Construction of an Imaging Centre of Excellence (ICE) at the new South Glasgow University Hospital

Lead Research Organisation: University of Glasgow
Department Name: College of Medical, Veterinary &Life Sci

Abstract

The synergy between imaging and genomics technologies has been recognised as being an important driver to the future development of Stratified or Precision Medicine. The benefits of stratified medicine are now globally recognised, and Scotland is uniquely placed to capitalise on this potential, owing to its strong academic research base, advanced electronic health records within the NHS, and a strong industry presence in genomics, bioinformatics and diagnostics. The South Glasgow University Hospital represents an investment to Glasgow and Scotland in the region of £1Billion. When it opens in 2015, the new hospital will be the largest in Western Europe and will include maternity, paediatric and adult services on a single site. The Imagine Centre of Excellence (ICE), located at the new hospital, will uniquely accommodate a 7 Tesla MRI scanner together with other imaging modalities for clinical and research use, including 3T MRI and high resolution multi-slice CT, all networked and sharing staff with the large number of service scanners within the main hospital. This state-of-the-art equipment will be housed alongside clinical academic imaging specialists, NHS clinical physics expertise, innovation space for industry, and potential for expansion of precision medicine activities.The University of Glasgow led the development of the Scotland-wide £20M Stratified Medicine Scotland Innovation Centre (SMS-IC), which will be based adjacent to the ICE building. The co-location of ICE and SMS-IC will therefore provide significant added value to both centres.

The creation of an internationally competitive centre in medical imaging incorporating NHS, academic and industry partners will allow Glasgow to support a much greater volume and variety of clinical trials and translational development than currently, including the associated supply chain. The facility will be co-located alongside commercial, learning, research and clinical facilities, and will be accessible to indust partners and collaborators thus ensuring spin off benefits to the local Scottish company base of specialist CROs and other service providers.

The proposed facility will maximise and facilitate the economic impact from the clinical research excellence at the new South Glasgow University Hospital, and ensure the hospital site becomes a clinical research-driven UK exemplar of a Life Sciences cluster. As such, the proposal fully aligns with the Scottish Life Sciences Strategy and the facility will add significant value to existing assets in Scotland.

Technical Summary

The synergy between imaging and genomics technologies has been recognised by the Technology Strategy Board as being an important driver to the future development of Stratified or Precision Medicine. The benefits of stratified medicine are now globally recognised, and Scotland is uniquely placed to capitalise on this potential, owing to its strong academic research base, advanced electronic health records within the NHS, and a strong industry presence in genomics, bioinformatics and diagnostics. The University of Glasgow led the development of the Scotland-wide £20M Stratified Medicine Scotland Innovation Centre (SMS-IC), which will also based at the South Glasgow University Hospital campus. The focus of SMS-IC is on bringing together genome sequencing technology and the complex bioinformatics required to link genomic data with NHS clinical data to allow stratification of patients based on genetic profiles. The co-location of ICE and SMS-IC will therefore provide significant added value to both centres.

By linking clinical academics, NHS and industry together, the Imaging Centre of Excellence (ICE) will maximise and facilitate the economic impact from the clinical research excellence at the new South Glasgow University Hospital, and ensure the hospital site becomes a UK exemplar of a Life Sciences cluster. As such, the proposal fully aligns with the Scottish Life Sciences Strategy and the facility would add significant value to existing assets in Scotland.

Planned Impact

The ICE building is being designed to allow direct ambulatory access for patients, and the building will be linked to the new Clinical Research Facility to allow clinical trials to benefit from the advanced imaging technologies. The Glasgow MRI facility will offer a resource that will be uniquely valuable for researchers across the country, and central to its goals will be the application of advanced technology to understanding of human disease. The ability to undertake the most advanced imaging across the entire spectrum of clinical problems, encompassing acutely unwell or dependent patients, is a key principle of the research imaging facility.
Importantly, NHS Greater Glasgow & Clyde's catchment area covers a population of 2.8 million, and represents one of the most epidemiologically problematic areas of the UK including high co-morbidity and chronic disease. Therefore the clinical environment is certainly unique within the UK. Of course, for maximum clinical impact any imaging facility needs to be embedded within the hospital environment - so, for example, a 7T MRI scanner based in Oxford would not be of use to the large cohort of stroke patients in the West of Scotland. However, our ability to network with other 7T sites in the UK, as these develop, will contribute to the development of 7T skills, knowledge and expertise across the UK.

Ultimately the impact of ICE will extend to the whole patient population through the development of innovative diagnostics and medicines. It will also ensure that the new hospital becomes a UK exemplar for life sciences industry. NHS Greater Glasgow & Clyde already has the largest Clinical Physics NHS department in the UK and the largest imaging modality assets in Europe. The co-location of the Imaging Centre of Excellence will ensure the ability to recruit, train and retain the highest calibre of staff in diagnostic imaging, clinical physics and related disciplines. It will allow the hospital to provide unprecedented access to advanced diagnostic imaging for patients and greater access to advanced clinical research studies, including major international collaborations. We also anticipate that the co-location of ICE will attract specialist medical conferences to the hospital, and will also facilitate an entrepreneurial culture within the hospital to ensure the development and sustainability of NHS start-up companies.

Publications


10 25 50
 
Description Bioimaging tools and resource development 7 Tesla MRI
Amount £150,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 07/2017 
End 12/2018
 
Description Human Brain Project
Amount £487,239 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2016 
End 03/2018
 
Description MRC Neurosciences and Mental Health Board
Amount £123,537 (GBP)
Funding ID MR/N008537/1 
Organisation MRC-UK 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2016 
End 12/2018
 
Description The Precision Medicine Ecosystem
Amount £3,480,000 (GBP)
Organisation Scottish Government 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2016 
End 03/2017
 
Description UK7T Imaging Network: developing the ultra-field MRI platform for biomedical research. 
Organisation Cardiff University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution We are a founder member of the Network.
Collaborator Contribution We have been integral to the planning and governance of the Network.
Impact There are no outcomes to report at this time. The collaboration is multi-disciplinary - neuroscience; psychology; cardiovascular; imaging; electronics; informatics.
Start Year 2016
 
Description UK7T Imaging Network: developing the ultra-field MRI platform for biomedical research. 
Organisation Nottingham University Hospitals NHS Trust
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution We are a founder member of the Network.
Collaborator Contribution We have been integral to the planning and governance of the Network.
Impact There are no outcomes to report at this time. The collaboration is multi-disciplinary - neuroscience; psychology; cardiovascular; imaging; electronics; informatics.
Start Year 2016
 
Description UK7T Imaging Network: developing the ultra-field MRI platform for biomedical research. 
Organisation University of Cambridge
Department Wolfson Brain Imaging Centre
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution We are a founder member of the Network.
Collaborator Contribution We have been integral to the planning and governance of the Network.
Impact There are no outcomes to report at this time. The collaboration is multi-disciplinary - neuroscience; psychology; cardiovascular; imaging; electronics; informatics.
Start Year 2016
 
Description UK7T Imaging Network: developing the ultra-field MRI platform for biomedical research. 
Organisation University of Nottingham
Department School of Physics and Astronomy
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution We are a founder member of the Network.
Collaborator Contribution We have been integral to the planning and governance of the Network.
Impact There are no outcomes to report at this time. The collaboration is multi-disciplinary - neuroscience; psychology; cardiovascular; imaging; electronics; informatics.
Start Year 2016
 
Description UK7T Imaging Network: developing the ultra-field MRI platform for biomedical research. 
Organisation University of Oxford
Department Division of Clinical Neurology
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution We are a founder member of the Network.
Collaborator Contribution We have been integral to the planning and governance of the Network.
Impact There are no outcomes to report at this time. The collaboration is multi-disciplinary - neuroscience; psychology; cardiovascular; imaging; electronics; informatics.
Start Year 2016
 
Description 7 Tesla International Seminar series 2016-17 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact This is an International seminar series has been launched to foster multidisciplinary relationships between scientists and clinicians, further facilitate translational clinical research, and promote the development of 7T both in Glasgow and on the international stage. This programme is open to staff and students alike, as well as our NHS and industry partners and members of the public. This program has been run from September 2016 and has been well attended through the standing ad quality of the national and international speakers.
Year(s) Of Engagement Activity 2016,2017
URL http://www.gla.ac.uk/colleges/mvls/ice/seminars/#/previousseminars
 
Description Alison MacEwan & Sara Cebrian, Foreign & Commonwealth Office 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Raising government awareness of clinical innovation zone, Queen Elizabeth campus and ICE
Year(s) Of Engagement Activity 2016
 
Description College of Medical Veterinary & Life Sciences Industry Day 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact There were 311 delegates attended an all-day event focused on bringing together academia and the biomedical and life sciences industry with a focus on precision medicine. The event comprised a series of lectures and workshops including a panel discussion featuring the Imaging Centre of Excellence and its importance in precision medicine.
Year(s) Of Engagement Activity 2015
 
Description Delivery of 7 Tesla MRI Scanner Queen Elizabeth University Hospital November 2016. This was a significant event widely covered in the local press and TV and attended by all academic NHS Industry and funding partners involved in this project. It gained extensive impact and discussion in the local press in the subsequent days. 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The principal objectives of this event were to leverage the press coverage around this event to raise the profile of the ICE centre of excellence at a national level and also to acknowledge the contributions of the key partners in this event. The physical installation of the 7 Tesla scanner was a dramatic event and gained extensive TV and press coverage in Scottish TV stations and the regional press.
In terms of raising the profile of the regard the event has been an outstanding ICE centre and by extension the wider Queen Elizabeth University Hospital including our clinical innovation zone.
Year(s) Of Engagement Activity 2016
URL http://www.gla.ac.uk/news/archiveofnews/2016/december/headline_501585_en.html
 
Description Dr Barbara Blaney, Medicity 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Visit and presentation of ICE and Clinical Innovation zone plans to key management of local Medtech incubator group Medicity.
Year(s) Of Engagement Activity 2016
 
Description Harper VanSteenhouse, Director Biospyder California 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Visit and strategic discussion regarding opening of Biospyder presence within Clinical Innovation Zone and interaction with ICE
Year(s) Of Engagement Activity 2016
 
Description IAVI (International AIDS Vaccine Initiative) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Detailed Discussion regarding future collaboration and raising awareness of clinical innovation zone capabilities including imaging
Year(s) Of Engagement Activity 2016
 
Description Imaging Cente of Excellence : Project planning day and workshops Feb 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Project planning and development day
The purpose of this all day event was to bring together all of the internal and external stakeholders connected to and active in the delivery of the Imaging centre of excellence objectives. This comprised a selective group of academic NHS industry support staff with an active presence from the City of Glasgow. The day opened with an overview of the vision for ICE from industry partners Siemens and Professor David Porte, newly appointed Chair of MRI Physics. It then split into sub groups aligned specifically with the delivery work streams of the project encompassing the scientific and economic delivery work-streams with the overall ICE project plan. These engaged with a wider group of prospective users and advisors and addressed and stress tested a wide variety of issues related to delivery (technical issues, public engagement, industry partners, risk analysis etc). These sessions were moderated by an external facilitator and the results collated and will into a significant revision of the on going ICE delivery plan to be presented to the Board April 17.
Year(s) Of Engagement Activity 2017
 
Description Joe Manning, Scottish Government, Cities & Local Growth Unit, Innovation Team + other representatives - 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Meeting with UK government representatives to update on ICE in context of City Region City deal
Year(s) Of Engagement Activity 2016
 
Description John McCafferty, CEO Iontas 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Tour of facility and discussions of future collaboration with CEO of drug discovery company Iontas
Year(s) Of Engagement Activity 2017
 
Description Joint meeting of the Association of British Pharmaceutical Industry and the Chief Scientist Office, Scotland. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact This meeting was to make the Association of British Pharmaceutical Industry aware of major research initiatives in precision medicine and imaging in Scotland and to discuss the mechanisms for deeper engagement with the pharmaceutical industry in the UK.
Year(s) Of Engagement Activity 2016
 
Description Kenny Simmen, Janssen Research & Development 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Visit and tour of Clinical Innovation Zone facilities leading to strategic discussion around long term collaboration including Imaging as stratification tool
Year(s) Of Engagement Activity 2016
 
Description Kevin Rush & Anne Murray - Glasgow City Council 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Visit and presentation of Clinical Innovation zone and update on delivery plan for ICE with CITY Council as key partners in the City Region City Deal.
Year(s) Of Engagement Activity 2016
 
Description Launch of dedicated webpage 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Launch of dedicated webpage for Imaging Centre of Excellence as portal to general public
Year(s) Of Engagement Activity 2016
URL http://www.gla.ac.uk/colleges/mvls/ice/
 
Description Lena Wilson & Linda Hanna - Scottish Enterprise 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact In depth presentation of ICE to CEO of Scottish Enterprise leading to development of strategic engagement to support commercialisation activities in Clinical Innovation Zone through appointment of new business development manager.
Year(s) Of Engagement Activity 2017
 
Description Linda Hanna, Julia Brown and Neil Guthrie - Scottish Enterprise - tour of all facilities including ICE 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Tour of facility and discussion of strategic engagement with Scottish Economic development agencies
Year(s) Of Engagement Activity 2016
 
Description MP Robin Walker (Parliamentary Under Secretary of State at the Department of Exiting the European Union) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Tour of facilities and raising awareness with local MP with European brief
Year(s) Of Engagement Activity 2017
 
Description MSPs visit to Imaging Centre of Excellence Feb 2017 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact This visit hosted by Professor Dominiczak and welcomed senior Scottish Government Ministers Shona Robison MSP and Michael Russell MSP to the new Imaging Centre of Excellence in early February 2017.

Ms Robison, the Scottish Government Cabinet Secretary for Health, and Mr Russell, the Minister for UK Negotiations on Scotland's Place in Europe, first met with Vice Principal and Head of College, Professor Dame Anna Dominiczak, and were then given a tour of ICE by Dr Carol Clugston, the Chief Operating Officer of MVLS.The MSPs were also there to discuss the potential difficulties posed by Brexit and the implications for the NHS and EU funding for NHS and research collaborations. The visit provided and excellent opportunity to impress upon these senior policy makers the long term vision and impact of the ICE project and influence policy at a Scottish Government level.
Year(s) Of Engagement Activity 2017
URL http://www.gla.ac.uk/colleges/mvls/ice/news/headline_512661_en.html
 
Description Mahidol University visit , Thailand - 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation of Queen Elizabeth University Campus and future plans for Clinical Innovation Zone including ICE
Year(s) Of Engagement Activity 2016
 
Description Matthew Speers, CEO, Life Sciences, Department of International Trade 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation of strategic plans for development of Queen Elizabeth University Hospital Campus including ICE
Year(s) Of Engagement Activity 2016
 
Description Ministerial visit - Imaging Centre of Excellence (ICE) Breaking-ground Ceremony 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact We hosted the Minister for Universities and Science, Jo Johnson for a 'Breaking-ground' Ceremony for the new Imaging Centre of Excellence. The day included a series of scientific and commercial presentation appraising the Minister of the significance of the new Centre in imaging and precision medicine.
Year(s) Of Engagement Activity 2015
 
Description Neil Guthrie/Andrea Taylor/Ed Hutchison, Scottish Enterprise 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Visit and future planning meeting senior managers in Scottish Enterprise
Year(s) Of Engagement Activity 2016
 
Description Paul Lewis/Neil Francis - Scottish Enterprise - tour of QEUH 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Early update and awareness raising with senior Scottish Enterprise management in the initial phase of ICE planning
Year(s) Of Engagement Activity 2016
 
Description Sinclair Dunlop, Epidarex Capital 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Tour of facilities and discussion of future investment opportunities with CEO of local strategic VC group
Year(s) Of Engagement Activity 2017
 
Description Tim Cook, CEO, Apple - tour of all facilities including ICE 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Visit to ICE Integrated with award of Honorary degree to Tim Cook CEO of Apple. There was particular discussion on potential future collaboration on digital technology pertaining to both Imaging applications, Stratified Medicine and health tracking technology.
Year(s) Of Engagement Activity 2017
URL http://www.gla.ac.uk/myglasgow/news/archives/2017/february/headline_513206_en.html
 
Description Victor Dzau 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Significant presentations and planning with key US opinion leader and policy influencer in US government.
Year(s) Of Engagement Activity 2016
 
Description Visit by G Disley MD Cerno Health 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Visit by and Scientific presentation Mt Gary Disley MD Cerno Health 0 UK partner to Chinese Imaging company United Imaging - this is being followed up by visit within Industry day late March 2017
Year(s) Of Engagement Activity 2016
 
Description Visit by Tantaya Corp US 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Introduction to ICE project to prospective tenant in the Clinical Innovation Zone
Year(s) Of Engagement Activity 2016
 
Description Visit of the First Minister of Scotland. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact The purpose of this visit was to update the First Minister on the University of Glasgow's developments and research and clinical strategy at the Queen Elizabeth University Hospital campus. This highlighted the importance of the Imaging Centre of Excellence as a key part of the Scottish Precision Medicine ecosystem.
Year(s) Of Engagement Activity 2016