Epidemiological and statistical research on health problems of developing countries: MRC Tropical Epidemiology Group

Lead Research Organisation: London Sch of Hygiene and Trop Medicine
Department Name: Epidemiology and Population Health

Abstract

The past decade has seen significant progress in health in developing countries as well as setbacks and new challenges. Gains in health in many low-income countries have been reversed due to the global epidemic of HIV/AIDS and steep increases in tuberculosis (TB). Malaria remains a major killer of children in Africa despite declines in some countries. There is an urgent need to find effective means of controlling these major diseases.

The main aim of the MRC Tropical Epidemiology Group, based at the London School of Hygiene & Tropical Medicine, is to conduct research on interventions against diseases of major public health importance in Africa and other parts of the developing world. We collaborate with scientific groups overseas, including MRC Units in The Gambia and Uganda, assisting with the planning and analysis of research studies. These studies are designed to improve our understanding of risk factors for these diseases, and to evaluate the impact of different control measures. During the next five years, our main focus will continue to be on HIV, TB and malaria, and we will expand our work on non-communicable diseases, which are rapidly increasing in importance in developing countries.

There have been major advances in HIV prevention in recent years, especially around the potential for antiretroviral drugs to be used to prevent HIV transmission. We will work on further studies to evaluate methods of preventing and treating HIV infection, and to scale up interventions, such as voluntary medical male circumcision, that are known to reduce the risk of HIV infection. We will also expand work on integration of care for HIV-patients with treatment of other chronic diseases such as heart disease and diabetes. Research on human papillomavirus (HPV), which can cause cervical cancer, will include studies of how best to deliver HPV vaccination to girls and young women in sub-Saharan Africa.

Our TB research will focus on large-scale trials to assess how best to treat patients co-infected with both TB and HIV, and to improve the ways in which care for TB and HIV are integrated. A new diagnostic test for TB which has the potential to revolutionize TB diagnosis has recently been developed (Xpert MTB/RIF). We will also evaluate the impact and cost-effectiveness of this test for routine TB diagnosis in South Africa.

Substantial reductions in malaria have been reported recently, but much of this progress has been in countries with low levels of malaria, and malaria rates remain unacceptably high in many African countries. In the Sahel region, most of the malaria mortality and morbidity occurs during the short rainy season. We have been closely involved in research showing that giving effective malaria chemoprevention during this period prevents illness and death from malaria in children. We will continue our research in this area, including assessing the impact of this treatment strategy on malaria cases and deaths when delivered through routine health services. We will also continue research on promising malaria vaccines, and to evaluate new methods to control the mosquitoes that transmit malaria.

While the major infectious diseases continue to play a major role, especially in sub-Saharan Africa, there is increasing recognition of the impact of non-communicable diseases. The prevalence of conditions such as cardiovascular disease, diabetes and mental illness is increasing, especially in growing urban centres in developing countries, and will require innovative approaches to prevention and control.

There are few experienced medical statisticians in research institutions and universities in Africa, and an important aspect of our work is to support a fellowship scheme, which provides a two-year training programme for statisticians. In addition, we teach research methods at workshops at collaborating sites and provide informal mentoring and supervision to statisticians and epidemiologists we work with.

Technical Summary

We will conduct epidemiological research on HIV, TB, malaria and other diseases of public health importance in developing countries with an emphasis on randomised intervention trials.

In HIV, we will conduct the first trial of the impact of a test-and-treat intervention on HIV incidence in Africa, implementation research on scale-up of male circumcision, and RCTs to reduce early mortality among patients with low CD4 counts and to evaluate different treatment strategies for cryptococcal meningitis.

In TB, we will complete a trial of a four-month pulmonary TB treatment regimen. We will extend our research on treatment strategies for TB and HIV co-infection, including trials to compare 3 treatment strategies in ARV-naïve TB/HIV patients, a CRT to assess the effect of a point-of-care TB test-and-treat algorithm on early mortality in HIV-infected patients accessing ART; and a CRT of the impact of TB diagnosis by Xpert MTB/RIF on mortality and time-to-initiation of treatment.

Malaria research will build on previous work on Seasonal Malaria Chemoprevention (SMC), to evaluate effectiveness of delivery through routine health services, to monitor for adverse effects and to determine the effectiveness of adding SMC to existing control strategies for malaria. We will continue to evaluate multi-component malaria control on Bioko Island, and will develop new collaborations to assess the role of the RTS,S vaccine if licensed.

We will continue trials on lay-health worker interventions to treat common mental disorders, on the beneficial and adverse effects of helminths and antihelmintics on other conditions and of the effectiveness of pneumococcal vaccines. Methodological work will include spatial analysis of spill-over effects in CRTs, and evaluation and prediction of vaccine impact. Finally, we will continue to build research capacity in Africa, including development of the MRC-supported Mwanza Intervention Trials Unit and our programme of TEG training fellowships.

Planned Impact

As highlighted in the Millennium Development Goals, there is a strong synergy between ill-health and poverty. Our research focuses on diseases that are major causes of morbidity and mortality in resource-poor countries. These diseases have a substantial impact on the socio-economic development of many of these countries. By reducing the rates of important causes of ill health, such measures have the potential to alleviate poverty as well as improving life expectancy. We are expanding our focus on implementation research of proven interventions, and health systems research, which can improve the effectiveness and efficiency of health care delivery and ensure that resources reach the right people.

Many of the diseases we focus on typically affect the poorest in resource-poor countries, and those marginalised from society. We have a strong focus on community-based interventions (for example, in the PopART and TB trials which incorporate home-based HIV and TB testing) which help to overcome barriers to health service access and minimize stigma and discrimination. We also focus on scaling-up interventions which have been proven to be effective - for example male circumcision for HIV prevention, and seasonal malaria chemoprevention in areas with highly seasonal malaria transmission. This implementation research will help ensure access to effective prevention technologies for those who need it, regardless of socio-economic status. Our expanding health systems research (for example on integrating HIV and non-communicable disease treatment and care) will also increase the population-level impact of known effective treatment.

Our research is locally disseminated to study populations, and to regional and national stakeholders and policymakers, as appropriate. This includes providing information to enable policy-makers to make decisions about cost-effective strategies of roll-out (for example, for HPV vaccination or male circumcision scale-up), or access to new technology (such as TB diagnostics including Xpert MTB/RIF). We also play an active role in influencing global health policy and directions for future research, through membership of international technical and policy advisory committees including chairing the WHO Joint Technical Expert Group on Malaria Vaccines in Pivotal Phase 3 Trials & Beyond, the WHO Malaria Policy Advisory Committee Evidence Review Group on Malaria Burden Estimation and the EDCTP Partnership Board; and membership of several other Committees, as outlined in the Case for Support.

Organisations


Publications


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Ae-Ngibise KA (2015) Prevalence and risk factors for Active Convulsive Epilepsy in Kintampo, Ghana. in The Pan African medical journal

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Afolabi MO (2015) A multimedia consent tool for research participants in the Gambia: a randomized controlled trial. in Bulletin of the World Health Organization

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Agweyu A (2015) Oral amoxicillin versus benzyl penicillin for severe pneumonia among kenyan children: a pragmatic randomized controlled noninferiority trial. in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Agyepong I (2015) Making sense of health estimates in The Lancet



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Albert S (2015) Medical pluralism among indigenous peoples in northeast India - implications for health policy. in Tropical medicine & international health : TM & IH

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Alexander N (2013) Defining ELISpot cut-offs from unreplicated test and control wells. in Journal of immunological methods

 
Description Combining Indoor Residual Spraying and Insecticidal Long Lasting Nets: presentation to WHO Malaria Advisory Committee
Geographic Reach Africa 
Policy Influence Type Participation in a advisory committee
URL http://www.who.int/malaria/publications/atoz/who-guidance-combining-irs_llins-mar2014.pdf
 
Guideline Title Ebola Virus Disease (EVD) Information for Clinicians in U.S. Healthcare Settings
Description Ebola Clinical Management
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
URL http://www.cdc.gov/vhf/ebola/healthcare-us/preparing/clinicians.html
 
Description Membership of WHO Vector Control Advisory Group
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
URL http://www.who.int/neglected_diseases/vector_ecology/VCAG/en
 
Description The Friendship Bench
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact A recently carried out randomized control trial showed that the Friendship Bench can deliver a successful, culturally acceptable and reliable treatment program for depression on a primary care level (Chibanda, D, Bowers, T, Verhey, R, Rusakaniko, S, Abas, M, Weiss, H A, Araya, R. The Friendship Bench programme: a cluster randomised controlled trial of a brief psychological intervention for common mental disorders delivered by lay health workers in Zimbabwe. International journal of mental health systems 2015a; 9, 21). It also addresses the stigma of mental illness in society, and the training of lay workers to deliver problem solving therapy helps address the deficit of mental health specialists in Zimbabwe.
URL http://www.friendshipbenchzimbabwe.org
 
Description Adolescent 360 Evaluation
Amount $479,341 (USD)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States of America
Start 04/2016 
End 08/2020
 
Description Africa Centre Collaborations Fund
Amount £9,000 (GBP)
Funding ID ISSF/ADDE814710 
Organisation The Wellcome Trust Ltd 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 09/2014 
End 06/2015
 
Description AmBisone
Amount £10,677 (GBP)
Organisation Médecins Sans Frontières (MSF) 
Sector Charity/Non Profit
Country France, French Republic
Start 09/2016 
End 03/2018
 
Description Aurum Institute - Highly TB exposed, persistently uninfected South African gold miners: HETU study
Amount $971,347 (USD)
Organisation Aurum Institute 
Sector Public
Country South Africa, Republic of
Start 11/2014 
End 12/2016
 
Description BMFG - China Gates
Amount $418,871 (USD)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States of America
Start 11/2014 
End 09/2019
 
Description CHIDO Trial
Amount $26,929 (USD)
Organisation Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) 
Sector Charity/Non Profit
Country Zimbabwe, Republic of
Start 01/2016 
End 01/2017
 
Description DIAMA
Amount € 175,446 (EUR)
Funding ID DRIA2014-326 
Organisation European Developing Countries Clinical Trials Platform (EDCTP) 
Sector Public
Country Netherlands, Kingdom of the
Start 06/2016 
End 05/2021
 
Description EU FP7 Theme: AfriCoLeish
Amount € 3,000,000 (EUR)
Organisation European Commission (EC) 
Sector Public
Country European Union (EU)
Start 01/2013 
End 12/2016
 
Description Investigation of HEV transmission dynamics and epidemic evolution to improve outbreak control efforts among emergency affected populations
Amount $11,687 (USD)
Organisation CDC Foundation 
Sector Public
Country Georgia
Start 12/2015 
End 12/2016
 
Description Joint Global Health Trials
Amount £2,986,615 (GBP)
Organisation MRC and the Department for International Development (DFID) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 03/2016 
End 02/2021
 
Description Joint Global Health Trials 2013
Amount £1,856,394 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2014 
End 09/2017
 
Description Joint Global Health Trials 2013
Amount £836,321 (GBP)
Funding ID MR/L00433X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 12/2013 
End 05/2016
 
Description Joint Global Health Trials Development Grant
Amount £200,000 (GBP)
Funding ID MR/P020283/1 
Organisation MRC-UK 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2017 
End 10/2018
 
Description MSF - TB PRACTECAL
Amount £167,820 (GBP)
Organisation Médecins Sans Frontières (MSF) 
Sector Charity/Non Profit
Country France, French Republic
Start 10/2013 
End 12/2017
 
Description Master's Fellowship in Epidemiology and Medical Statistics
Amount £119,985 (GBP)
Organisation European Developing Countries Clinical Trials Platform (EDCTP) 
Sector Public
Country Netherlands, Kingdom of the
Start 09/2014 
End 09/2016
 
Description Master's Fellowship in Epidemiology and Medical Statistics
Amount £116,925 (GBP)
Organisation European Developing Countries Clinical Trials Platform (EDCTP) 
Sector Public
Country Netherlands, Kingdom of the
Start 09/2014 
End 09/2016
 
Description Master's Fellowship in Epidemiology and Medical Statistics
Amount £119,985 (GBP)
Organisation Sixth Framework Programme (FP6) 
Department European and Developing Countries Clinical Trials Partnership (EDCTP)
Sector Public
Country European Union (EU)
Start 10/2014 
End 09/2016
 
Description New Investigator Research Grant - Suzanna Francis
Amount £917,566 (GBP)
Funding ID MR/N023692/1 
Organisation MRC-UK 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 07/2016 
End 06/2019
 
Description Newton Household Screening for TB
Amount £57,297 (GBP)
Organisation Government of South Africa 
Department Medical Research Council of South Africa (MRC)
Sector Public
Country South Africa, Republic of
Start 05/2016 
End 12/2018
 
Description Public Health Intervention Development Scheme
Amount £150,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2014 
End 07/2015
 
Description Public Health Intervention Development Scheme
Amount £143,663 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 02/2014 
End 10/2014
 
Description RAFAScreen
Amount € 39,856 (EUR)
Organisation National Tuberculosis Programme of Benin 
Sector Public
Country Benin, Republic of
Start 08/2015 
End 07/2016
 
Description RIFASHORT (Joint funded initiatives)
Amount £92,651 (GBP)
Funding ID MR/M006127/1 
Organisation MRC-UK 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 06/2016 
End 12/2019
 
Description Research & Innovation Action
Amount € 41,385 (EUR)
Funding ID 666094 
Organisation European Commission (EC) 
Sector Public
Country European Union (EU)
Start 11/2014 
End 10/2015
 
Description TE NTD Research for Sightsavers
Amount £91,236 (GBP)
Organisation Sightsavers 
Sector Charity/Non Profit
Country Global
Start 12/2014 
End 12/2015
 
Description Technical Support for Insecticide Resistance in India
Amount $63,887 (USD)
Funding ID 39312 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States of America
Start 12/2015 
End 12/2016
 
Description Tuberculosis: Innovative Delivery Approaches
Amount $203,358 (USD)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States of America
Start 11/2014 
End 10/2016
 
Description UNITAID Strategic Objective 4: Treatment of Malaria (Round 2)
Amount $67,400,000 (USD)
Organisation World Health Organization (WHO) 
Department UNITAID
Sector Public
Country Switzerland, Swiss Confederation
Start 01/2015 
End 12/2018
 
Description UNITAID Strategic Objective 6: Preventatives for HIV/Aids, TB and Malaria
Amount $7,480,000 (USD)
Organisation World Health Organization (WHO) 
Department UNITAID
Sector Public
Country Switzerland, Swiss Confederation
Start 01/2015 
End 12/2018
 
Description UNITAID/PSI STAR Project
Amount $244,169 (USD)
Organisation World Health Organization (WHO) 
Department UNITAID
Sector Public
Country Switzerland, Swiss Confederation
Start 10/2015 
End 10/2017
 
Description Zvandiri Project
Amount £43,147 (GBP)
Organisation Viiv Healthcare 
Sector Private
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2016 
End 12/2016
 
Description 3HPstudy 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Study design and analysis
Collaborator Contribution Study design, co-ordination, economic modelling, trial recruitment
Impact Multi-disciplinary: public health, health economics, statistics, trial design
Start Year 2015
 
Description 3HPstudy 
Organisation Johns Hopkins University
Country United States of America 
Sector Academic/University 
PI Contribution Study design and analysis
Collaborator Contribution Study design, co-ordination, economic modelling, trial recruitment
Impact Multi-disciplinary: public health, health economics, statistics, trial design
Start Year 2015
 
Description AMARI 
Organisation Addis Ababa University
Country Ethiopia, Federal Democratic Republic of 
Sector Academic/University 
PI Contribution Steering committee member
Collaborator Contribution Study co-ordination
Impact PhD and post-doctoral researchers enrolled
Start Year 2015
 
Description AMARI 
Organisation University of Cape Town
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Steering committee member
Collaborator Contribution Study co-ordination
Impact PhD and post-doctoral researchers enrolled
Start Year 2015
 
Description AMARI 
Organisation University of Malawi
Country Malawi, Republic of 
Sector Academic/University 
PI Contribution Steering committee member
Collaborator Contribution Study co-ordination
Impact PhD and post-doctoral researchers enrolled
Start Year 2015
 
Description AMARI 
Organisation University of Zimbabwe
Country Zimbabwe, Republic of 
Sector Academic/University 
PI Contribution Steering committee member
Collaborator Contribution Study co-ordination
Impact PhD and post-doctoral researchers enrolled
Start Year 2015
 
Description AfricoLeisch Consortium 
Organisation Drugs for Neglected Diseases initiative (DNDi)
Country Switzerland, Swiss Confederation 
Sector Private 
PI Contribution Statistical lead and data management oversight
Collaborator Contribution Intellectual input and expertise; access to data; capacity building; research dissemination
Impact Treatment trials in progress
Start Year 2013
 
Description AfricoLeisch Consortium 
Organisation European Commission (EC)
Country European Union (EU) 
Sector Public 
PI Contribution Statistical lead and data management oversight
Collaborator Contribution Intellectual input and expertise; access to data; capacity building; research dissemination
Impact Treatment trials in progress
Start Year 2013
 
Description AfricoLeisch Consortium 
Organisation Institute of Tropical Medicine Antwerp
Country Belgium, Kingdom of 
Sector Academic/University 
PI Contribution Statistical lead and data management oversight
Collaborator Contribution Intellectual input and expertise; access to data; capacity building; research dissemination
Impact Treatment trials in progress
Start Year 2013
 
Description AfricoLeisch Consortium 
Organisation Médecins Sans Frontières (MSF)
Country France, French Republic 
Sector Charity/Non Profit 
PI Contribution Statistical lead and data management oversight
Collaborator Contribution Intellectual input and expertise; access to data; capacity building; research dissemination
Impact Treatment trials in progress
Start Year 2013
 
Description AfricoLeisch Consortium 
Organisation University of Gondar
Country Ethiopia, Federal Democratic Republic of 
Sector Academic/University 
PI Contribution Statistical lead and data management oversight
Collaborator Contribution Intellectual input and expertise; access to data; capacity building; research dissemination
Impact Treatment trials in progress
Start Year 2013
 
Description AfricoLeisch Consortium 
Organisation University of Khartoum
Country Sudan, Republic of 
Sector Academic/University 
PI Contribution Statistical lead and data management oversight
Collaborator Contribution Intellectual input and expertise; access to data; capacity building; research dissemination
Impact Treatment trials in progress
Start Year 2013
 
Description Assessing the impact of the introduction of pneumococcal conjugate vaccine into the childhood vaccine programme 
Organisation The Wellcome Trust Ltd
Department KEMRI-Wellcome Trust Research Programme
Country Kenya, Republic of 
Sector Multiple 
PI Contribution Providing statistical support
Collaborator Contribution Principal investiagors and data collection
Impact Paper on efficacy of different pneumococcal conjugate vaccine schedules against pneumonia, hospitalisation, and mortality in the Gambia published in Vaccine (2014)
Start Year 2014
 
Description Associations between latent TB infection in mothers and infant immune response to immunisations 
Organisation University of Malawi
Country Malawi, Republic of 
Sector Academic/University 
PI Contribution Statistical contribution to trial design. We will be supervising data analysis going forward.
Collaborator Contribution Significant intellectual input and mutual exchange of ideas
Impact None yet.
Start Year 2014
 
Description CHIDO trial 
Organisation Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe)
Country Zimbabwe, Republic of 
Sector Charity/Non Profit 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health
Start Year 2015
 
Description CRT of an intensified TB/HIV prevention intervention in Malawi 
Organisation The Wellcome Trust Ltd
Department Malawi-Liverpool Wellcome Trust Clinical Research Programme
Country Malawi, Republic of 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Intervention evaluation period is complete and final survey (HIV prevalence) is underway. Trial analysis is ongoing. Paper on a sub-trial of home-based versus community-based initiation of HIV care published in JAMA (2014).
Start Year 2010
 
Description CRT of intensive versus standard anthelminthic treatment and effects on allergy-related health outcomes 
Organisation Medical Research Council (MRC)
Department Medical Research Council (MRC), MRC/UVRI Unit, Uganda
Country Uganda, Republic of 
Sector Public 
PI Contribution Contributed to trial design. Currently leading statistical analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol paper submitted to Trials, baseline findings presented at the European Academy of Allergy and Clinical Immunology (EAACI) conference in June 2014. Intervention is currently ongoing.
Start Year 2011
 
Description Capacity Development 
Organisation Xinjiang Medical University
Department Department of Epidemiology and Biostatistics
Country China, People's Republic of 
Sector Academic/University 
PI Contribution Training in Epidemiology
Collaborator Contribution Providing research data
Impact Training programme established between Xinjiang and LSHTM
Start Year 2013
 
Description Clinical Trial: HIV combination prevention (PopArt) 
Organisation Imperial College London (ICL)
Department Imperial College of Science Technology and Medicine (ICSTM)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration
Collaborator Contribution Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College.
Impact Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions
Start Year 2011
 
Description Clinical Trial: HIV combination prevention (PopArt) 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Department Zambia AIDS Related Tuberculosis (ZAMBART)
Country Zambia, Republic of 
Sector Academic/University 
PI Contribution Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration
Collaborator Contribution Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College.
Impact Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions
Start Year 2011
 
Description Clinical Trial: HIV combination prevention (PopArt) 
Organisation National Institutes of Health (NIH)
Department HIV Prevention Trials Network HPTN
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration
Collaborator Contribution Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College.
Impact Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions
Start Year 2011
 
Description Clinical Trial: HIV combination prevention (PopArt) 
Organisation University of Stellenbosch
Department Desmond Tutu TB Centre
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration
Collaborator Contribution Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College.
Impact Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions
Start Year 2011
 
Description Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators
Start Year 2012
 
Description Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART 
Organisation Foundation for Professional Development
Country South Africa, Republic of 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators
Start Year 2012
 
Description Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART 
Organisation Johns Hopkins University
Country United States of America 
Sector Academic/University 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators
Start Year 2012
 
Description Clinical trial: Impact of helminths on the response to immunisation and on incidence of infection and disease in childhood 
Organisation Entebbe District Hospital
Country Uganda, Republic of 
Sector Hospitals 
PI Contribution Designed and supported randomised trial evaluating 3 interventions at 2 stages.
Collaborator Contribution Trial leadership; Access to study cohort
Impact Trial found that anthelminthic treatment during pregnancy increased incidence of eczema in childhood, and that quarterly anthelminthic treatment during early childhood decreased the incidence of malaria. Apart from this, there were no other effects of anthelminthic treatment during pregnancy and childhood on responses to immunisations, incidence of infectious diseases, growth or anaemia. Main trial results have been published in the Lancet and in PLoS ONE. Children are now being follow-up to 10 years old.
Start Year 2006
 
Description Clinical trial: Impact of helminths on the response to immunisation and on incidence of infection and disease in childhood 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Designed and supported randomised trial evaluating 3 interventions at 2 stages.
Collaborator Contribution Trial leadership; Access to study cohort
Impact Trial found that anthelminthic treatment during pregnancy increased incidence of eczema in childhood, and that quarterly anthelminthic treatment during early childhood decreased the incidence of malaria. Apart from this, there were no other effects of anthelminthic treatment during pregnancy and childhood on responses to immunisations, incidence of infectious diseases, growth or anaemia. Main trial results have been published in the Lancet and in PLoS ONE. Children are now being follow-up to 10 years old.
Start Year 2006
 
Description Clinical trial: Implementation and evaluation of an optimized model for scaling up TB/HIV integration at primary care clinics in Ekurhuleni north sub-district, South Africa 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Protocol and CRFs drafted; trial completed and data currently being analysed. Paper published on trial design (Contemporary Clinical Trials 2014)
Start Year 2011
 
Description Clinical trial: Microbicides Development Programme 
Organisation MRC/DFID Microbicides Development Programme (MDP)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution PI for Mwanza field site; statistical input to trial
Collaborator Contribution Collaborative involvement in Phase III trial of Pro2000 vaginal microbicide
Impact Successful completion and publication of MDP301 Phase III trial; further publications in progress; capacity building in partner sites in Africa; development of proposal for MDP302 trial
 
Description Clinical trial: Treatment and prevention strategies for HIV-associated cryptococcal meningitis 
Organisation St George's University of London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Trial design and data analysis
Collaborator Contribution Significant intellectual input and mutual exchange of ideas
Impact Findings published in several high impact journals. A second trial is now underway to determine the most effective and sustainable regimens for patients presenting with cryptococcal meningitis in resource-poor settings
Start Year 2006
 
Description Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress.
Start Year 2011
 
Description Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study 
Organisation National Health Laboratory Service (NHLS)
Country South Africa, Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress.
Start Year 2011
 
Description Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study 
Organisation University of Cape Town
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress.
Start Year 2011
 
Description Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress.
Start Year 2011
 
Description DIVIDS study and follow-ups 
Organisation University of Delhi
Department Institute of Home Economics
Country India, Republic of 
Sector Academic/University 
PI Contribution Analysis of RCT of vitamin D supplementation to low birth weight term infants. Analysis of follow-up data from 4-5 year olds
Collaborator Contribution Co-ordination of the field work
Impact Analysis of main trial result in BMJ. Follow-up data was published in Int J Epi and BMJ Open. Multi-disciplinary - nutrition.
Start Year 2010
 
Description DREAMS evaluation 
Organisation African Population and Health Research Center (APHRC)
Country Kenya, Republic of 
Sector Academic/University 
PI Contribution co-Principal investigator
Collaborator Contribution Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation
Impact Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science
Start Year 2016
 
Description DREAMS evaluation 
Organisation Armauer Hansen Research Institute (AHRI)
Country Ethiopia, Federal Democratic Republic of 
Sector Charity/Non Profit 
PI Contribution co-Principal investigator
Collaborator Contribution Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation
Impact Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science
Start Year 2016
 
Description DREAMS evaluation 
Organisation Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe)
Country Zimbabwe, Republic of 
Sector Charity/Non Profit 
PI Contribution co-Principal investigator
Collaborator Contribution Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation
Impact Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science
Start Year 2016
 
Description DREAMS evaluation 
Organisation Kenyan Institute for Medical Research (KEMRI)
Country Kenya, Republic of 
Sector Public 
PI Contribution co-Principal investigator
Collaborator Contribution Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation
Impact Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science
Start Year 2016
 
Description DREAMS evaluation 
Organisation United States President's Emergency Plan for AIDS Relief (PEPFAR)
Country United States of America 
Sector Public 
PI Contribution co-Principal investigator
Collaborator Contribution Co-design of impact evaluation design, new research questionnaires, lead responsibility for field implementation
Impact Multi-disciplinary: Epidemiology, Demography, Public Health, Social Science
Start Year 2016
 
Description Dengue Index 
Organisation Khon Kaen University
Country Thailand, Kingdom of 
Sector Academic/University 
PI Contribution Design and analysis of case-control study and cluster-randomized trial
Collaborator Contribution Carrying out clinical and entomological investigations in clinics and homes
Impact Multi-disciplinary: Entomology, public health
Start Year 2016
 
Description Dengue Index 
Organisation Norwegian University of Life Sciences (NMBU)
Country Norway, Kingdom of 
Sector Academic/University 
PI Contribution Design and analysis of case-control study and cluster-randomized trial
Collaborator Contribution Carrying out clinical and entomological investigations in clinics and homes
Impact Multi-disciplinary: Entomology, public health
Start Year 2016
 
Description Design and analysis of clinical trials for the treatment of Visceral Leishmaniasis 
Organisation Drugs for Neglected Diseases initiative (DNDi)
Country Switzerland, Swiss Confederation 
Sector Private 
PI Contribution Contributed to design and analysis of clinical trials, continued capacity building in data management, study design and analysis methods, preparation of successful grant applications, project management
Collaborator Contribution Sponsorship of clinical trials, intellectual input, project management, leadership
Impact Trials ongoing. Demonstration of ability to conduct rigorous research in the context of a public health emergency and engage affected communities in a volatile stigmatised environment. Multi-disciplinary - Statistics, clinical, public health.
Start Year 2013
 
Description Design and analysis of clinical trials for the treatment of Visceral Leishmaniasis 
Organisation Institute of Tropical Medicine Antwerp
Country Belgium, Kingdom of 
Sector Academic/University 
PI Contribution Contributed to design and analysis of clinical trials, continued capacity building in data management, study design and analysis methods, preparation of successful grant applications, project management
Collaborator Contribution Sponsorship of clinical trials, intellectual input, project management, leadership
Impact Trials ongoing. Demonstration of ability to conduct rigorous research in the context of a public health emergency and engage affected communities in a volatile stigmatised environment. Multi-disciplinary - Statistics, clinical, public health.
Start Year 2013
 
Description Design and analysis of clinical trials for the treatment of Visceral Leishmaniasis 
Organisation Leishmaniasis East Africa Platform (LEAP)
Country Sudan, Republic of 
Sector Public 
PI Contribution Contributed to design and analysis of clinical trials, continued capacity building in data management, study design and analysis methods, preparation of successful grant applications, project management
Collaborator Contribution Sponsorship of clinical trials, intellectual input, project management, leadership
Impact Trials ongoing. Demonstration of ability to conduct rigorous research in the context of a public health emergency and engage affected communities in a volatile stigmatised environment. Multi-disciplinary - Statistics, clinical, public health.
Start Year 2013
 
Description EIP trial 
Organisation Medical Research Council (MRC)
Department MRC/UVRI Unit, Uganda
Country Uganda, Republic of 
Sector Public 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary - Epidemiology, public health
Start Year 2017
 
Description Eave Tubes 
Organisation Cote D'Ivoire's National Institute of Public Health
Country Cote d'Ivoire, Republic of 
Sector Public 
PI Contribution Project statistician/epidemiologist- co-design of study and analysis; coordination with sample collection and fieldwork
Collaborator Contribution co-design; development of novel vector control product; field activities; entomological activities; lab analysis of samples
Impact Multi-disciplinary: epidemiology, public health, social science, entomology
Start Year 2016
 
Description Eave Tubes 
Organisation In2Care BV
Country Netherlands, Kingdom of the 
Sector Private 
PI Contribution Project statistician/epidemiologist- co-design of study and analysis; coordination with sample collection and fieldwork
Collaborator Contribution co-design; development of novel vector control product; field activities; entomological activities; lab analysis of samples
Impact Multi-disciplinary: epidemiology, public health, social science, entomology
Start Year 2016
 
Description Eave Tubes 
Organisation Penn State University
Country United States of America 
Sector Academic/University 
PI Contribution Project statistician/epidemiologist- co-design of study and analysis; coordination with sample collection and fieldwork
Collaborator Contribution co-design; development of novel vector control product; field activities; entomological activities; lab analysis of samples
Impact Multi-disciplinary: epidemiology, public health, social science, entomology
Start Year 2016
 
Description Eliminate Dengue Program 
Organisation Monash University
Department Eliminate Dengue Program; Monash University
Country Australia, Commonwealth of 
Sector Academic/University 
PI Contribution Design of cluster randomised trial to evaluate effectiveness of large scale Wolbachia deployments on dengue transmission
Collaborator Contribution Facilitation and hosting of three workshops to design and plan trials in Indonesia and Vietnam
Impact Study protocol and draft manuscript on trial design. Multi-disciplinary - Epidemiology, Entomology, Infectious Disease Control, Statistics, Modelling.
Start Year 2015
 
Description Elimination Eight Partnerships 
Organisation Elimination Eight
Country Namibia, Republic of 
Sector Private 
PI Contribution Technical advice and leadership for malaria elimination in 8 SADC countries
Collaborator Contribution Co-ordination of regional malaria elimnation strategies
Impact Multi-disciplinary: Epidemiology, Public Health
Start Year 2016
 
Description Epidemiology of alcohol use and alcohol use disorders among young people in northern Tanzania 
Organisation NIMR Dar Es Salaam
Country Tanzania, United Republic of 
Sector Public 
PI Contribution PhD supervision (study design and supervision of analysis)
Collaborator Contribution Study design, co-ordination and analysis
Impact 4 papers published - included in publication section on researchfish submission. Multi-disciplinary: epidemiology, public health
Start Year 2011
 
Description Epidemiology of microcephaly and Zika in Pernambuco, Brasil 
Organisation Oswaldo Cruz Foundation (Fiocruz)
Country Brazil, Federative Republic of 
Sector Public 
PI Contribution Space/time analysis of data on incidence of microcephaly; estimation of incidence of Zika,
Collaborator Contribution Multiple population and hospital-based studies on microcephaly and Zika.
Impact None as yet.
Start Year 2016
 
Description Evaluation of an mHealth app for Ebola contact tracing 
Organisation Innovations for Poverty Action (IPA)
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Design & analysis of a smartphone app to improve contact tracing and monitoring during the 2015 Ebola outbreak in Sierra Leone
Collaborator Contribution Development of the app
Impact Final analysis is ongoing. Multi disciplinary - Epidemiology, social science, technology
Start Year 2015
 
Description Evaluation of convalescent Plasma for Ebola Virus Disease in Sierra Leone 
Organisation Institute of Tropical Medicine Antwerp
Country Belgium, Kingdom of 
Sector Academic/University 
PI Contribution Contributing to design and analysis of clinical trials, preparation of successful grant applications, project management
Collaborator Contribution Sponsorship of clinical trials, intellectual input, project management, leadership
Impact Publication of trial findings in New England Journal of Medicine. Multi-disciplinary - Statistics, clinical, public health.
Start Year 2014
 
Description Evaluation of convalescent Plasma for Ebola Virus Disease in Sierra Leone 
Organisation University of Liverpool
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Contributing to design and analysis of clinical trials, preparation of successful grant applications, project management
Collaborator Contribution Sponsorship of clinical trials, intellectual input, project management, leadership
Impact Publication of trial findings in New England Journal of Medicine. Multi-disciplinary - Statistics, clinical, public health.
Start Year 2014
 
Description Friendship Bench 
Organisation University of Zimbabwe
Country Zimbabwe, Republic of 
Sector Academic/University 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health 3 papers published, details in publications section of researchfish submission Outcome - Scale-up of the Friendship Bench in Zimbabwe
Start Year 2013
 
Description GMZ2 Consortium 
Organisation Centre de Recherches Médicales de Lambaréné
Country Gabon, Gabonese Republic 
Sector Charity/Non Profit 
PI Contribution Design and analysis of the GMZ2 malaria vaccine trial
Collaborator Contribution Co-ordination of the field trial
Impact Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise.
Start Year 2008
 
Description GMZ2 Consortium 
Organisation Makerere University College of Health Sciences
Country Uganda, Republic of 
Sector Academic/University 
PI Contribution Design and analysis of the GMZ2 malaria vaccine trial
Collaborator Contribution Co-ordination of the field trial
Impact Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise.
Start Year 2008
 
Description GMZ2 Consortium 
Organisation Medical Research Council (MRC)
Department Medical Research Council (MRC), MRC Laboratories, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Design and analysis of the GMZ2 malaria vaccine trial
Collaborator Contribution Co-ordination of the field trial
Impact Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise.
Start Year 2008
 
Description GMZ2 Consortium 
Organisation Navrongo Health Research Centre (NHRC)
Country Ghana, Republic of 
Sector Public 
PI Contribution Design and analysis of the GMZ2 malaria vaccine trial
Collaborator Contribution Co-ordination of the field trial
Impact Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise.
Start Year 2008
 
Description GMZ2 Consortium 
Organisation Statens Serum Institut (SSI)
Country Denmark, Kingdom of 
Sector Public 
PI Contribution Design and analysis of the GMZ2 malaria vaccine trial
Collaborator Contribution Co-ordination of the field trial
Impact Final efficacy analysis is ongoing. This is a multi centre phase 2b vaccine trial so involves clinical, epidemiological, statistical and laboratory (immunology) expertise.
Start Year 2008
 
Description Global mental health trials 
Organisation Sangath
Country India, Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical and epidemiological collaboration
Collaborator Contribution Leadership and all aspects of the trials
Impact Evidence to support the use of lay health workers in delivering psychosocial interventions in primary care clinics. Multi disciplinary - Epidemiology, statistics, clinical, public health
 
Description Good Health for Women Project 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Analysis of a long-term cohort of women at high risk of HIV
Collaborator Contribution Study co-ordination
Impact Multi-disciplinary: epidemiology, social science
Start Year 2016
 
Description HDTstudy 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Study design and supervising analysis
Collaborator Contribution Study design, co-ordination, trial recruitment
Impact Multi-disciplinary: statistics, trial design, immunology
Start Year 2016
 
Description HIV Self-Testing in AfRica (STAR) 
Organisation Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe)
Country Zimbabwe, Republic of 
Sector Charity/Non Profit 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health
Start Year 2015
 
Description HIV Self-Testing in AfRica (STAR) 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health
Start Year 2015
 
Description HIV Self-Testing in AfRica (STAR) 
Organisation The Wellcome Trust Ltd
Department Malawi-Liverpool Wellcome Trust Clinical Research Programme
Country Malawi, Republic of 
Sector Charity/Non Profit 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health
Start Year 2015
 
Description HIV Self-Testing in AfRica (STAR) 
Organisation University College London (UCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health
Start Year 2015
 
Description HIV Self-Testing in AfRica (STAR) 
Organisation World Health Organization (WHO)
Department UNITAID
Country Switzerland, Swiss Confederation 
Sector Public 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health
Start Year 2015
 
Description HIV epidemiology in the Middle East and North Africa 
Organisation Weill Cornell Medical College
Department Weill Cornell Medical College in Qatar
Country Qatar, State of 
Sector Academic/University 
PI Contribution PhD supervision
Collaborator Contribution Analysis and modelling
Impact 4 papers published, details in publications section of submission Multi-disciplinary: epidemiology, modelling
Start Year 2012
 
Description HIV/VL India 
Organisation Médecins Sans Frontières (MSF)
Country France, French Republic 
Sector Charity/Non Profit 
PI Contribution Trial design and analysis
Collaborator Contribution Leading clinical trial of drugs against visceral leishmaniasis in HIV co-infected patients
Impact Multi-disciplinary: epidemiology, public health
Start Year 2016
 
Description HPV Vaccine Trial - DoRIS 
Organisation University of York
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Member of the team funded by this award is a PI on the grant.
Collaborator Contribution Co-investigator on grant; immunology assays for vaccine trial
Impact None yet
Start Year 2016
 
Description HPV vaccine trial - DoRIS 
Organisation Catalan Institute of Oncology (ICO)
Department Cancer Epidemiology Research Programme (PREC)
Country Spain, Kingdom of 
Sector Hospitals 
PI Contribution Member of the team is PI on this grant.
Collaborator Contribution co-investigator on grant; HPV assays for vaccine trial
Impact None yet
Start Year 2016
 
Description HPV vaccine trial - DoRIS 
Organisation Karolinska Institute
Country Sweden, Kingdom of 
Sector Academic/University 
PI Contribution Member of research team is PI on this grant.
Collaborator Contribution co-investigator on grant; immunology assays for vaccine trial
Impact None yet
Start Year 2016
 
Description HPV vaccine trial - DoRIS 
Organisation National Institutes of Health (NIH)
Department National Cancer Institute (NCI)
Country United States of America 
Sector Public 
PI Contribution Member of team is PI on this grant
Collaborator Contribution co-investigator on grant; immunology assays for vaccine trial
Impact None yet
Start Year 2016
 
Description HPV vaccine trial - DoRIS 
Organisation National Institutes of Health (NIH)
Country United States of America 
Sector Public 
PI Contribution sharing of HPV vaccine immunogenicity data
Collaborator Contribution sharing of HPV vaccine efficacy data for immunobridging
Impact None yet
Start Year 2016
 
Description HomeACF 
Organisation University of the Witwatersrand
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: public health, health economics, statistics
Start Year 2016
 
Description IRD TB Programme Evaluation 
Organisation Interactive Research and Development
Country Pakistan, Islamic Republic of 
Sector Charity/Non Profit 
PI Contribution Co-design of evaluation of TB control programme through prevalence surveys and will do the analysis
Collaborator Contribution Co-design and running of evaluation
Impact Multi-disciplinary: Epidemiology, public health, statistics
Start Year 2016
 
Description Ilorin-Gambia-LSHTM group on sickle cell disease 
Organisation Medical Research Council (MRC)
Department Medical Research Council (MRC), MRC Laboratories, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Design and coordination of the randomized trial
Collaborator Contribution Conducted the clinic-based trial
Impact Evidence to support policy change for the management of sickle cell patients in malaria endemic areas. This collaboration is multi-disciplinary involving clinical medicine, epidemioogy, statistics, molecular biology.
Start Year 2010
 
Description Ilorin-Gambia-LSHTM group on sickle cell disease 
Organisation University of Ilorin Teaching Hospital, Nigeria
Country Nigeria, Federal Republic of 
Sector Academic/University 
PI Contribution Design and coordination of the randomized trial
Collaborator Contribution Conducted the clinic-based trial
Impact Evidence to support policy change for the management of sickle cell patients in malaria endemic areas. This collaboration is multi-disciplinary involving clinical medicine, epidemioogy, statistics, molecular biology.
Start Year 2010
 
Description Leaving no-one behind 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Co-investigator
Collaborator Contribution Study co-ordination and analysis
Impact Discipline: social science
Start Year 2016
 
Description Lung disease in HIV infected children 
Organisation Biomedical Research and Training Institute (BRTI)
Country Zimbabwe, Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical and epidemiological collaboration
Collaborator Contribution Leadership and all aspects of the trial
Impact Trial initiating in 2016.
Start Year 2014
 
Description Lung disease in HIV infected children 
Organisation University of Liverpool
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Statistical and epidemiological collaboration
Collaborator Contribution Leadership and all aspects of the trial
Impact Trial initiating in 2016.
Start Year 2014
 
Description Lung disease in HIV infected children 
Organisation University of Tromso
Country Norway, Kingdom of 
Sector Academic/University 
PI Contribution Statistical and epidemiological collaboration
Collaborator Contribution Leadership and all aspects of the trial
Impact Trial initiating in 2016.
Start Year 2014
 
Description MCUTS 
Organisation Grassroot Soccer
Country South Africa, Republic of 
Sector Charity/Non Profit 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact 2 papers published - detail in publications section of researchfish submission Multi-disciplinary: epidemiology, public health
Start Year 2013
 
Description MDR-TB infection control 
Organisation Queen Margaret University Edinburgh
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution co-design of study and analysis
Collaborator Contribution co-design, coordination, ethnographic work, policy review, laboratory work, health economics
Impact Multi-disciplinary: Epidemiology, public health, health economics, modelling, anthropology, statistics
Start Year 2017
 
Description MDR-TB infection control 
Organisation University College London (UCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution co-design of study and analysis
Collaborator Contribution co-design, coordination, ethnographic work, policy review, laboratory work, health economics
Impact Multi-disciplinary: Epidemiology, public health, health economics, modelling, anthropology, statistics
Start Year 2017
 
Description MDR-TB infection control 
Organisation University of Cape Town
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution co-design of study and analysis
Collaborator Contribution co-design, coordination, ethnographic work, policy review, laboratory work, health economics
Impact Multi-disciplinary: Epidemiology, public health, health economics, modelling, anthropology, statistics
Start Year 2017
 
Description MDR-TB infection control 
Organisation University of KwaZulu-Natal
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution co-design of study and analysis
Collaborator Contribution co-design, coordination, ethnographic work, policy review, laboratory work, health economics
Impact Multi-disciplinary: Epidemiology, public health, health economics, modelling, anthropology, statistics
Start Year 2017
 
Description MENISCUS 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Leadership, design and analysis
Collaborator Contribution Study co-ordination
Impact Outcome: Funding of JGHT trials development grant Multi-disciplinary: epidemiology, social science
Start Year 2015
 
Description MENISCUS2 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Leadership, design and analysis
Collaborator Contribution Study co-ordination
Impact Multi-disciplinary: epidemiology, social science
Start Year 2017
 
Description Malaria elimination trial 
Organisation University of Marseilles
Country France, French Republic 
Sector Academic/University 
PI Contribution LSHTM are responsible for the co-ordination of the trials.
Collaborator Contribution The University of Marseilles is contributing in terms of statistical spatial analysis, and genotyping to identify parasite strains.
Impact No outputs as yet to report.
Start Year 2013
 
Description Monitoring and Evaluation of implementation of interventions for VL in Africa and Asia 
Organisation Drugs for Neglected Diseases initiative (DNDi)
Country Switzerland, Swiss Confederation 
Sector Private 
PI Contribution Contributing to design and analysis of surveys
Collaborator Contribution Project management, intellectual input
Impact Multi disciplinary - Epidemiology, public health, statistics
Start Year 2014
 
Description Monitoring and Evaluation of implementation of interventions for VL in Africa and Asia 
Organisation Mott Macdonald UK Ltd
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Private 
PI Contribution Contributing to design and analysis of surveys
Collaborator Contribution Project management, intellectual input
Impact Multi disciplinary - Epidemiology, public health, statistics
Start Year 2014
 
Description Monitoring and Evaluation of implementation of interventions for VL in Africa and Asia 
Organisation Médecins Sans Frontières (MSF)
Country France, French Republic 
Sector Charity/Non Profit 
PI Contribution Contributing to design and analysis of surveys
Collaborator Contribution Project management, intellectual input
Impact Multi disciplinary - Epidemiology, public health, statistics
Start Year 2014
 
Description Namibia Malaria Elimination Partnership (NAMEP) 
Organisation Clinton Health Access Initiative (CHAI)
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme
Impact "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Namibia Malaria Elimination Partnership (NAMEP) 
Organisation National Vector-borne Diseases Control Programme (NVDCP)
Country Namibia, Republic of 
Sector Public 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme
Impact "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Namibia Malaria Elimination Partnership (NAMEP) 
Organisation University of California, San Fransisco (UCSF)
Country United States of America 
Sector Academic/University 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme
Impact "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Namibia Malaria Elimination Partnership (NAMEP) 
Organisation University of Namibia
Country Namibia, Republic of 
Sector Academic/University 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme
Impact "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Namibia Malaria Elimination Partnership (NAMEP) 
Organisation University of the Witwatersrand
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance; support to namtional Malaria Control programme
Impact "Trial Protocol; Smith, J. L., Auala, J., Haindongo, E., Uusiku, P., Gosling, R., Kleinschmidt, I., Mumbengegwi, D., Sturrock, H. J. W. (2017). Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia. Malaria Journal, 16, 70. http://doi.org/10.1186/s12936-017-1719-x" Multi-disciplinary: Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Newton Household Screening - Aurum (Asibamisane) 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Study design and analysis
Collaborator Contribution Study design and co-ordination
Impact Multi-disciplinary: public health, health economics, statistics, qualitative
Start Year 2016
 
Description OFLOTUB 
Organisation Government of South Africa
Department Medical Research Council of South Africa (MRC)
Country South Africa, Republic of 
Sector Public 
PI Contribution Contributed to trial design, conduct of trial, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014).
 
Description OFLOTUB 
Organisation Ignace Deen Hospital
Country Guinea, Republic of 
Sector Hospitals 
PI Contribution Contributed to trial design, conduct of trial, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014).
 
Description OFLOTUB 
Organisation Institut de recherche pour le développement (IRD)
Country France, French Republic 
Sector Public 
PI Contribution Contributed to trial design, conduct of trial, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014).
 
Description OFLOTUB 
Organisation Institute of Tropical Medicine Antwerp
Country Belgium, Kingdom of 
Sector Academic/University 
PI Contribution Contributed to trial design, conduct of trial, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014).
 
Description OFLOTUB 
Organisation National Hospital of Pneumo-Phtisiology
Country Benin, Republic of 
Sector Hospitals 
PI Contribution Contributed to trial design, conduct of trial, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014).
 
Description OFLOTUB 
Organisation Programme National de Lutte contre la Tuberculose
Country Senegal, Republic of 
Sector Public 
PI Contribution Contributed to trial design, conduct of trial, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014).
 
Description OFLOTUB 
Organisation University Hospitals in Paris
Country France, French Republic 
Sector Academic/University 
PI Contribution Contributed to trial design, conduct of trial, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014).
 
Description OFLOTUB 
Organisation World Health Organization (WHO)
Department Tropical Disease Research (TDR)
Country Switzerland, Swiss Confederation 
Sector Public 
PI Contribution Contributed to trial design, conduct of trial, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Results presented at the Union TB conference in Paris, 2013. Paper published on trial design (Trials, 2012) and main trial results (NEJM, 2014).
 
Description Observational study: Bioko Island Malaria Control Projects, Phase I 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions
Collaborator Contribution Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas
Impact Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888
 
Description Observational study: Bioko Island Malaria Control Projects, Phase I 
Organisation Medical Care Development International (MCDI)
Country United States of America 
Sector Private 
PI Contribution Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions
Collaborator Contribution Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas
Impact Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888
 
Description Observational study: Bioko Island Malaria Control Projects, Phase I 
Organisation University of Texas
Country United States of America 
Sector Academic/University 
PI Contribution Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions
Collaborator Contribution Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas
Impact Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888
 
Description Observational study: Bioko Island Malaria Control Projects, Phase I 
Organisation Yale University
Country United States of America 
Sector Academic/University 
PI Contribution Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions
Collaborator Contribution Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas
Impact Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888
 
Description PANGEA 
Organisation University College London (UCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution We will be contributing specimens (from PopART trial) to an international collaboration using sequencing and phylogenetic analysis to better understand the transmission dynamics of HIV.
Collaborator Contribution Co-ordination; organisation of sequencing pipeline; workshops; financial management.
Impact Multi-disciplinary: Epidemiology, public health
Start Year 2013
 
Description PREMIUM 
Organisation Sangath
Country India, Republic of 
Sector Charity/Non Profit 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact 3 papers published, detail in publications section of submission Multi-disciplinary: epidemiology, public health
Start Year 2010
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Bill and Melinda Gates Foundation
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Centers for Disease Control and Prevention (CDC)
Country United States of America 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Georgia Institute of Technology
Country United States of America 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Ghana Health Service
Country Ghana, Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Health Protection and Research Organisation (HPRO)
Country Afghanistan, Islamic Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation HealthNet
Country Afghanistan, Islamic Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Ifakara Health Institute
Country Tanzania, United Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Kilimanjaro Christian Medical Centre (KCMS)
Country Tanzania, United Republic of 
Sector Hospitals 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Kintampo Health Research Centre
Country Ghana, Republic of 
Sector Hospitals 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Makerere University
Country Uganda, Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Merlin, Afghanistan
Country Afghanistan, Islamic Republic of 
Sector Private 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Ministry of Health, Uganda
Country Uganda, Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation National Institute for Medical Research, Tanzania
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation National Malaria Control Programme, Cambodia
Country Cambodia, Kingdom of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation National Malaria Control Programme, Tanzania
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation The Karolinska Institute
Department Public Health Science Karolinska Institute
Country Sweden, Kingdom of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of California
Department University of California, San Francisco
Country United States of America 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Cape Town
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Copenhagen
Country Denmark, Kingdom of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Malawi
Country Malawi, Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Nigeria
Country Nigeria, Federal Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Yaoundé
Country Cameroon, Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Zanzibar Malaria Control Program (ZMCP)
Country Tanzania, United Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: TB preventive therapy and case finding with the consortium to respond effectively to the AIDS and TB epidemics (CREATE) 
Organisation Johns Hopkins University
Country United States of America 
Sector Academic/University 
PI Contribution TEG has contributed to the design of two clinical trials: Zamstar and Thibela TB. We have also developed the trial protocols and provided statistical support and led on data analysis.
Collaborator Contribution Collaborative involvement in statistical analysis of cluster randomised trials and data management of large field-based studies
Impact Both trials have been completed successfully. Zamstar results presented at Union World Conference on Lung Health (2011) and CROI (2012). Thibela results presented at CROI (2012) and the South African TB Conference (2012). Trial results have been published - Zamstar in Lancet (2013) and Thibela in NEJM (2014). Several publications are in progress and we intend to apply the learning from both trials to future trial design.
Start Year 2006
 
Description PrEP demonstration projectc 
Organisation Institute of Infectious Disease and Molecular Medicine (IIDMM)
Department Desmond Tutu HIV Centre
Country South Africa, Republic of 
Sector Public 
PI Contribution co-design of study and analysis; coordination of project at the Africa Centre site
Collaborator Contribution co-design, coordination of project at 2 other sites (Cape Town & Soweto)
Impact Multi-disciplinary: epidemiology, public health, health economics, social science, statistics
Start Year 2016
 
Description PrEP demonstration projectc 
Organisation University College London (UCL)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution co-design of study and analysis; coordination of project at the Africa Centre site
Collaborator Contribution co-design, coordination of project at 2 other sites (Cape Town & Soweto)
Impact Multi-disciplinary: epidemiology, public health, health economics, social science, statistics
Start Year 2016
 
Description PrEP demonstration projectc 
Organisation University of Cape Town
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution co-design of study and analysis; coordination of project at the Africa Centre site
Collaborator Contribution co-design, coordination of project at 2 other sites (Cape Town & Soweto)
Impact Multi-disciplinary: epidemiology, public health, health economics, social science, statistics
Start Year 2016
 
Description PrEP demonstration projectc 
Organisation University of the Witwatersrand
Department Perinatal HIV Research Unit
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution co-design of study and analysis; coordination of project at the Africa Centre site
Collaborator Contribution co-design, coordination of project at 2 other sites (Cape Town & Soweto)
Impact Multi-disciplinary: epidemiology, public health, health economics, social science, statistics
Start Year 2016
 
Description Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa 
Organisation Institute of Tropical Medicine Antwerp
Country Belgium, Kingdom of 
Sector Academic/University 
PI Contribution study design, statistical analysis, co-investigators
Collaborator Contribution priniciple investiagor; sample testing; significant intellectual input and exchange of ideas
Impact Results pending; analyses currently underway
Start Year 2012
 
Description Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Intervention Trials Unit (MITU)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution study design, statistical analysis, co-investigators
Collaborator Contribution priniciple investiagor; sample testing; significant intellectual input and exchange of ideas
Impact Results pending; analyses currently underway
Start Year 2012
 
Description Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa 
Organisation National Institute for Medical Research, Tanzania
Department NIMR Mbeya Research Centre (Formerly known as; Mbeya Medical Research Programme, MMPR)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution study design, statistical analysis, co-investigators
Collaborator Contribution priniciple investiagor; sample testing; significant intellectual input and exchange of ideas
Impact Results pending; analyses currently underway
Start Year 2012
 
Description RKSK evaluation 
Organisation Public Health Foundation of India
Country India, Republic of 
Sector Public 
PI Contribution Co-design of evaluation of governmental adolescent health programme ("RKSK") and will do the analysis
Collaborator Contribution Co-design and running of evaluation
Impact Outcome: successful grant application to the MRC Multi-disciplinary: Epidemiology, public health, statistics
Start Year 2016
 
Description SEHER 
Organisation Sangath
Country India, Republic of 
Sector Charity/Non Profit 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health
Start Year 2013
 
Description STAMP 
Organisation Harvard University
Country United States of America 
Sector Academic/University 
PI Contribution Chief-Investigator, Study design and analysis
Collaborator Contribution Study design, co-ordination, economic modelling, trial recruitment
Impact PMID: 27007773; 27659507 ; 27638038; 26266773 Multi-disciplinary: public health, health economics, statistics
Start Year 2015
 
Description STAMP 
Organisation MRC and the Department for International Development (DFID)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution Chief-Investigator, Study design and analysis
Collaborator Contribution Study design, co-ordination, economic modelling, trial recruitment
Impact PMID: 27007773; 27659507 ; 27638038; 26266773 Multi-disciplinary: public health, health economics, statistics
Start Year 2015
 
Description STAMP 
Organisation The Wellcome Trust Ltd
Department Malawi-Liverpool Wellcome Trust Clinical Research Programme
Country Malawi, Republic of 
Sector Charity/Non Profit 
PI Contribution Chief-Investigator, Study design and analysis
Collaborator Contribution Study design, co-ordination, economic modelling, trial recruitment
Impact PMID: 27007773; 27659507 ; 27638038; 26266773 Multi-disciplinary: public health, health economics, statistics
Start Year 2015
 
Description STAMP 
Organisation University of Cape Town
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Chief-Investigator, Study design and analysis
Collaborator Contribution Study design, co-ordination, economic modelling, trial recruitment
Impact PMID: 27007773; 27659507 ; 27638038; 26266773 Multi-disciplinary: public health, health economics, statistics
Start Year 2015
 
Description Seasonal Malaria Chemoprevention working group 
Organisation Roll Back Malaria
Country Switzerland, Swiss Confederation 
Sector Charity/Non Profit 
PI Contribution Chairing monitoring and evaluation subcommittee.
Collaborator Contribution Members of the monitoring and evaluation subcommittee.
Impact Regional meetings of malaria control programme managers in west Africa
Start Year 2013
 
Description Seasonal Malaria Chemoprevention working group 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Chairing monitoring and evaluation subcommittee.
Collaborator Contribution Members of the monitoring and evaluation subcommittee.
Impact Regional meetings of malaria control programme managers in west Africa
Start Year 2013
 
Description Seasonal Malaria Chemoprevention working group 
Organisation Worldwide Antimalarial Resistance Networkn WWARN
Country Global 
Sector Charity/Non Profit 
PI Contribution Chairing monitoring and evaluation subcommittee.
Collaborator Contribution Members of the monitoring and evaluation subcommittee.
Impact Regional meetings of malaria control programme managers in west Africa
Start Year 2013
 
Description Statistical support: IPT for the prevention of malaria and related complications in patients with sickle-cell disease in Nigeria 
Organisation University of Ilorin Teaching Hospital, Nigeria
Country Nigeria, Federal Republic of 
Sector Academic/University 
PI Contribution Statistical support- analysis and reporting of results
Collaborator Contribution Study conducted in Nigeria
Impact Manuscript currently being prepared.
Start Year 2013
 
Description Statistical support: MRC The Gambia 
Organisation Medical Research Council (MRC)
Department MRC Laboratories, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Research support
Collaborator Contribution Increased research output
Impact Large number of collaborative research papers and impact on policy. Secured collaborative research funding.
 
Description Statistical support: MRC Uganda 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Study design, data analysis, writing and publishing papers, PhD supervision, writing grant proposals, support for quinquennial review proposal
Collaborator Contribution Mutually reinforcing collaboration involving exchange of ideas
Impact Collaborative studies and research papers; ; successful outcome of MRC quinquennial review
 
Description Statistical support: Mwanza MITU/NIMR 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Intervention Trials Unit (MITU)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Epidemiological and statistical input to field studies; design of new studies and preparation of funding applications; capacity building
Collaborator Contribution Collaborative involvement in and field sites for studies of the epidemiology and control of HIV and related infections
Impact HIV microbicide and vaccine feasibility studies, and studies of HPV vaccination and epidemiology successfully completed. Studies of chronic diseases and structural interventions to reduce gender violence ongoing
Start Year 2006
 
Description Statistical support: The relationship between anaemia and pubertal growth spurt in Tanzanian sickle cell patients 
Organisation Muhimbili Wellcome Programme
Country Tanzania, United Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical support- analysis and data management
Collaborator Contribution Study conducted in Tanzania
Impact Research instigated.
Start Year 2013
 
Description Statistical support: Wellcome Trust Bloomsbury Centre Fellows 
Organisation The Wellcome Trust Ltd
Department Wellcome Trust Bloomsbury Centre; Wellcome Trust
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Epidemiological and statistical support for Wellcome Trust fellows
Collaborator Contribution Collaborative involvement in field research carried out by Wellcome Trust fellows
Impact Successful completion of wide range of field studies including publications in peer-review journals
 
Description Statistical support: the impact of maternal infection with M. Tuberculosis on the infant response to BCG immunisation 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Statistical design and analysis of the study
Collaborator Contribution Design of the study, obtaining funding, co-ordinating the study
Impact No outputs as yet.
Start Year 2013
 
Description Support for design and analysis of clinical research projects & support for data management and reporting of clinical projects 
Organisation Drugs for Neglected Diseases initiative (DNDi)
Country Switzerland, Swiss Confederation 
Sector Private 
PI Contribution We provide ongoing statistical and epidemiological support for trials of the treatment of visceral leishmaniasis in multi-centre studies in East Africa, coordinated from a data centre in KEMRI, Nairobi. The grant also supports participation in a Data Safety and Monitoring Committee for similar trials, also conducted under the sponsorship of DNDi in India and Bangladesh.
Collaborator Contribution Implementation of trial, coordination and management.
Impact Paper led to informing national treatment policy in Sudan, Kenya, Uganda and Ethiopia. (Sodium stibogluconate plus paramomycin incorporated as the new standard treatment regimin for patients with VL)
 
Description TB China: CRT of medication monitor in TB case management 
Organisation Bill and Melinda Gates Foundation
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Access to data
Impact Follow-on study to earlier CRT. Protocol & CRFs being drafted.
Start Year 2010
 
Description TB China: CRT of medication monitor in TB case management 
Organisation Government of China
Department Ministry of Health of the People's Republic of China
Country China, People's Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Access to data
Impact Follow-on study to earlier CRT. Protocol & CRFs being drafted.
Start Year 2010
 
Description Targetted control to eliminate malaria in Senegal 
Organisation Université Cheikh Anta Diop de Dakar, Dakar
Country Senegal, Republic of 
Sector Academic/University 
PI Contribution Design and coordination and analysis of the cluster randomized trial
Collaborator Contribution They led the coordination of field activities
Impact The trial result will be available Q4 2015. This collaboration is multi-disciplinary involving epidemiology, statistics, economics, social science, clinical medicine, molecular biology, entomology, public health, parasitology.
Start Year 2011
 
Description Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission 
Organisation Clinton Health Access Initiative (CHAI)
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance
Impact Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission 
Organisation National Vector-borne Diseases Control Programme (NVDCP)
Country Namibia, Republic of 
Sector Public 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance
Impact Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission 
Organisation University of California
Department University of California, San Francisco
Country United States of America 
Sector Academic/University 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance
Impact Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission 
Organisation University of Namibia
Country Namibia, Republic of 
Sector Academic/University 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance
Impact Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Trial to evaluate targeted parasite elimination (TPE) as a strategy to interrupt malaria transmission 
Organisation University of the Witwatersrand
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Trial design; funding of vector control component through Wits University.
Collaborator Contribution Funding of trial; logistics; trial management and governance
Impact Trial protocol. Multi disciplinary - Epidemiology, Disease Control, Pharmacology, Entomology. Vector Control, Statistics. Modelling, Immunology
Start Year 2015
 
Description Vanderbilt-collaboration 
Organisation Vanderbilt University
Country United States of America 
Sector Academic/University 
PI Contribution Study design
Collaborator Contribution Study design
Impact Discipline: Trial design
Start Year 2016
 
Description XPEL TB 
Organisation University of California, San Fransisco (UCSF)
Country United States of America 
Sector Academic/University 
PI Contribution Study design and analysis
Collaborator Contribution Study design and co-ordination
Impact Multi-disciplinary: public health, health economics, statistics
Start Year 2016
 
Description Xenomonitoring of lymphatic filariasis in Recife, Brazil 
Organisation Oswaldo Cruz Foundation (Fiocruz)
Country Brazil, Federative Republic of 
Sector Public 
PI Contribution Leadership (Anita Ramesh) of the project which aims to establish a xenomonitoring system
Collaborator Contribution Cynthia Braga is co-PI. CPqAM personnel working on the xenomonitoring project. Lab facilities.
Impact None so far this year.
 
Description ZikAlliance 
Organisation Sao Paulo State University
Country Brazil, Federative Republic of 
Sector Academic/University 
PI Contribution Epidemiology of ZIKV with a focus on natural history, virus detection over time and disability.
Collaborator Contribution University of Sao Paolo, Brazil will carry out the field activities. Heidelberg leads the large Consortium and co-ordinate a study in pregnant women and children
Impact Multi-disciplinary: Epidemiology, public health, statistics
Start Year 2016
 
Description ZikAlliance 
Organisation University of Heidelberg
Country Germany, Federal Republic of 
Sector Academic/University 
PI Contribution Epidemiology of ZIKV with a focus on natural history, virus detection over time and disability.
Collaborator Contribution University of Sao Paolo, Brazil will carry out the field activities. Heidelberg leads the large Consortium and co-ordinate a study in pregnant women and children
Impact Multi-disciplinary: Epidemiology, public health, statistics
Start Year 2016
 
Description ZikaPLAN 
Organisation Umea University
Country Sweden, Kingdom of 
Sector Academic/University 
PI Contribution Coordination of focus group and related activities on use of wearable technologies for protection against mosquito vectors of Zika and other arboviruses.
Collaborator Contribution Universidad del Valle will carry out the field activities.
Impact Multi-disciplinary - Social sciences, entomology, public health.
Start Year 2016
 
Description Zimbabwe study for Enhancing Testing and Improving Treatment of HIV in Children 
Organisation Biomedical Research and Training Institute (BRTI)
Country Zimbabwe, Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical and epidemiological collaboration
Collaborator Contribution Leadership and all aspects of the trial
Impact Trial will finish mid 2016
Start Year 2012
 
Description Zvandiri 
Organisation Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe)
Country Zimbabwe, Republic of 
Sector Charity/Non Profit 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health
Start Year 2014
 
Description Zvandiri 
Organisation Viiv Healthcare
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Private 
PI Contribution Trial design and analysis
Collaborator Contribution Trial design and co-ordination
Impact Multi-disciplinary: epidemiology, public health
Start Year 2014
 
Description DENCO 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk on how to clinical classification of dengue

Positive feedback on insightfulness of presentation into clinical classification of dengue
Year(s) Of Engagement Activity 2014
URL http://www.redaedes.org/curso/presentacion.htm
 
Description Impact of insecticide resistance on the effectiveness of LLINs - current knowledge and gaps 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact WHO convened Evidence Review Group to define the conditions for deployment of long-lasting insecticidal nets treated with a pyrethroid and the synergist piperonyl butoxide. WHO Global Malaria Programme draft recommendation on the deployment of bi-treated nets to be used in areas where malaria vectors are pyrethroid resistant
Year(s) Of Engagement Activity 2015
URL http://www.who.int/malaria/publications/atoz/use-of-pbo-treated-llins/en/
 
Description LaVIISWA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral abstract accepted for presentation at EAACI

None that we are aware of at this stage
Year(s) Of Engagement Activity 2014
 
Description OFLOTUB Late Breaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation generated lively discussion

Several tweets and news articles online
Year(s) Of Engagement Activity 2013
 
Description OFLOTUB Podcast 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Increased awareness of TB treatment trials

None that we are aware of at this stage
Year(s) Of Engagement Activity 2014
URL http://soundcloud.com/lshtm/tbtreatment
 
Description PopART Podcast (January 2014) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Introduced an alternative approach to controlling HIV in southern Africa - one that focuses on treatment rather than prevention.

None reported
Year(s) Of Engagement Activity 2014
URL http://www.scidev.net/global/hiv-aids/multimedia/hiv-treatment-as-prevention-in-africa.html
 
Description PopART Talk at IAS 2015 Conference, Vancouver 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Presented PopART data on achievement of 90-90-90 UNAIDS targets to mixed group of policy-makers and scientists
Year(s) Of Engagement Activity 2015
 
Description Poster on LEAP trials at American Society of Tropical Medicine & Hygiene 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Comparison of difference methods of estimating drug efficacy from a sequential trial.
Year(s) Of Engagement Activity 2016
 
Description Poster on spatial analysis at ISCE conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster on impact of non-participation on power in cluster randomised trials: an application to mass drug administration interventions for trachoma control
Year(s) Of Engagement Activity 2016
 
Description Presentation at IAS Durban (talk) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Summary of pilot results and adaptation of design of study of clinical performance of HIV self testing among intended users in Zambia
Year(s) Of Engagement Activity 2016
 
Description Presentation on Global Malaria Landscape at Elimination 8 board meeting (talk) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Provided information to board members to facilitate decision making
Year(s) Of Engagement Activity 2016
 
Description Presentation on Malaria Chemoprevention to Medecins Sans Frontieres 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I gave a 45-minute lecture to students on the MSF course Global Health and Humanitarian Medicine, followed by a question and answer session.

This was later made available online to students following the MSF course remotely.
Year(s) Of Engagement Activity 2015
 
Description Presentation on PopART intervention uptake (poster) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Uptake of PopART/HPTN071 intervention after two years
Year(s) Of Engagement Activity 2016
 
Description Presentation on microcephaly in Brazil 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Shared information on microcephaly in Pernambuco, Brazil.
Year(s) Of Engagement Activity 2016
URL http://www.univalle.edu.co/salud/virus-del-zika-un-problema-para-la-salud-publica-en-colombia
 
Description Presentation to Malaria Policy Advisory Committee 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Impact of insecticide resistance on malaria burden and efficacy of preventitive tools - WHO advise on continued use of LLINs as basic protection
Year(s) Of Engagement Activity 2016
URL http://www.who.int/malaria/publications/atoz/insecticide-resistance-implications/en
 
Description Presentation to policy-makers at WHO global malaria programme 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact I was invited to present work from my MRC-funded Population health scientist Fellowship at the WHO global malaria programme in January 2016
Year(s) Of Engagement Activity 2016
 
Description Public engagement World Statistics Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Workshop for year 10 students at Maria Fidelis School in Camden for world statistics day, encouraging school kids to consider a career in STEM subjects.
Year(s) Of Engagement Activity 2015
URL http://blogs.lshtm.ac.uk/news/2015/11/18/unpicking-statistics-the-stories-behind-the-numbers/
 
Description SMC 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Policymakers/parliamentarians
Results and Impact Regional meetings of malaria control managers to help them develop implemetation plans for SMC and to monitor impact

13 countries have adopted SMC as policy and 6 have started implementation
Year(s) Of Engagement Activity 2012,2013,2014
 
Description Science Museum Lates - Ebola 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Engagement with general public via Science Museum Lates, to have conversations with members of the public about LSHTM's work on Ebola
Year(s) Of Engagement Activity 2016
URL http://blogs.lshtm.ac.uk/alumni/2016/12/13/infectious-curiosity-about-infection-research-at-the-scie...
 
Description Spatial analysis at International Society for Clinical Biostatistics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk on evidence of geographical spillover effect of interventions against mosquito vectors of dengue
Year(s) Of Engagement Activity 2016
 
Description Talk at ASTMH Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk on long lasting insecticidal nest (LLIN) provide protection against malaria infection even in areas of insecticide resistance - WHO advise on continued use of LLINs as basic protection.
Year(s) Of Engagement Activity 2016
 
Description Talk at International AIDS Society Durban (invited) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Adaptation of PopART trial design to account for changes in WHO treatment guidelines for HIV
Year(s) Of Engagement Activity 2016
 
Description Talk at MSF on chemoprevention (July 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented on various malaria chemoprevention strategies to MSF programme staff developing malaria control packages.
Year(s) Of Engagement Activity 2016
 
Description Talk at Nagasaki University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk at Nagasaki University on lessons learned from use of sequential methods in trials against visceral leishmaniasis.
Year(s) Of Engagement Activity 2016
 
Description Talk at University College London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Talk at UCL on analysis clustered data
Year(s) Of Engagement Activity 2016
 
Description Technical consultation on post-MDA surveillance for trachoma 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact WHO advisory group to inform decision making.
Year(s) Of Engagement Activity 2014