years. A study of this complexity is highly collaborative (including topic-specific international workshops) and the academic cohesion needed to fully exploit this valuable national resource would be enhanced by acceptance as a Co-operative Group.

Organisations


Publications


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Adgent MA (2011) Early-life soy exposure and gender-role play behavior in children. in Environmental health perspectives





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Allely CS (2013) Parent-infant vocalisations at 12 months predict psychopathology at 7 years. in Research in developmental disabilities





 
Description ALSPAC contributes lung-function data to Global Lungs Initiative
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL http://www.lungfunction.org/
 
Guideline Title Chief Medical Officer's Update 36, Department of Health
Description ALSPAC research leads to change in peanut packaging
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
URL http://webarchive.nationalarchives.gov.uk/+/www.dh.gov.uk/en/Publicationsandstatistics/Lettersandcir...
 
Description Breastfeeding findings endorsed by Unicef
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL http://www.unicef.org.uk/BabyFriendly/News-and-Research/Research/Blood-pressure/Breastfeeding-is-ass...
 
Description Child protection policy cited as example of best practice
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
 
Description Disclosure policy used as example of best practice
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
 
Description Founding member of the Cohorts and Longitudinal Studies Enhancement Resource (CLOSER)
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
URL http://www.closer.ac.uk/
 
Description Influenced US policy on fish consumption vs. mercury content, as well as
Geographic Reach North America 
Policy Influence Type Gave evidence to a government review
URL http://europepmc.org/abstract/MED/17307104
 
Description Questionnaires used as examples of best practice
Geographic Reach North America 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Roulstone communications research endorsed by 'Hello' campaign and referenced in Nutbrown independent report to Government on early years learning
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/175463/Nutbrown-Review.pdf
 
Description Swimming in chlorinated pools does not lead to risk of asthma
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description 23 & Me Incorporated B848 RY9232 'Genotyping of ALSPAC cohort.'
Amount £20,000 (GBP)
Organisation 23andMe 
Sector Private
Country United States of America
Start 01/2010 
End 12/2010
 
Description 23&Me Incorporated RY9251
Amount £44,533 (GBP)
Organisation 23 & Me 
Sector Private
Country Unknown
Start  
 
Description A genome based recall pilot study to compare use of liver enzymes, ultrasound scan and magnetic resonance imaging for identifying non-alcoholic fatty liver disease in epidemiological studies.
Amount £58,413 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description ALSPAC and adolescent substance use trajectories: consolidation of a UK research source.
Amount £152,902 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description Arthritis Research Council Project Grant RJ4943 'Is joint hypermobility a risk factor for the development of chronic musculoskeletal pain'
Amount £79,759 (GBP)
Organisation Arthritis Research UK 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2008 
End 03/2011
 
Description Asthma UK project grant B202 RJ4728 'Can occupation influence development of asthma & respiratory symptoms in partners & children'
Amount £13,780 (GBP)
Organisation Asthma UK 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2006 
End 03/2008
 
Description BHF Special Project B310 SSCM.RJ4966 'Obstetric, lifestyle & genetic determinants of atherosclerosis, fat mass, insulin, glucose & lipid levels in women in early middle age.'
Amount £795,450 (GBP)
Funding ID SP/07/008/24066 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 07/2008 
End 06/2012
 
Description BUPA Research Grant B253 SSCM.RJ4668 'Predicting persistence, resolution & outcome of stuttering in children in ALSPAC'
Amount £74,507 (GBP)
Organisation BUPA 
Department BUPA Foundation
Sector Private
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2006 
End 09/2007
 
Description British Heart Foundation Project grant B300 RJ4789 'Growth related effects in ALSPAC on cardiac endpoints (GRACE)'
Amount £44,614 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2006 
End 06/2010
 
Description British Scoliosis Research Foundation B727 RJ5290 'An investigation into the determinants of scoliosis induction & progression & its impact on older children, using a large prospective pop-based cohort'
Amount £13,536 (GBP)
Organisation British Scoliosis Research Foundation (BSRF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2010 
End 12/2011
 
Description British Thyroid Foundation B904 Taylor 'Common variation in thyroid hormone bioavailability - effects on key health outcomes'
Amount £3,011 (GBP)
Organisation British Thyroid Foundation (BTF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2012 
End 12/2012
 
Description C.Williams Career Development Fellowship NIHR - B775 SSCM.RK7096 'Fellowship: Functional vision in children with disabilities and/or learning disabilities'
Amount £68,365 (GBP)
Organisation University College London Hospitals Charity (UCLH) 
Department National Institute for Health Research (NIHR)
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2010 
End 12/2014
 
Description CHICOS Developing a Child Cohort Research Strategy for Europe (1.5m euros across 9 participants)
Amount £135,767 (GBP)
Organisation European Commission (EC) 
Sector Public
Country European Union (EU)
Start  
 
Description Characterising patterns and determinants of smoking initiation in adolescence.
Amount £620,016 (GBP)
Organisation Brain Research Trust (BRT) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description DOUBLE ENTRY CANNOT FIND OUT HOW TO DELETE
Amount £35,000 (GBP)
Organisation Economic and Social Research Council (ESRC) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2016 
End 07/2017
 
Description Deafness UK B754 RJ5280 'An investigation of audiological and gastrointestinal phenotypes in GJB2 carriers. Is there phenotypic evidence for heterozygote advantage?'
Amount £10,585 (GBP)
Organisation The Royal National Institute For Deaf People 
Department Action on Hearing Loss
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2010 
End 06/2011
 
Description DfE ALSPAC Education Project B889 RK6738 'Enhancement of ALSPAC data collection at age 18'
Amount £723,171 (GBP)
Funding ID EOR/SBU/2002/1211 
Organisation Faculty of Education & Society 
Department Department of Education
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2006 
End 03/2012
 
Description Diagnoptics - AGE readers for field use (Recall by Genotype) in the MRC IEU
Amount £50,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 02/2017 
End 05/2017
 
Description Dietary determinants of fat mass in adolescents.
Amount £93,863 (GBP)
Organisation Agency for Science, Technology and Research (A*STAR) 
Sector Public
Country Singapore, Republic of
Start  
 
Description Do measures in blood cord predict long term offspring phenotype
Amount £497,019 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description ESRC B468 RC1415 'Development Trajectories of depressive symptoms from late childhood to early adolescence: impact of gender, puberty and adversity'
Amount £65,660 (GBP)
Organisation Economic and Social Research Council (ESRC) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2008 
End 12/2009
 
Description ESRC special grant B326 AC1025 'Depositing of defined ALSPAC data sets with the UK Survey Archive'
Amount £149,566 (GBP)
Organisation Economic and Social Research Council (ESRC) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2007 
End 12/2008
 
Description Early life determinants of blood pressure patterns in young adults
Amount £495,353 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description Elizabeth Blackwell Institute (University of Bristol) award with contribution from the Wellcome Trust's Institutional Strategic Support Fund
Amount £7,462 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2013 
End 12/2014
 
Description Elizabeth Blackwell Institute Extension Fellowship (Leila Thuma)
Amount £46,467 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2016 
End 08/2017
 
Description Elizabeth Blackwell Institute Postgraduate Extension Scheme (Michelle Taylor)
Amount £32,817 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2016 
End 06/2017
 
Description FP7 MCP HEALTH B483 SSCM.RQ8619 C'ONTAMED: Contaminant mixtures & human reproductive health'
Amount € 140,512 (EUR)
Funding ID 212502 
Organisation European Commission (EC) 
Sector Public
Country European Union (EU)
Start 12/2007 
End 10/2012
 
Description Fellowship NIHR - B417 SSCM.RK7065 'Adolescent eating disorders and related behaviour'
Amount £44,380 (GBP)
Funding ID PACKBVA/PCCKBVA 
Organisation University College London Hospitals Charity (UCLH) 
Department National Institute for Health Research (NIHR)
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 09/2008 
End 08/2011
 
Description Genome-Wide assosciation study SSCM. RJ5210
Amount £20,274 (GBP)
Funding ID 88806 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2009 
End 06/2012
 
Description Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes
Amount £2,306,620 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description Influences on psychosocial & physical health in early adulthood: phenotypic enrichment of the ALSPAC cohort through linkage to primary care electronic patient records & other databases PEARL project B557
Amount £1,686,058 (GBP)
Funding ID 086118 OAFI 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2009 
End 03/2013
 
Description John Davis Foundation USA (donation J Davis) B930 'Replicating GWAS association with alcohol phenotypes'
Amount £28,380 (GBP)
Organisation Cora and John H Davis Foundation 
Sector Charity/Non Profit
Country United States of America
Start 06/2010 
End 05/2011
 
Description Lifelong Health & Wellbeing (LLWH) - Research award B1193 SSCM.RD1748 'Understanding the lifestyle, molecular and genetic pathways that link women's reproductive function to healthy ageing'
Amount £592,447 (GBP)
Funding ID G1001357/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2011 
End 09/2016
 
Description Luisa Zuccolo (Post Doctoral  Research Fellow).  Prenatal alcohol exposure, childhood development and teenage drinking: a study of trans-generational effects.
Amount £417,352 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description MRC Proximity to Discovery Industry Engagement Fund (Tom Richardson)
Amount £12,225 (GBP)
Organisation MRC-UK 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 08/2016 
End 05/2017
 
Description MRC Research Grant (The effect of common disease associated genetic variants on transcriptomic and early life phenotypes)
Amount £404,251 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description MRC Research Grant (The public health importance of vitamin D: the causal effect of interauterine and lifetime exposure to vitamin D on metabolic and vascular traits)
Amount £1,280,070 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description MRC Research Grants B176 RD1605 'Natural history of asthma'
Amount £246,316 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2006 
End 09/2010
 
Description MRC Research Grants B256 RD1624 'The origins, outcomes & impact of persisting phonological impairment'
Amount £85,049 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2006 
End 02/2007
 
Description MRC Sterne G0600599/Medical Research Counch
Amount £242,080 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2007 
 
Description March of Dimes Foundation B258 RX9139 'A comprehensive study of genetic susceptibility to preterm delivery'
Amount £40,594 (GBP)
Organisation March of Dimes Foundation 
Sector Charity/Non Profit
Country United States of America
Start 03/2006 
End 02/2009
 
Description Medical Research Council (CAITE) B771 RD1634 'Epigenetics pilot. A supplement to the MRC CAiTE Centre grant'
Amount £3,443 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 09/2009 
End 08/2015
 
Description Medical Research Council (MRC) B734 RD1694 'ALSPAC & adolescent substance use trajectories: consolidation of a UK research resource'
Amount £61,982 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2009 
End 03/2011
 
Description Medical Research Council B264 RD1683 'Causal pathways to substance use & dependence in young people'
Amount £423,670 (GBP)
Funding ID G0800612 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2008 
End 11/2011
 
Description Medical Research Council B542 RD1664 'Psychotic symptoms in ALSPAC cohort at age 17'
Amount £873,539 (GBP)
Funding ID G0701503 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 07/2008 
End 03/2013
 
Description Milk, dairy products, and calcium intakes in children: prospective associations with body mass composition measured using dual-energy X-ray absorptiometry $351952
Amount £228,431 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start  
 
Description Modifiable early life determinants of adolescent NAFLD and its association with metabolic and vascular traits
Amount £130,493 (GBP)
Funding ID PG/11/33/28794 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description Molecular, Genetic and Lifecourse Epidemiology
Amount £1,350,000 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2016 
End 10/2019
 
Description National Clinical Sciences Award B161 RJ4706 'Investigating genetic & environment risk factors for sub-clinical psychosis-like symptoms (PLIKS) in a birth cohort '
Amount £202,167 (GBP)
Organisation University College London Hospitals Charity (UCLH) 
Department National Institute for Health Research (NIHR)
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2006 
End 09/2009
 
Description National Institutes of Health B305 RW9033 'Physical Activity, childhood obesity and risk of cardiovascular disease (continuation of programme grant)'
Amount £542,748 (GBP)
Funding ID 2 R01 HL071248-05A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 08/2007 
End 07/2011
 
Description Occurrence and determinants of adolescent Non-Alcoholic Fatty Liver Disease (NAFLD)
Amount £185,776 (GBP)
Organisation European Commission (EC) 
Sector Public
Country European Union (EU)
Start  
 
Description Population Research Committee - Programme Award Reducing the burden of cancer: causal risk factors, mechanistic targets and predictive biomarkers
Amount £4,100,000 (GBP)
Organisation Cancer Research UK (CRUK) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 06/2015 
End 05/2020
 
Description Programme Grant BHF B945 SSCM.RJ5410 'The impact of adiposity on risk profiles and the emerging arterial phenotype in the young'
Amount £34,384 (GBP)
Funding ID RG/10/004/28240 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 07/2010 
End 06/2015
 
Description Project award B752 SSCM. RJ5368 'Prevalence of hyperandrogenism in teenage girls & cardiovascular risk (ALSPAC & N. Finland cohorts)'
Amount £89,167 (GBP)
Funding ID 089549/Z/09/Z 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2010 
End 12/2012
 
Description R01 Reseach NIH - B731 SSCM.RW9047 'Modelling obesity through simulation (MOTS)'
Amount £16,648 (GBP)
Funding ID 5U01-HD061978-02 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 08/2009 
End 05/2014
 
Description RO1
Amount $3,184,226 (USD)
Funding ID 1R01HL132321-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 09/2016 
End 07/2021
 
Description Research (BOHRF) B1121- SSCM.RJ5684 'APPRaisal of the health of new ENTrants Into the workplaCE - the APPRENTICE study'
Amount £29,612 (GBP)
Funding ID BOHRF277E10 
Organisation British Occupational Health Research Foundation (BOHRF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 06/2011 
End 05/2013
 
Description Research - B847 ORDS.AX5022 'Eating Disorder phenotypes across adolescence in 2 longitudinal population cohorts
Amount $79,876 (USD)
Funding ID 1R01MH087786-01 
Organisation National Institutes of Health (NIH) 
Department National Institute of Mental Health (NIMH)
Sector Public
Country United States of America
Start 12/2009 
End 11/2013
 
Description Research Grant MRC - B709 SSCM.RD1736 'Structural brain correlates of an operationally defined high-risk phenotype for schizophrenia: a population based study'
Amount £214,015 (GBP)
Funding ID G0901885 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2010 
End 07/2013
 
Description Research Large Programme grant - B273 SSCM.RC1387 A'n examination of the impact of family socio-economic status on outcomes in late childhood and adolescence'
Amount £1,070,574 (GBP)
Funding ID RES-060-23-0011 
Organisation Economic and Social Research Council (ESRC) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2007 
End 03/2012
 
Description Research award MRC B1095 SSCM.RD1749 'Epidemiological studies of human transgenerational responses (TGR) to paternal and ancestral exposures'
Amount £23,051 (GBP)
Funding ID G1100226 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2011 
End 10/2013
 
Description Research award NIH - B990 SSCM.RW9085 'Epigenetic Pathways to Conduct Problem Trajectories: the Role of Prenatal and Postnatal Environmental Risk Exposures'
Amount $19,684 (USD)
Funding ID 1R01HD068437-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 02/2012 
End 01/2015
 
Description Research grant B525 SSCM.RD1665 'The public health importance of vitamin D: determining causal effects of intrauterine and lifetime exposure to Vitamin D'
Amount £977,089 (GBP)
Funding ID G0701603 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2008 
End 09/2012
 
Description Research grant B658 SSCM.RD1682 'Evaluating the utility of liver enzymes as biomarkers for non-alcoholic fatty liver disease in adolescents (NAFLD project).'
Amount £212,516 (GBP)
Funding ID G0801456 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 12/2008 
End 12/2012
 
Description Research grant MRC - B598 SSCM.RD1714 'Gene x gene & gene x environment interactions underlying speech, language & reading'
Amount £20,336 (GBP)
Funding ID G0800523 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2009 
End 01/2011
 
Description Responsible Gambling Fund B636 RJ5153 'Decision making and gambling behaviour in adolescence'
Amount £114,216 (GBP)
Organisation Responsible Gambling Trust 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2008 
End 12/2011
 
Description Strategic award Engaging Science - 75th Anniversary Award SSCM.RJ5645
Amount £5,000 (GBP)
Funding ID WT 092731/Z/10/Z 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2011 
End 09/2012
 
Description The Avon Longitudinal Study of Parents and Children: An international resource for population genomics and lifecourse epidemiology. Core Programme Support
Amount £6,000,000 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2011 
End 03/2014
 
Description The antecedents and consequences of gambling behaviour in adolescence: a prospective population study.
Amount £114,200 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Description The utility of biomarkers for non-alcoholic fatty liver disease in adolescents
Amount £548,636 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2009 
End 09/2012
 
Description Tourettes Syndrome Association B723 RX9178 'Evaluation of prenatal & perinatal risk factors for Tourette syndrome & chronic tic disorders in a large prospective population-based cohort .'
Amount £23,676 (GBP)
Organisation Tourette Syndrome Association (TSA) 
Sector Charity/Non Profit
Country United States of America
Start 07/2009 
End 06/2011
 
Description UK Department of Transport B331 RM8265 'Travel and accidents at age 13'
Amount £78,547 (GBP)
Organisation Government of the UK 
Department Department of Transport
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2008 
End 03/2010
 
Description US Army B758 RW9061'Placental vascular tree as a marker of autism/ASD risk '
Amount £28,430 (GBP)
Funding ID W81XWH-10-1-0626 
Organisation Government of the United States of America 
Department United States Armed Forces
Sector Public
Country United States of America
Start 05/2010 
End 04/2012
 
Description US National Institute for Health (NIH) B563 RX9171'Milk, dairy products & calcium intakes in children: prospective associations with body composition measured using dual-energy x-ray absorptiometry'
Amount £68,783 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 07/2008 
End 06/2011
 
Description US National Institute for Health (NIH) B648 RW9059 'Axon, testosterone and mental health during adolescence'
Amount £187,948 (GBP)
Funding ID 1R01MH085772-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 06/2010 
End 05/2015
 
Description US National Institute for Health B569 RW9057 'Pathways to alcohol use disorders in ALSPAC: a genetic-developmental study'
Amount £277,322 (GBP)
Funding ID 1R01AA018333-01A2 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 10/2010 
End 09/2015
 
Description US National Institutes for Health (NIH) B020 RW9009 'Persisting effects of prenatal anxiety on childhood outcomes'
Amount £459,758 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 06/2006 
End 03/2011
 
Description US National Institutes for Health (NIH) B303 RW9016 'Maternal over nutrition and offspring fat mass, metabolic and vascular function.'
Amount £557,500 (GBP)
Funding ID 1 R01 DK077659-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 02/2007 
End 01/2011
 
Description WCRF B129 SSCM.RJ4532 'Diet, IgF & Cancer risk
Amount £136,683 (GBP)
Organisation Breast Cancer Campaign (BCC) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2006 
End 09/2008
 
Description WCRF Project Jebb B522 'Dietary determinants of fat mass in adolescents'
Amount £10,703 (GBP)
Organisation Breast Cancer Campaign (BCC) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 02/2009 
End 01/2011
 
Description WCRF Research grant B261 RJ5299 'The relationship between dietary patterns and changes in body fatness & lean mass'
Amount £98,583 (GBP)
Funding ID 2009/23 
Organisation World Cancer Research Fund (WCRF) 
Sector Charity/Non Profit
Country Global
Start 03/2010 
End 03/2012
 
Description WT Biomedical Resource - B1299 SSCM.RJ5817 'TWINSUK (2012-2015) - An Epidemiological & Genomic Resource'
Amount £31,879 (GBP)
Funding ID WT099194/Z/12/2 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2013 
End 12/2014
 
Description WT Principal Research Fellowship award B379 SSCM.RJ5256 'Does impaired autobiographical memory mediate associations between traumatic life events in childhood & subsequent depression & self-harm?'
Amount £92,962 (GBP)
Funding ID 067797/Z/02/A 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 05/2008 
End 04/2013
 
Description WT Project award B485 SSCM.RJ5121 'Investigation of the influence of habitual levels of vigorous physical activity on skeletal strength in late adolescence'
Amount £190,729 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 09/2008 
End 10/2011
 
Description WT Project award B531 SSCM.RJ5092 'Depression at 17+'
Amount £446,047 (GBP)
Funding ID 084268/Z/07/Z 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2008 
End 03/2013
 
Description WT Project award B578 SSCM.RJ5162 'Genetic and environmental predictors of smoking initiation in adolescence.'
Amount £227,664 (GBP)
Funding ID 86684 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2009 
End 12/2011
 
Description WT Project award B614 SSCM.RJ5163 'Early life determinants of blood pressure patterns in young adults (ELBA)'
Amount £308,102 (GBP)
Funding ID 86676 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2009 
End 12/2011
 
Description WT Project award B837 SSCM.RJ5569 'Do Measures in Cord Blood Predict long term Offspring Phenotype'
Amount £74,103 (GBP)
Funding ID 094311/Z/10Z 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2011 
End 03/2014
 
Description WT Project grant - B389 SSCM.RJ5136 'Does mother's dietary intake during pregnancy influence brain development and therefore cognitive abilitiy?'
Amount £7,055 (GBP)
Funding ID WT084668MA 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 12/2008 
End 12/2012
 
Description WT Project grant - B489 Gray 'Effects of Prenatal Alcohol Consumption and Alcohol Metabolism Genes on Child Growth Neurodevelopment'
Amount £10,849 (GBP)
Funding ID WT083506/Z/07/2 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 03/2008 
End 02/2010
 
Description WT Project grant B701Humphrey 'Unlocking evidence of Infant and Maternal Health and Diet from Tooth Enamel'
Amount £2,558 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2012 
End 12/2015
 
Description WT Resource award B638 SSCM.RJ5193 'ALSPAC: Request for funds to enhance this detailed biomedical resource with obstetric & perinatal data from medical records'
Amount £121,384 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 05/2009 
End 04/2011
 
Description WT Strategic award SSCM.RJ5367 '10,000 UK genome sequence: accessing the role of rate genetic variants in health and disease'
Amount £104,030 (GBP)
Funding ID WT091310/Z/1 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2010 
End 03/2012
 
Description Wellcome Trust Intermediate Clinical Fellowship - B1184 Galobardes
Amount £329,640 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2010 
End 09/2014
 
Description Wellcome Trust Project Grant B304 RJ4650 'Investigation of the relationship between habitual levels of physical activity and cortical bone geometry in childhood'
Amount £137,585 (GBP)
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2006 
End 09/2009
 
Description World Universities Network Research Development Fund - Workshop on sharing sensitive data
Amount £25,028 (GBP)
Organisation Worldwide Universities Network (WUN) 
Sector Academic/University
Country Global
Start 08/2016 
End 08/2017
 
Title ALGAE 
Description ALGAE is an automated protocol which can be used to assess historical exposures to air pollution for members of longitudinal cohorts. It was developed as part of a research project between Imperial College's Small Area Health Statistics Unit (SAHSU) and the Avon Longitudinal Study of Parents and Children (ALSPAC). 
Type Of Material Improvements to research infrastructure 
Year Produced 2016 
Provided To Others? Yes  
Impact No measurable impact to date but provides a solution to geographical mapping of historical address data from cohorts to environmental exposures & will be of generic value to all cohorts with these data. 
URL https://github.com/smallAreaHealthStatisticsUnit/algae
 
Title Arcadia 
Description Arcadia is database that has been developed to maintain all the records of ALSPAC's research participants. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact None. 
 
Title Biobanking and sample analysis methodology 
Description Development of methods for processing blood and tissue (e.eg. placenta) 
Type Of Material Biological samples 
Provided To Others? No  
Impact n/a 
 
Title Cell lines 
Description A lymphoblastoid cell line bank derived from study participants has been developed. Over 11,000 cell lines have been established and are available for research (total anticipated 16,000 on children, mothers and partners). The cell lines are proving to be an invaluable source of material for several studies. Expression analysis has been completed using cell lines from 1000 study children for whom genome-wide genotyping data is available. Samples are also being used for in vitro assays relating protein expression to individual genotypes. The cell lines are also used to replenish our DNA bank ensuring enough material is available for genome-wide genotyping studies. One aliquot of all transformed cells are stored at ECACC, Health Protection Agency, Porton Down in their secure cell line storage facility. 
Type Of Material Cell line 
Year Produced 2008 
Provided To Others? Yes  
Impact Currently, all projects using this material are underway. 
 
Title DNA resource 
Description ALSPAC DNA resource currently contains DNA from 11,343 children and 10,433 mothers. The samples have been supplied for numerous genotyping studies including genome-wide association studies, sequencing projects (UK10K) and epigenetic studies. 
Type Of Material Biological samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Use of the DNA resource has led to numerous publications. 
 
Title Laboratory Information Management Systems (LIMs) 
Description Laboratory Information Management System (LIMS) - continually under development. Genotype Database - almost developed and allows automated generation of quality control reports of genotyping data. 
Type Of Material Biological samples 
Provided To Others? No  
Impact Many collaborations set up. 
 
Title Longitudinal data collection methodology 
Description ALSPAC is increasingly seen as an international lead with respect to running a large birth cohort and making data widely available for effecient use by scientists from a wide-range of disciplines. 
Type Of Material Biological samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Adoption of ALSPAC study methods by the Born in Bradford cohort. 
 
Title Management of clinical information within a whole genome sequence project 
Description This work considers and advises on how to handle data which is clinically important within the context of a whole genome sequence project. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work has been published: Eur J Hum Genet. 2014 Sep;22(9):1100-4. doi: 10.1038/ejhg.2013.290. Epub 2014 Jan 15. Managing clinically significant findings in research: the UK10K example. Kaye J1, Hurles M2, Griffin H1, Grewal J3, Bobrow M4, Timpson N5, Smee C2, Bolton P6, Durbin R2, Dyke S2, Fitzpatrick D7, Kennedy K2, Kent A8, Muddyman D2, Muntoni F9, Raymond LF4, Semple R4, Spector T10; UK 10K. 
 
Title Pooling of children's physical activity data 
Description Professor C Riddoch (close collaborator) at the University of Bath won a Phase 2 NPRI award to pool children's physical activity data from a large number of cohorts/studies including ALSPAC 
Type Of Material Biological samples 
Provided To Others? No  
Impact This project is still underway, so no impacts at present. 
 
Title Power calculations for the undertaking of genetic sequence analysis of rare variants. 
Description This work provides a framework within which power calculations for the analysis of rare variants from genetic sequence data can be undertaken. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact NA 
URL http://onlinelibrary.wiley.com/doi/10.1002/gepi.21797/abstract
 
Title Protocol for recall by genotype study - sleep 
Description This work provides a framework within which recall by genotype studies can be undertaken. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This description is now published: BMC Med Genet. 2015 Oct 24;16:96. doi: 10.1186/s12881-015-0244-4. Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology. 
URL http://www.biomedcentral.com/1471-2350/15/13
 
Title Protocol for recall by genotype study - smoking 
Description This work provides a written protocol for the undertaking of recall by genotype studies. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work is now published: BMC Med Genet. 2014 Jan 22;15:13. doi: 10.1186/1471-2350-15-13. A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: study protocol. Ware JJ1, Timpson N, Davey Smith G, Munafò MR. 
 
Title Recall by Genotype Study Planner - app 
Description This is an online "shiny app" which is designed to accompany a position paper describing the principal and application of Recall by Genotype as a research method. It allows the calculation of statistical power and study cost (in comparison to other more conventional designs) in a series of study formats. 
Type Of Material Improvements to research infrastructure 
Year Produced 2016 
Provided To Others? Yes  
Impact This research tool will be released in full form with the publication of the Recall by Genotype position paper. 
 
Title Statistical methodological developments for dealing with missing data in analyses 
Description ALSPAC is at the forefront of statistical methodological developments for dealing with missing data and using repeatedly collected longitudinal data. The need to deal with missing data in analyses is increasingly recognised, using for example multiple imputation or weighting methods to reduce bias caused by missingness, with an MRC funded project on ALSPAS driving this work. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact These methodological developments will be key to maintaining and developing ALSPAC and will also inform approaches to analysis of data in other UK and international cohorts. 
 
Title Web resource for the provision of UK10K sequence data, the display of results, related information and ethical documentation. 
Description This resource provides a collection of material from the UK10K project which involved the sequencing of over 4000 population based human genomes. Resources include: (i) access to raw data (ii) results from association study analysis (rare and common genetic variants) through an integrated browser (iii) ethical documentation (iv) related publications and management information 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact NA 
URL http://www.uk10k.org
 
Description "Bullying and cardiovascular and respiratory diseases" (B2281) 
Organisation University of Basel (Universität Basel)
Country Switzerland, Swiss Confederation 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description 'Identifying genetic variants influencing maternal health (morning sickness and breastfeeding) (B2290) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision - funding dependent
Collaborator Contribution seeking funds for secondary analysis
Impact n/a
Start Year 2014
 
Description 'Placental spaces': the social history of investments in a regional placenta tissue collection (B1229) 
Organisation University of the West of England
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Access to samples and participants
Collaborator Contribution Access to samples and participants
Impact n/a
Start Year 2011
 
Description 1000 Genomes imputattion of 79 odd variants and its association with asthma. 
Organisation University of Queensland
Department Queensland Institute of Medical Research QIMR
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal pending).
Start Year 2012
 
Description 1958 management - 2011 onwards (B1234) 
Organisation University of Leicester
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution PROVISION OF DATA
Collaborator Contribution PROVISION OF DATA
Impact EALRY STAGES
Start Year 2011
 
Description 23 and Me 
Organisation 23andMe
Country United States of America 
Sector Private 
PI Contribution Initial collaboration between MRC IEU on start up of Unit
Collaborator Contribution Initial collaboration between MRC IEU on start up of Unit
Impact Too early to list outputs or outcomes
Start Year 2013
 
Description 2D:4D digit ratio and autistic traits (B2130) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact paper submitted
Start Year 2014
 
Description A GENOMIC CONSORTIUM OF PSYCHOTIC EXPERIENCES IN ADOLESCENTS AND YOUNG ADULTS (B2139) 
Organisation Birkbeck University of London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution none yet - funding dependent
Collaborator Contribution none yet - funding dependent
Impact none yet
Start Year 2014
 
Description A Mendelian Randomisation Study of the effect of dietary milk intake & calcium on BMD and metabolomic variables (B2262) 
Organisation University of Queensland
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description A Mendelian Randomization Study of Iron Status, ADHD, and IQ (B1262) 
Organisation King's College London (KCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution provision of data
Collaborator Contribution interpretation of data
Impact early stages
Start Year 2011
 
Description A candidate gene approach for identifying genetic factors associated with height growth velocity in children (B1238) 
Organisation National University of Singapore
Country Singapore, Republic of 
Sector Academic/University 
PI Contribution PROVISION OF DATA
Collaborator Contribution PROVISION OF DATA
Impact EARLY STAGES
Start Year 2011
 
Description A case control epigenomic study to identify differentially methylated regions associated with rheumatoid arthritis. 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description A comparison of twin and singleton data for early life characteristic (B2005). 
Organisation University College London (UCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description A large-scale haplotype reference resource (UK10K) - B2034. 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Charity/Non Profit 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description A life-span approach to understanding risk gene contributions to Alzheimer's disease (B1477). 
Organisation Cardiff University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2012
 
Description A proof of principle approach of sparse structure learning & instrumental variable analyses of adiposity related traits. 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description A statistical framework to identify associations between diet and disease; a formal comparison of competing approaches (B1464). 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2012
 
Description A statistical toolbox for modelling accelerometer measured physical activity. 
Organisation Faculty of Science
Department Department of Mathematical Sciences
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description A whole genome study of the genetics of ankylosing spondylitis. 
Organisation University of Queensland
Department University of Queensland Diamantina Institute (UQDI)
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description ALSPAC Age 17 data - top line findings. 
Organisation Department for Education
Department Strategic Analysis and Research
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description ALSPAC Epigenomics Strategic Award 2014 (B2164) 
Organisation Wellcome Trust Sanger Institute
Department Medical Research Council (MRC) Integrative Epidemiology Unit at the University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Funding failed so no contribution
Collaborator Contribution Funding failed so no contribution
Impact nothing
Start Year 2014
 
Description ALSPAC Ethics and Law Committee: the first 16 years of ethical protection for an epidemiological birth cohort (B1185). 
Organisation Avon Longitudinal Study of Parents and Children (ALSPAC)
Department ALSPAC Ethics & Law Committee (ALEC)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Only archived ALSPAC Ethics & Law Committee documents.
Collaborator Contribution Only archived ALSPAC Ethics & Law Committee documents.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description AN EXPLORATION OF EXPERIENCE AND ENGAGEMENT IN A BIRTH COHORT/ BIOBANK: A QUALITATIVE STUDY (B2175) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Supporting access particiapants for qualitative research study
Collaborator Contribution New data generation through qualitative interviews
Impact none yet
Start Year 2014
 
Description APOE and working memory at 17 (B1511). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Acne, Adolescent Mental Health and Educational Attainment. 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Adolescent active and passive tobacco exposure and cardiometabolic health (B1244) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution DATA PROVIDED
Collaborator Contribution DATA INTERPRETTED
Impact EAR;Y STAGES
Start Year 2011
 
Description Adolescent and peer smoking trajectories. 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Affective cognitive control and depression: creating a new evidence base for prevention (B2244) 
Organisation University College London (UCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision - secondary analysis
Collaborator Contribution seeking funds for secondary analysis
Impact n/a
Start Year 2014
 
Description Ageing lungs in European cohorts (ALEC) (B2194) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision - funding dependent
Collaborator Contribution seeking funds for secondary analysis
Impact n/a
Start Year 2014
 
Description Aid SAM project, Antibiotics influence on obesity and cardio-metabolic disease - Sustainability of healthy Microbiome (B2121) 
Organisation Frederiksberg Hospital
Country Denmark, Kingdom of 
Sector Hospitals 
PI Contribution None yet - await funding
Collaborator Contribution None yet - await funding
Impact none yet
Start Year 2013
 
Description Alastair Poole - University of Bristol, Physiology and Pharmacology 
Organisation University of Bristol
Department School of Physiology & Pharmacology Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution In a phenotype based recall examination of the impact of DNA methylation on the function of platelets (given existing findings around the implications of smoking for biological function and gene regulation), we have provided access to genetic data and a working set of participants for the undertaking of the study (along with the original motivation for this work).
Collaborator Contribution Our collaborators (Poole and colleagues) have provided expertise in the collection and analysis platelet function data (as collected from the examination of whole blood samples).
Impact NA
Start Year 2013
 
Description Alcohol and substance use: risk, development, and desistance during transitions to adulthood. (B1311) 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Alcohol consumption and cardiovascular health in adolescents (B1506). 
Organisation University College London (UCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Alcohol harms in the family (B2081). 
Organisation University of Sheffield
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Allergy and mental well-being in childhood. 
Organisation University of Bristol
Department Avon Longitudinal Study of Parents and Children (ALSPAC)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description An exploration of picky eating behaviour in ALSPAC (B2026). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description An investigation into the confounding associated with genome-wide score and methods to minimise its impact (B2091). 
Organisation University College London (UCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description An investigation of connexin-26 genetic mutations and hearing in the ALSPAC cohort B754 
Organisation University of Bristol
Department Centre for Multilevel Modelling (CMM)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact Publications
Start Year 2008
 
Description An obesogenic dietary pattern and cardiovascular risk factors in ALSPAC (b1256) 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Group
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution provision of data
Collaborator Contribution interpretation of data
Impact early stages
Start Year 2011
 
Description Analyses of Disparity in Energy intake, Metabolism and Adiposity (ADEMA): A genome-wide association study (B2028). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Analysis of 4 SNPs associated with permanent tooth eruption in additional growth phenotypes (B1126). 
Organisation The State Serum Institute (SSI)
Country Denmark, Kingdom of 
Sector Public 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Analysis of correlation patterns in DNA methylation through the lifecourse (B2097). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Analysis of the risk profiles of ALSPAC adolescent communities and individuals within a friendship network context. 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Androgens in maternal serum during gestation and child androgen levels in autism spectrum conditions and autistic traits (B2069). 
Organisation University of Cambridge
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Antecedents and correlates of adolescent gambling behaviour at age 17 (B1266) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution PROVISION OF DATA
Collaborator Contribution INTERPRETATION OF DATA
Impact EARLY STAGES
Start Year 2011
 
Description Antenatal depression and cardiometabolic risk in offspring. 
Organisation Mailman School of Public Health
Department Department of Epidemiology
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact Work already being done and therefore the applicants have withdrawn the application.
Start Year 2012
 
Description Antenatal interpersonal sensitivity, depression and subsequent mother-infant relationship quality (B2066). 
Organisation University of Sydney
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Antisocial and callous behaviour: the role of fish intake and their associated fatty acids (B2054). 
Organisation University of Illinois
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Applying MR to define risk factors causally related to lung cancer and their potential mediation by DNA methylation (B2161) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Are the age pattern of BMI development, overweight and obesity different in different settings? (B2251) 
Organisation Aarhus University
Country Denmark, Kingdom of 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Assessing disease by self-report in the 2014 ALSPAC children questionnaire mail out (B2174) 
Organisation University of Queensland
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution New data collection in Q going out to original cohort at end of 2014
Collaborator Contribution Provided funds for new data collection
Impact none yet
Start Year 2014
 
Description Assessing linkage error and bias between ALSPAC and HES (B2063). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Assessing methylome changes across adolescence in gender-related switch of asthma (B1155). 
Organisation University of Southampton
Department Human Genetics and Genomic Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact Failed submission for funding.
Start Year 2011
 
Description Assessing the impact of partner smoking on cotinine levels in the ALSPAC mothers (B2056). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Assessment of growth delay in children with unilateral cleft lip and/or palate (B1517). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Association between infant sleep position and gross motor skills and intelligence in childhood. (b2189) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Association between mitrochondrial copy number and chronic stress (B2044). 
Organisation Wellcome Trust Centre for Human Genetics
Department DNA Sequencing Hub (Oxford)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Association between parental ages and offspring DNA methylation levels (b1239) 
Organisation Federal University of Pelotas (UFPel)
Country Brazil, Federative Republic of 
Sector Academic/University 
PI Contribution provision of data
Collaborator Contribution provision of data
Impact early stages
Start Year 2011
 
Description Association between paternally inherited GNAS SNP alleles and birth weight (B2077). 
Organisation Massachusetts General Hospital
Country United States of America 
Sector Hospitals 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Association between perinatal risk factors and child cognitive and emotional development (B2072). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Association between pubertal development and depressive symptoms in males from late childhood to early adulthood. 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Association of birth circumstances & experience of parental separation of young women with the risk of preterm delivery (B3166) 
Organisation NHS Tayside
Department Ninewells Hospital
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Hospitals 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Association of candidate genetic regions with the participation in excessive exercise. 
Organisation University of Utrecht
Department Rudolf Magnus Institute
Country Netherlands, Kingdom of the 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Association of early life infection with childhood growth measures and cognitive abilities. 
Organisation Mount Sinai Hospital (Canada)
Department Samuel Lunenfeld Research Institute
Country Canada 
Sector Hospitals 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Association of maternal and pre-pubertal 25-Hydroxyvitamin D with post-pubertal Anti-Müllerian Hormone in off-springs (B2196) 
Organisation University of Glasgow
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Association of maternal smoking and tooth eruption in ALSPAC (B1549). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Association of polymorphisms in 1L1RL1 pathway and asthma in children. 
Organisation University of Groningen
Department University Medical Center Gronigen
Country Netherlands, Kingdom of the 
Sector Hospitals 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal pending).
Start Year 2012
 
Description Association of the mu-opioid receptor and DRD2 genes with body weight in parents and children.(B1202) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact n/a
Start Year 2011
 
Description Association study of ANTXR2 (capillary morphogenesis gene) and TNFR1 with ankylosing spondylitis (B1461). 
Organisation University of Oxford
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2012
 
Description Associations between antenatal domestic violence and cord blood DNA methylation (B2232) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Associations between changes in DNA methylation and changes in adioposity (B1542). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Associations between early parenting, parental monitoring and adolescent risk behaviour 
Organisation University of Glasgow
Department MRC Social and Public Health Sciences Unit
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Multiple 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Associations between primary care measures and psychosis-like symptoms in the ALSPAC birth cohort (B1489). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Associations between trajectories of maternal depression, with child's cognition and later psychosis-related outcomes (B2032). 
Organisation Deakin University
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Associations of hypertensive disorders of pregnancy with adolescent offspring cardiac function and structure (B2099). 
Organisation Lund University
Country Sweden, Kingdom of 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Automated methods for data mining of causal associations in epidemiology (B1518). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description BRAINEAT (B1487). 
Organisation University of Toronto
Department Baycrest Centre for Geriatric Care
Country Canada 
Sector Hospitals 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Behavioural and neurophysiological effects of schizophrenia risk genes. (B1276) 
Organisation Cardiff University
Department MRC Centre for Neuropsychiatric Genetics and Genomics
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Beyond health care: Improving social, economic and health outcomes for young people with anxiety' (B2288) 
Organisation London School of Economics and Political Science (University of London)
Department Personal Social Services Research Unit
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Bidirectional reciprocal genome-wide Mendelian Randomization of Maternal Smoking and Conduct Disorder/ADHD. 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Big mama: huge problem for offspring cardiovascular health? (B2131) 
Organisation University of Amsterdam
Department University Medical Center Amsterdam
Country Netherlands, Kingdom of the 
Sector Hospitals 
PI Contribution data provivsion
Collaborator Contribution Nothing - not funded
Impact None - not funded
Start Year 2014
 
Description Bio-social enhancements to the Millennium Cohort Study (B2020). 
Organisation University of London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Biobehavioral pathways to adolescent substance use - investigations using genetically-informed data from ALSPAC (B2208) 
Organisation Brown University, USA
Country United States of America 
Sector Academic/University 
PI Contribution data provision - funding dependent
Collaborator Contribution seeking funds for secondary analysis
Impact n/a
Start Year 2014
 
Description Birmingham Phenome Centre 
Organisation University of Birmingham
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution The Phenome Centre Birmingham is a large metabolic phenotyping facility led by internationally-recognised metabolomics and clinical experts at the University of Birmingham, in collaboration with Birmingham Health Partners. The centre has been established as part of a UK Stratified Medicine initiative led by the Medical Research Council (MRC) to develop capacity and capability to perform large-scale metabolic phenotyping of the human population for stratified medicine. The centre will work towards improving healthy ageing and disease diagnosis and treatment to enhance patient outcome. The centre is providing a key collaborator in the collection of specific mass spectrometry data in experiments explicitly designed to explore the downstream implications of genetic mutations discovered in genomewide genetic association studies.
Collaborator Contribution The collection of detailed liquid chromatography mass spectrometry data on specific samples, the cleaning of raw data and the undertaking of preliminary analyses (this forms an ongoing collaborative relationship).
Impact na
Start Year 2016
 
Description Birth order and cardiovascular risk factors: a comparison between the Pelotas cohorts and ALSPAC. 
Organisation University of Bristol
Department MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Multiple 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Birth weight and metabolomics profiles through the life-course: meta-analysis of 20,000 people (B2226) 
Organisation Oulu University Hospital
Country Finland, Republic of 
Sector Hospitals 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Births out of wedlock and cognitive and social development throughout childhood: a quantative analysis. 
Organisation Institute for Fiscal Studies
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Charity/Non Profit 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Bivariate genome-wide association study of birth weight and endophenotypes related to five diseases in later life (B2276) 
Organisation University of Queensland
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Blood pressure effects on cognitive function and academic attainment in children (B1520). 
Organisation Loughborough University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Blood pressure regulation according to obesity status in childhood (B1171). 
Organisation Henri Poincaré University
Country France, French Republic 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Brain structure, function and associated outcomes in young adults born late-preterm (B1265) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution PROVISION OF DATA
Collaborator Contribution INTERPRETATION OF DATA
Impact EARLY STAGES
Start Year 2011
 
Description Breast cancer risk prediction using epigenetic biomarkers. 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact (Funding application unsuccessful).
Start Year 2012
 
Description CLOSER (B1220) 
Organisation University of London
Department Institute of Education
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Involved in leadership team, leading work packages on harmonisation of biological samples, contributing to work packages on harmonisation of geographical and SES data
Collaborator Contribution Involved in leadership team with 8 longituidnal cohorts
Impact na early stages
Start Year 2011
 
Description CLOSER SES DATA HARMONISATION (B2084). 
Organisation Institute for Fiscal Studies
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Charity/Non Profit 
PI Contribution The Cohorts and Longitudinal Studies Enhancement Resources (CLOSER) project aims to provide and document a range of key variables that have been harmonised across multiple UK birth cohorts to encourage cross-cohort research on longitudinal data sets and permit compatrisons across as well as within cohort studies. Due to the restrictions on using and holding ALSPAC data (particularly data obtained through linkage) it is our aim to derive standardised measures from education, income and social class variables that are harmonised with derived data from the other cohorts. These variables, once derived, will be deposited back to ALSPAC with accompanying documentation and will not specifically be used for research outputs at this point other than documenting summary statistics. As such, there are no exposure, outcome or confounding variables to outline. Documentation will be held by CLOSER and made readily available to researchers in an attempt to provide a suitable search platform for commonly requested variables and therefore encourage cross-cohort analysis of data.
Collaborator Contribution (See above).
Impact N/A (ongoing).
Start Year 2013
 
Description CLOSER work package one: Data harmonisation of measures of biological function and structure across the cohorts (B2048). 
Organisation Medical Research Council (MRC)
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description CNVs and psychosis-related neurodevelopmental phenotypes (B1253) 
Organisation Cardiff University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution provision of data
Collaborator Contribution interpretation of data
Impact ealry stages
Start Year 2011
 
Description Caesarean Delivery and Later Health Outcomes in Infancy and Childhood (B1268) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution PROVISION OF DATA
Collaborator Contribution INTERPRETATION OF DATA
Impact EARLY STAGES
Start Year 2011
 
Description Can hip DXA scans be used to identify genetic determinants of hip shape and osteoarthritis? 
Organisation University of Bristol
Department School of Clinical Sciences Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Cannabis misuse and adverse outcomes for young people. 
Organisation National Centre for Social Research (NatCen)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Cardiometabolic consequences of genetic inhibition of interleukin-1a/ß (B2293) 
Organisation University of Cambridge
Department School of Clinical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Cardiorespiratory outcomes in preterm infants. 
Organisation Cardiff University School of Medicine
Department Department of Child Health
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Case study: Combined analysis of maternal occupation and the risk of adverse birth outcomes across CHICOS birth cohorts (B1136) 
Organisation Government of Catalonia
Department Center for Research in Environmental Epidemiology (CREAL)
Country Spain, Kingdom of 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact Abandoned due to costing issues.
Start Year 2011
 
Description Causal inference of cannabis and tobacco with education variables within ALSPAC (B1261) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution PROVISION OF DATA
Collaborator Contribution INTERPREATATION OF DATA
Impact EARLY STAGES
Start Year 2011
 
Description Causal relationship between Vitamin D and childhood caries: A mendelian randomisation approach (B2305) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Changes in diet and weight gain in children. 
Organisation Duke-NUS Graduate Medical School
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Changes in oral health behaviour between childhood and adolescence- analysis of data from ALSPAC (b2187) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Characterisation of the microbial flora in children with cleft lip and/or palate (b2183) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution None yet - funding dependent
Collaborator Contribution seeking new funds for secondary analysis
Impact none yet
Start Year 2014
 
Description Characterisation of transgenerational determinants of disease risk induced by ancestral or early-life parental exposures (B2176) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution None yet - funding dependent
Collaborator Contribution Seeking funds for seconday analysis
Impact none yet
Start Year 2014
 
Description Characterising the genetic and dietary predictors of the size, frequency and timing of consumption and its health impact (B2207) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution new data collection in original cohort at clinic planned for June 2015
Collaborator Contribution seeking funds for new data collection
Impact n/a
Start Year 2014
 
Description Childhood Sexual Behaviour and Adolescent Sexual Orientation (B2302) 
Organisation University of Cambridge
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Childhood antisocial behavior and cardiometabolic risk. 
Organisation Columbia University
Department School of Public Health
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Childhood body size and growth and later risk of haemorrhagic stroke (B1541). 
Organisation University of Copenhagen
Country Denmark, Kingdom of 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Childhood diet and adolescent depression (B688) 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact Publication
Start Year 2008
 
Description Childhood dietary patterns obtained using cluster analysis and risk factors for CVD in ALSPAC (B2132) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact paper in preparation
Start Year 2014
 
Description Childhood neurodevelopmental factors and risk of psychotic-like symptoms in 12-year-olds: genetic variation and development (B1255) 
Organisation University of Melbourne
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution PROVISION OF DATA
Collaborator Contribution INTERPRETATION OF DATA
Impact EARLY STAGES
Start Year 2011
 
Description Children of Alcoholic parents: Cognition, Behaviour, Mental Health and Alcohol Use Trajectories (B2016). 
Organisation Cardiff University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Children of parents with depression: DANVA as a predictor of child psychopathology (B1510). 
Organisation McMaster University
Country Canada 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Children, young people and families using social work services: Patterns, outcomes and change. 
Organisation Cardiff University
Department School of Social Sciences
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Chronic irritability in ADHD: examining clinical and genetic links with depression (B2223) 
Organisation Cardiff University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Cognitive Function and Social Learning (B833) 
Organisation Harvard School of Public Health
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact Publication
Start Year 2009
 
Description Cohort comparison: Adiponectin polymorphisms in the Pelotas 1982 cohort and ALSPAC. 
Organisation Newcastle University
Department Institute of Genetic Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Collection of Objective Nicotine Exposure Biomarker Data in the Avon Longitudinal Study of Parents and Children (B1177). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Combined parental postnatal depression and its effect on children: a systematic review and meta-analysis 
Organisation University College London (UCL)
Department UCL Medical School
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal pending).
Start Year 2012
 
Description Communication difficulties, peer victimization and mental health (B2103). 
Organisation University of East Anglia
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Comparison of a developmental time series of expression against the expression individuals with autism spectrum disorder (b2195) 
Organisation Harvard University
Department Harvard Medical School
Country United States of America 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Comparison of methods to relate GWG to child BMI at age 7 (B1535). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Connecting early language and literacy skills to later reading and writing abilities and disabilities (B2257) 
Organisation University of the West of England
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution new data collection in subsample of original cohort - funding dependent
Collaborator Contribution seeking funds for new data collection in substudy
Impact n/a
Start Year 2014
 
Description Consortium of Adolescents Studies for the Genetics of Smoking and Nicotine Dependence (CASGEN) (B1237) 
Organisation University of Bristol
Department School of Experimental Psychology Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution provision of data
Impact early stages
Start Year 2011
 
Description Contribution of polar overdominance to the missing heritability of common complex diseases in humans (B1130) 
Organisation University of Liege
Department Unit of Animal Genomics
Country Netherlands, Kingdom of the 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact Resubmitted for funding.
Start Year 2011
 
Description Contributions of genetic and environmental factors to muscle density (B1527). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Contributions of genetic and environmental factors to muscle density. 
Organisation School of Clinical Sciences Bristol
Department Musculoskeletal Research Unit
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Costs and Gains to Postponement: How Changes in the Age of Parenthood Influence the Health and Well-being of Children (B2304) 
Organisation London School of Economics and Political Science (University of London)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Cross cohort comparison to explore the causal association between maternal age and perinatal outcomes and later child outcomes (IQ, educational attainment, behaviours, risk taking) - B1163. 
Organisation Federal University of Pelotas (UFPel)
Country Brazil, Federative Republic of 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Cross country variation of Child growth performance by mothers' characteristics and household socio-economic status (B2023). 
Organisation Institute for Health Policy (IHP)
Country Sri Lanka, Democratic Socialist Republic of 
Sector Charity/Non Profit 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Cysteine in Relation to Obesity Genotypes and related Phenotypes in ALSPAC Children (B1142). 
Organisation Medical Sciences Division
Department Department of Pharmacology
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description DGKK variants and fetal growth (B1547). 
Organisation Stanford University
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description DNA methlyation and processing of facial emotion during 7.5% carbon dioxide anxiety challenge (B2202) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution none yet funding dependent
Collaborator Contribution seeking funds for new data collection in subsample of original cohort
Impact n/a
Start Year 2014
 
Description DNA methylation patterns in genes controlling vitamin D metabolism- a lifespan approach (B2230) 
Organisation University of Surrey
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision - funding dependent
Collaborator Contribution seeking funds for secondary analysis
Impact n/a
Start Year 2014
 
Description DXA project (B1483). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution There is a DPhil computer science student from Oxford University on secondment to a commercial company who may be able to automate our novel method for measuring spinal curvature from total body DXA scans. We developed this method as part of the BSRF-funded ALSPAC project B727, and the method has been submitted for publishing and has been presented in abstract form so is in the public domain.
Collaborator Contribution (See above).
Impact N/A (ongoing).
Start Year 2012
 
Description Data mining for robust identification of causal hypotheses. 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Data mining of NMR metabolomics analysis of ALSPAC Child, Mother and Father's samples (B2156) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Deciphering Developmental Disorders: Analysis using quantitative phenotypic information (B2259) 
Organisation University of Edinburgh
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Deductions about human traits and health from ABCC11 genotype (B2079). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Defining endotypes of childhood wheezing to elucidate underlying mechanism and genetic predisposition (B1173). 
Organisation University of Manchester
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Depression at 17: THEME 3 CONTINUITIES AND DISCONTINUITIES - Depression and Fatigue (B2109) 
Organisation Queen Mary University of London (QMUL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2013
 
Description Depression, obesity, dietary patterns and gestational weight gain during pregnancy. 
Organisation King's College London (KCL)
Department Institute of Psychiatry (IoP)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Deriving a measure of maturation status based on percentage of predicted adult stature (B1211) 
Organisation University of Bristol
Department Faculty of Medicine and Dentistry
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact na
Start Year 2011
 
Description Describing habitual levels of physical activity (PA) in older people in terms of impacts and how this relates to bone and other systems. 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact Submitted for grant funding.
Start Year 2012
 
Description Detecting and modelling selection in developmental, lifecourse and ageing-related genes. 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal pending).
Start Year 2012
 
Description Detecting serum metabolite-associated gene sets within ALSPAC. (B2182) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Determining novel causal risk factors for CVD. An original genome-wide Mendelian Randomisation approach (B2073). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Developing a detection and risk prediction for adolescent depressive disorder. 
Organisation Cardiff University School of Medicine
Department Institute of Psychological Medicine & Clinical Neurolosciences
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Developing and applying the SITAR method of growth curve analysis for human growth assessment (B1168). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Developing and disseminating robust methods for handling missing data in epidemiological studies. 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Development of a phenome scan, using ALSPAC data (linked to B173) - B1175. 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Development of an early diagnostic system for psychopathology using video data from the ALSPAC cohort. 
Organisation University of Glasgow
Department College of Medical, Veterinary and Life Sciences
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Development of health risk in childhood and adolescence: Gene-environment interactions and its underlying mechanisms (b2192) 
Organisation University of Amsterdam
Country Netherlands, Kingdom of the 
Sector Academic/University 
PI Contribution data provision - funding dependent
Collaborator Contribution seeking funds for secondary analysis
Impact n/a
Start Year 2014
 
Description Developmental origins of bone phenotypes (b899) 
Organisation Medical Research Council (MRC)
Department MRC Centre for Causal Analyses in Translational Epidemiology
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact Publication
Start Year 2009
 
Description Developmental origins of mood symptoms in children and adolescents; The role of genes, maltreatment, and social process (B1471). 
Organisation Massachusetts General Hospital
Country United States of America 
Sector Hospitals 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2012
 
Description Dietary patterns during pregnancy and gestational weight gain. 
Organisation University of Bristol
Department Avon Longitudinal Study of Parents and Children (ALSPAC)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Dietary patterns in infancy and their associations with growth? (B1246) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution PROVISION OF DATA
Collaborator Contribution INTERPRETATION OF DATA
Impact EARLY STAGES
Start Year 2011
 
Description Dietary patterns in pregnancy and offspring growth outcomes (B2110) 
Organisation University of Leeds
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2013
 
Description Dietary patterns obtained using PCA in partners (B840) 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact Publication
Start Year 2009
 
Description Dietary salt intake in young chidren (B887) 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact Publication
Start Year 2009
 
Description Dissection of ZNF804A association with complex psychiatric disorders. 
Organisation University of Bristol
Department MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Multiple 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Do Psychological Health Issues in Early Childhood Precede Pubertal Maturation? (B2231) 
Organisation University of St Andrews
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Do behavioural, emotional and school problems predict early sexual debut? (B1131) 
Organisation Medical Research Council (MRC)
Department MRC Social & Public Health Sciences Unit
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Do early-life telomere dynamics mediate relationships between early-life environment and later outcomes? (B1125) 
Organisation Newcastle University
Department Institute of Neuroscience
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact Submittted for funding.
Start Year 2011
 
Description Do hypertensive disorders and anaemia in pregnancy increase the risk of respiratory and atopic diseases in childhood? (B1513) 
Organisation Queen Mary University of London (QMUL)
Department Barts and The London School of Medicine and Dentistry
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Do parental, child, and home environment factors mediate the association between socioeconomic status and injury? (B2217) 
Organisation Brown University, USA
Country United States of America 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondar analysis
Impact none yet
Start Year 2014
 
Description Does Mhc-linked mate choice affect child health? (B2296) 
Organisation Newcastle University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision - funding dependent
Collaborator Contribution seeking funds for secondary analysis
Impact n/a
Start Year 2014
 
Description Does TRPA1 modify the effects of prenatal paracetamol and tobacco smoke exposure on childhood respiratory outcomes? (B1467). 
Organisation Queen Mary University of London (QMUL)
Department Barts and The London School of Medicine and Dentistry
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (still ongoing).
Start Year 2012
 
Description Does body dissatisfaction cluster in schools? (b2222) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Does body mass index influence smoking behaviour?  A Mendelian Randomisation study (B2278) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Does early frequency and form of stools predict later bowel and bladder dysfunction and their consequences? (B2220) 
Organisation University of Glasgow
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Does eye colour change between 3 months and 5 years of age? (B2105) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Does high protein intake in infancy associate with rapid growth beyond infancy? 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (propoal in early stages).
Start Year 2012
 
Description Does high protein intake in infancy associate with rapid growth beyond infancy? (B1247) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution PROVISION OF DATE
Collaborator Contribution DATA INTERPRETTED
Impact EARLY STAGES
Start Year 2011
 
Description Does increased bone turnover explain the link between cardiovascular disease and osteoporosis? (B1528) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Does increased bone turnover explain the link between cardiovascular disease and osteoporosis? (b1274) 
Organisation School of Clinical Sciences Bristol
Department Musculoskeletal Research Unit
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Does maternal sensitivity in infancy & actual or feared separation in childhood affect adolescent antisocial behaviour? 
Organisation College of Life and Environmental Sciences
Department Department of Psychology
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Does methylation mediate the effect of physical activity on obesity in childhood? (B2086) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Does repeated school change during childhood increase the risk of psychosislike symptoms (PLIKS) in adolescence? 
Organisation University of Warwick
Department Warwick Medical School
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provison of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Does the way overweight/obese mothers feed their children contribute to the development of childhood obesity? 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Dual trajectories of adolescent smoking and depression (B2059). 
Organisation Northwestern University Chicago
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description EAGLE GWA meta-anaylsis on ADHD (B1465). 
Organisation University of Amsterdam
Department University Medical Center Amsterdam
Country Netherlands, Kingdom of the 
Sector Hospitals 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2012
 
Description EUThyroid (B2184) 
Organisation University of Sussex
Department School of Engineering and Informatics Sussex
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution none yet - funding dependent
Collaborator Contribution seeking funds for new sample assays and secondary analysis
Impact n/a
Start Year 2014
 
Description Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology Consortium (EAGLE) 
Organisation Early Growth Genetics Consortium (EGG)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Private 
PI Contribution Genetic association results and methods have been taken from our work and applied within the EAGLE and EGG frameworks. There has been a primary focus on birthweight, but other health outcomes have been assessed and results developed through the period of collaboration. Collaboration has been longstanding and continues currently.
Collaborator Contribution From these consortia we have been able to obtain the types of sample size required to undertake association testing and applied analysis of complex phenotypic outcomes.
Impact Please see http://egg-consortium.org/ for a list of publications/outputs from the EGG consortium.
Start Year 2013
 
Description Early Life Course Influences on Cognitive and Social Development (B2029). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Early Life Influences on Irreversible Obstructive Airway Disease in Adolescence (B2284) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Early growth and childhood asthma: a meta-analysis. 
Organisation Erasmus University Medical Center (Erasmus MC)
Country Netherlands, Kingdom of the 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal pending).
Start Year 2012
 
Description Early life adversity and cardiometabolic health and cognitive function in mid-life (B2129) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet - just funded
Start Year 2013
 
Description Early life immune and metabolic function and psychotic symptoms in the ALSPAC birth cohort (B1128). 
Organisation School of Clinical Medicine
Department Department of Psychiatry
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Early life predictors of visual and refraction-related phenotypes in early adulthood (B2214) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution new data colelction in original cohort at clinic planned for June 2015 - funding dependent
Collaborator Contribution seeking funds for new data collection
Impact n/a
Start Year 2014
 
Description Early life stress, age of puberty and reproductive behaviour (B2204) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Early life/adolescent influences on STI outcomes (B2282) 
Organisation King's College London (KCL)
Department Institute of Psychiatry (IoP)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision - funding dependent
Collaborator Contribution seeking funds for secondary analysis
Impact n/a
Start Year 2014
 
Description Early pathways to borderline personality symptoms at age 11: the role of temperament and maladaptive parenting (B2777) 
Organisation Utrecht University
Country Netherlands, Kingdom of the 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Early predictors of psychological resilience and mental well-being of children (B1476). 
Organisation London School of Economics and Political Science (University of London)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution N/A - variables not received and so marked as 'Pending'.
Collaborator Contribution N/A - variables not received and so marked as 'Pending'.
Impact N/A - variables not received and so marked as 'Pending'.
Start Year 2012
 
Description Educational attainment and BMI bidrectional assessment of causal relationships using Mendelian randomisation (B1490). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Effect modification of asthma and allergies by GST genotypes in children, living in a mouldy environment. 
Organisation Helmholtz Zentrum München
Department Institute of Epidemiology
Country Germany, Federal Republic of 
Sector Public 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Effect of deviations from expected birth weight on later life cognitive performance and cardiovascular disease (B2252) 
Organisation Harvard University
Country United States of America 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Effects of Early Life Androgens on Gendered Language Use (B2247) 
Organisation Newcastle University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution new data collection in subsample of original cohort - funding dependent
Collaborator Contribution seeking funds for new collection for substudy
Impact n/a
Start Year 2014
 
Description Effects of breastfeeding on children's cognition: the role of DNA methylation. (B2160) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Effects of early pubertal timing on risk for depression and alcohol use in young women (B1208) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Prvision of data
Impact n/a
Start Year 2011
 
Description Effects of maternal alcohol consumption during pregnancy on childhood behaviour in the ALSPAC cohort (B2061). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Effects of maternal vit D status in pregnancy on DNA methylation patterns at birth: association with phenotypes (B1192). 
Organisation Newcastle University
Department Institute of Genetic Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact NB. Currently dormant
Start Year 2011
 
Description Effects of prenatal alcohol exposure on mental health outcomes in adolescence (B1134). 
Organisation College of Arts and Sciences
Department Department of Psychology
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Effects of pubertal timing on children's bullying behaviour and mental health (B2000) 
Organisation University of Warwick
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Effects of vitamin B12 intake during pregnancy on offspring cognitive ability (B2001). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Efficient estimation of causal treatment effects using genotypic data (B1499). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Elucidating phenotypic effects of genetic markers associated with ankylosing spondylitis in adolescents. (B2150) 
Organisation University of Queensland
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Emotional, sexual and physical abuse in early life (B2241) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none
Start Year 2014
 
Description Epigenetic marks at birth, maternal pre-pregnancy obesity & wt gain during pregnancy (B1191). 
Organisation Newcastle University
Department Institute of Genetic Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Epigenetic mechanisms, stress exposure & eating disorders (B1190). 
Organisation Newcastle University
Department Institute of Genetic Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact Resubmitted for funding in February 2012.
Start Year 2011
 
Description Epigenetic variations of miRNAs are associated with hepatocellular carcinoma cancer susceptibility (B2146) 
Organisation Nanjing Medical University
Country China, People's Republic of 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Epigenetics of pre - and post-pubertal leukocytes. 
Organisation Harvard School of Public Health
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Epigenome wide association study of BMI - replication of 278 identified markers using methylation data from ARIES (B2151) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Essential fatty acid status, alcohol and tobacco misuse and genetic variance in candidate pathways. 
Organisation National Institutes of Health (NIH)
Country United States of America 
Sector Public 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Establish overlap between cleft lip/palate genetic associations and normal facial variation genetic associations (B1271) 
Organisation University of Bristol
Department MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Multiple 
PI Contribution provision of data
Collaborator Contribution interpretation of data
Impact early stages
Start Year 2011
 
Description Establishing the link between omega 3 fatty acids and postpartum depression using Mendelian Randomisation (B1516). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Estimating features of trajectories in the diurnal BP of adolescents (B2012). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Evaluating LASER (Learning about Safety by Experiencing Risk) safety education schemes (B2153) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact Papers being prepared
Start Year 2014
 
Description Evaluating therapeutic targets using large-scale populations resources and bioinformatics with collaborators from Sanofi (Tom Richardson) 
Organisation Sanofi
Country Global 
Sector Private 
PI Contribution We have been researching therapeutic targets which are of interest to Sanofi. We have analysed large-scale data and developed an analytical pipeline to conduct in-depth evaluations for future targets of interest.
Collaborator Contribution We have been in regular contact with collaborators to structure the manner in which we are undertaking research. We have also had to face-to-face exchanges to share knowledge and progress in this research area.
Impact Poster presentation at the University of Bristol Industry Day: http://www.bristol.ac.uk/biomedical-sciences/research/industry-event/ Disciplines include: Genetic Epidemiology Statistical Genetics Epigenetics Bioinformatics
Start Year 2016
 
Description Evaluation of a child-parent screening approach to identify people with famillal hypercholesterolaem ia in ALSPAC (B1544). 
Organisation University College London (UCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Evaluation of prenatal and perinatal risk factors for obsessive compulsive disorder in the ALSPAC pre-birth cohort (B2071). 
Organisation University of California
Country United States of America 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Evaluation of shared genetic determinants for chronic inflammatory disorders identifies novel susceptibility variants for eczema (B1159). 
Organisation Helmholtz Association of German Research Centres
Department The Max Delbrück Center for Molecular Medicine (MDC)
Country Germany, Federal Republic of 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact NB. Currently dormant
Start Year 2011
 
Description Evaluation of the prospective effect of chronic pain on social development and behaviour in young people. 
Organisation Bristol Royal Hospital for Children (BRHC)
Department Department of Paediatric Rheumatology
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Hospitals 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stagees).
Start Year 2012
 
Description Examining if polygenic risk scores for ADHD from a clinical sample predict school performance and IQ in ALSPAC (B2033). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Examining the genetic overlap of attention-deficit hyperactivity disorder and autism spectrum disorder traits. 
Organisation Cardiff University School of Medicine
Department Institute of Psychological Medicine & Clinical Neurolosciences
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Examining the mechanisms by which genetic variation contributes to adiposity: how do BMI loci affect dietary intake? 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2011
 
Description Excessive drinking and alcohol related harms in Adulthood: ALSPAC at 24 (B2158) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution we are collecting new data in our original cohort at teh clinic being planned for June 2015
Collaborator Contribution Funds contributed to data collection; will perform data analyses
Impact None yet - funding all recently confirmed
Start Year 2014
 
Description Explaining risk for suicidal behaviour in adolescent offspring of depressed parents (B1492). 
Organisation Cardiff University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Explaining the association between socioeconomic status and cognitive growth in childhood (B1481). 
Organisation Goldsmiths, University of London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Exploration of a possible link between blood selenium and risk of pre-eclampsia and pregancy-induced hypertention (B2228) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Exploration of maternal alcohol consumption, nutrient intake, dietary patterns and infant outcomes. (B2198) 
Organisation Oxford Brookes University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Exploring developmental trajectories of psychosis via growth curve modelling. 
Organisation University of Ulster
Department School of Psychology
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Exploring distinctive facial features and their associations with known candidate genes (B2261) 
Organisation Cardiff University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Exploring relationships between facial shape and bone development (B1210) 
Organisation Cardiff University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data
Collaborator Contribution Provision of data
Impact na
Start Year 2011
 
Description Exploring the association between Attention Deficit/Hyperactivity Disorder (ADHD) and socioeconomic disadvantage (B2206) 
Organisation University of Exeter
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Exploring the development of hallucinations, paranoia, and 'first rank' delusions using latent transition models (B1466). 
Organisation University of Ulster
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (still ongoing).
Start Year 2012
 
Description Exploring the developmental overnutrition hypothesis using an allelic score as an instrumental variable (B2040). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Exploring the fetal insulin hypothesis in ALSPAC (B2112) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact none yet
Start Year 2013
 
Description Exploring the relationship between perinatal depression, disorganised feelings of attachment and child outcomes. 
Organisation University of Bristol
Department Social Science and Community Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Exposome: Noise and air pollution in European cohort studies (ENACT) (B1256) 
Organisation Queen Mary University of London (QMUL)
Department Barts and The London School of Medicine and Dentistry
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution PROVISION OF DATA
Collaborator Contribution INTERPRETATION OF DATA
Impact EARLY STAGES
Start Year 2011
 
Description External validation of an algorithm to estimate overweight risk in childhood from predictors during infancy (B1500). 
Organisation University of Nottingham
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description FLG genotyping in ALSPAC children (B1533). 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Facial dysmorphism and maternal alcohol consumption in the ALSPAC cohort (B1497). 
Organisation University College London (UCL)
Department University College London (UCL), Institute of Child Health
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Factors Associated with Dental Health in a Population Cohort (B2263) 
Organisation University of Bristol
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Factors affecting response rates to ALSPAC questionnaires (B2279) 
Organisation University of the West of England
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution data priovision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2014
 
Description Febrile seizures GWA study. 
Organisation Faculty of Health Sciences
Department Danish Paediatric Asthma Centre
Country Denmark, Kingdom of 
Sector Multiple 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (proposal in early stages).
Start Year 2012
 
Description Fetal Sex and Maternal Prenatal Psychopathology (B2037). 
Organisation Erasmus University Rotterdam (Erasmus Universitair Medisch Centrum EUR)
Country Netherlands, Kingdom of the 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013
 
Description Foetal programming of childhood asthma (B2017). 
Organisation Bradford Institute for Health Research (BIHR)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Provision of data.
Collaborator Contribution Provision of data.
Impact N/A (ongoing).
Start Year 2013