Brain networks in epilepsy: Endophenotypes and generative models

Lead Research Organisation: King's College London
Department Name: Clinical Neuroscience

Abstract

Epilepsy is the commonest serious brain disease, affecting 750,000 people in the UK. It causes catastrophic seizures, resulting in at least 1000 deaths per year in the UK. It is the commonest cause of repeated admission to hospital. About 1 in 3 of all people with epilepsy do not respond to any medication, and continue to have uncontrolled seizures. The personal, social and economic costs of epilepsy are very high.

It is not yet known how epileptic seizures start. There are clues from experiments in animals and genetic studies in people which suggest that epilepsy can be caused by a wide range of disturbances in brain cell function. Furthermore, there are different patterns of epileptic seizure, which occur in different combinations in different people, and associated with other specific findings in clinical tests. This has given rise to the view that epilepsy is at least 20 different diseases (or types of epilepsy), and that each type of epilepsy might have a different cause.

However, this does not explain some well-recognised aspects of epilepsy:

Firstly, although there may appear to be many causes, there are only small number of types of epileptic seizure; and an individual with epilepsy may suffer from several different types of seizure.
Secondly, epilepsy may sometimes be inherited within a family; if epilepsy were a set of entirely different diseases, it might be expected that within one family all affected members would have the same type of epilepsy. On the contrary, it is known that within some families there are affected individuals who have completely different types of epilepsy.
Thirdly, drugs for the treatment of epilepsy have broadly similar therapeutic effects across all types of seizure and epilepsy, with very few exceptions.

These observations suggest that there must be important mechanisms in common between different seizure types, and between different types of epilepsy.

It is increasingly recognised that functions of the brain are properties of complex networks of brain cells. We have worked for several years on new methods to identify whether brain networks in people with epilepsy have abnormal properties, and whether these properties allow seizures to occur. Using MRI brain scans, we have shown abnormalities of specific brain regions and their connections. Using electrical recordings of brain waves (EEG) we have shown that brain networks differ between people with epilepsy and people who do not have epilepsy; and that unaffected relatives of people with epilepsy may have similar brain networks to their affected relatives. Using computer models of how EEG activity is produced, we have shown that these inherited networks have an abnormal ability to suddenly switch to seizure activity.

In this Programme we build on this background, to examine four questions:
(1) Are brain networks which have an abnormal ability to generate seizures found across a range of common types of epilepsy?
(2) Are these network abnormalities inherited?
(3) Does successful treatment act by altering the properties of these brain networks?
(4) In people whose epilepsy spontaneously goes away, is this accompanied by a change in the properties of these brain networks?

We will collect MRI brain scans and EEGs from more than 150 people with epilepsy, in addition to their close family relatives, and a "control" group of people who have no personal or family connection with epilepsy. We will develop new methods to identify the relevant brain networks from MRI and EEG, and examine how these networks differ between people with epilepsy, their relatives and controls. We will also examine how these networks change over time (and how quickly they change) in response to starting treatment, and as a result of spontaneous remission of epilepsy. A special focus of this Programme is the development of new computer-based methods to identify the mechanisms by which seizures arise in these highly complex networks of the brain.

Technical Summary

We aim to explain the emergence of epileptic seizures from the interplay between dynamic properties of localised brain regions and network structures connecting them, using a combination of methods from connectomics and dynamic modelling.

We will develop MRI methods to describe distributed abnormalities of grey matter, structural connectivity and functional connectivity in the human brain, using T1-weighted MRI, diffusion tensor imaging and resting-state functional MRI. We will develop EEG methods to describe brain networks. From these data, we will identify candidate brain networks which generate seizures.

We will employ our successful phenomenological and physiological models of EEG, which capture the patterns of onset and evolution of human ictal EEG activity. We will adopt a novel formalism to investigate brain networks: generalized dynamic graphs with active network topology. We will combine forward modelling (physiological generative models), and backwards modelling (Bayesian inversion of generative models) to determine which candidate network is most likely to explain imaging and EEG observations.

We introduce the new concept of Brain Network Ictogenicity (BNI) - the propensity of brain networks to generate seizures. We will implement and further develop our novel approach to estimating BNI in real brain networks, based on combining a dynamic model with real network structures inferred from data.

In data from human patients with epilepsy, their relatives, and normal controls, we will investigate networks which generate seizures and the BNI of these networks. In appropriate subject groups, we will examine the familial basis of brain network properties; we will explain how a familial ictogenic network endophenotype may be further modified to allow seizures to be manifest; and we will reveal the network-level effects of successful drug treatment, natural remission and epilepsy surgery.

Planned Impact

(In accord with MRC guidance, this section emphasises impact for non-academic beneficiaries)

The new knowledge generated in the short-term by this Programme will bring benefits to a much wider group than only the academic community: a better understanding of brain network dynamics, and approaches to modelling such dynamics based on integrating data with dynamic models through the framework of generalised dynamic graphs with active network topology, will provide a novel approach to a range of brain diseases. This enhanced knowledge and new multidisciplinary methodological approach is likely to be of interest to commercial sector R&D, especially in the pharmaceutical industry and medical devices industry. For example, the ability to characterise the effects of a drug or neuromodulation device through parameter evolution of a generative model extracted from experimental or clinical data will be of benefit to commercial-sector pharmaceutical manufacturers, where they will be able to plan phase 3 trials to include data-derived prognostic biomarkers. This will be achieved using our platform to either develop their own generative models or use ours; such markers may become useful stratification markers or surrogate outcomes. Similarly, it may be possible to develop biomarkers of response to newly developed compounds in early-stage trials, based upon evolution of parameters of a suitable generative model. We have already taken steps to protect intellectual property through a patent application around the concept that changes over time in a phenomenological network model of EEG may predict clinical outcomes (joint patent application submitted by the University of Exeter and King's College London). These impacts could be felt early after the Programme completes.

The development of multidisciplinary researchers through this Programme will have an early impact which may extend for the length of the researchers' careers. The consequent enhancement of UK scientific competitiveness may be felt in academic and commercial sectors.

Science funding policy in the UK and worldwide increasingly emphasises collaboration between biomedicine and maths / engineering / computer science, but the development of such science would benefit from increasing multidisciplinary expertise and awareness amongst reviewers of funding proposals, and amongst funding panels and policy-makers. In the short term, we will seek to interact with funders to enhance the development of such multidisciplinarity.

We aim for a major impact within 5-10 years for patients with epilepsy and professionals providing healthcare in epilepsy. If successful, our framework will ultimately provide the opportunity both for a more definitive diagnosis and also more accurate prognosis for treatment response and remission. This will enable a rapid and definitive choice of treatment for patients, resulting in improvements to the health and quality of life of patients, reducing mortality and morbidity. This will be achieved through the uptake of our platform by experimental and clinical researchers, and the consequent filtering through of research findings into the clinic. For a new approach to be taken up in the clinic will require engagement with healthcare managers and policy-makers, which will be enabled through translational research following completion of the Programme.

In the short to medium term we intend an impact on public understanding of science, through public meetings we will hold throughout the duration of the programme.

Publications


10 25 50
 
Title Murmuration 
Description Murmuration is a unique partnership between three diverse disciplines to produce one unified artistic output. An individual's brainwaves will be recorded using an adapted Electroencephalographic (EEG) headset and transposed into a dynamic animation of flocking starlings. The flock's form and sound will change in response to the brain activity provoked by performing a set of cognitive tasks, giving the subject the sense of seeing and hearing their own brain activity as it happens. This project will be delivered through a collaboration of the Department of Basic and Clinical Neuroscience, Kings College London, the artist and designer Matthew Maxwell, and interactive architects Cinimod Studio and sound designers North V South to align biomedical research, contemporary art practice and software development. This alignment of science, art and technology will reveal aspects of neuroscience research methods in a compelling and beautiful form. The aim of this project is to engage and stimulate both the general public and epilepsy patients who have undergone EEG for research and clinical purposes. It will also provide a rare opportunity to convey, in an observable way, and to a wide and diverse audience, the complexity of brain activity and the unique ways it can be captured and understood. 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2015 
Impact The project application was unsuccessful. 
 
Title NHS Choices: Epilepsy and Research a short film 
Description King's College London Epilepsy Research group in collaboration with NHS choices are working with epilepsy patients and their family/carers tp produce a short film about epilepsy and research. 
Type Of Art Film/Video/Animation 
Year Produced 2016 
Impact This short video aims to engage the public about current research into epilepsy, what it is like to be diagnosed with and to live with epilepsy, and will be available on the NHS Choices website. 
 
Title Control subject EEG fMRI data set 
Description 25 EEG fMRI Control subject data sets available for anonymous sharing. Not made publicly available. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact No notable impacts as of yet. 
 
Title EEG Processing & Analysis: pipeline, scripts and toolbox functions 
Description EEG - Definition of Sets of Electrodes of Interest (EOI) - Initial data processing (pre-processing stage) - EEG data - real dimensionality - EEG presentation in Time-frequency domain (spectrograms) - Definition of Frequency intervals - Filtering in defined frequency bands - Synchrony analysis using 5 synchronisation models Models description: Phase locking factor - Undirected. Maximum normalised correlation (cross-covariance) - Undirected / Directed. Relative synchronisation speed - Directed. H2 - non-linear association index - Directed. - Definition of a set of basic structural network metrics - Inferring functional networks for each synchrony model and each frequency band - For each network calculate network measures - Statistical analysis of the results - in progress 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact none noted as of yet. 
 
Title IGE EEG patients and relatives database 
Description Scalp EEG data from 40 patients with IGE, 42 relatives and 35 normal control subjects, shared anonymously. Availability announced with publication of PMID: 25302690 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Publication 
 
Title Novel methods to quantify seizure generation in brain networks 
Description We have developed a neural mass model based framework with which to predict most efficacious sites for surgical resection in patients with pharmacologically resistant epilepsies 
Type Of Material Computer model/algorithm 
Provided To Others? No  
Impact We have already extended this framework into other models that enable faster computation of predictions. We have validated model predictions in patient datasets 
 
Title Preoperative EEG database from EFE patients who have undergone surgery 
Description Database of preoperative EEG data from EFE patients who have undergone surgery and have a known postoperative outcome. We have 40 postsurgical outcome cases who have undergone EEG ictal recording prior to resective surgery, and who have >1yr of postoperative follow-up. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact None as of yet. 
 
Title TLE EEG and fMRI patients and relatives database 
Description Scalp EEG and fMRI data from 21 patients and 12 relatives, shared anonymously with collaborative partners. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact no notable impacts at the present time. 
 
Title fMRI Network Analysis toolbox 
Description This is a MatLab based toolbox for analysing temporal changes of fMRI data during resting state. 
Type Of Material Data analysis technique 
Year Produced 2016 
Provided To Others? Yes  
Impact None noted as of yet. 
URL http://epilepsy-london.org
 
Description Bonn-Liverpool Collaboration 
Organisation Liverpool Hospital
Country Australia, Commonwealth of 
Sector Hospitals 
PI Contribution providing data and data analysis opportunities between the groups
Collaborator Contribution providing data and analysis methods, specifically neuroimaging applications.
Impact None yet.
Start Year 2014
 
Description Bonn-Liverpool Collaboration 
Organisation The Walton Centre NHS Foundation Trust
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution providing data and data analysis opportunities between the groups
Collaborator Contribution providing data and analysis methods, specifically neuroimaging applications.
Impact None yet.
Start Year 2014
 
Description Bonn-Liverpool Collaboration 
Organisation University of Bonn
Country Germany, Federal Republic of 
Sector Academic/University 
PI Contribution providing data and data analysis opportunities between the groups
Collaborator Contribution providing data and analysis methods, specifically neuroimaging applications.
Impact None yet.
Start Year 2014
 
Description Directed Influence Brain Network: Hangzhou Normal University Collaboration 
Organisation Hangzhou Normal University, China
Country China, People's Republic of 
Sector Academic/University 
PI Contribution providing data and data analysis opportunities to Hangzhou group.
Collaborator Contribution Providing analysis methods specifically, the development of an open-source MATLAB toolbox (Dynamic Brain Connectome) for tracking brain dynamics using functional MRI.
Impact None yet.
Start Year 2014
 
Description EEG modelling and source localisation: Geneva collaboration 
Organisation University of Geneva
Country Switzerland, Swiss Confederation 
Sector Academic/University 
PI Contribution Providing data and data analysis opportunities to Geneva group
Collaborator Contribution providing analysis methods, specifically (i) source localisation methods (ii) microstate analysis methods (iii) correlation between human data and rodent data
Impact Award of an Epilepsy Research UK grant £149,500 over 36 months, to carry out a project entitled 'An optimal computer model for the diagnosis and prognosis of focal epilepsies'.
Start Year 2014
 
Description Generative models for identifying seizure focus from stimulated intracranial EEG: University of Minnesota Collaboration 
Organisation University of Minnesota
Country United States of America 
Sector Academic/University 
PI Contribution providing data and data analysis opportunities to Minnesota group.
Collaborator Contribution Providing analysis methods, specifically algorithm to extract and classify feature from TMS EEG data, namely artefact rejection and support vector machine for multidimensional EEG data.
Impact None yet.
Start Year 2015
 
Description "Pint of science" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact "Pint of science": public engagement event presenting brain dynamics to a lay audience
Year(s) Of Engagement Activity 2014
 
Description American Epilepsy Society annual scientific meeting, Washington DC, 5-11 December 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Abstracts presented relating to MRC Programme:

2.178 HIPPOCAMPAL VOLUME AND POSTSURGICAL OUTCOME IN INTRACTABLE TEMPORAL LOBE EPILEPSY
Y. Goh, J. C. Schoene-Bake, A. Marson, M. P. Richardson, B. Weber, S. Keller

2.025 SUBCORTICAL ATROPHY IN PATIENTS WITH IGE AND THEIR ASYMPTOMATIC FIRST-DEGREE RELATIVES
M. P. Richardson, S. Keller, A. D. Pawley, L. Nashef, R. Elwes, F. Chowdhury

3.186 SUBCORTICAL SHAPE ANALYSIS IN TEMPORAL LOBE EPILEPSY
S. Keller, J. O Muircheartaigh, C. Traynor, K. Towgood, G. Barker, M. P. Richardson


Discussions with meeting par5ticipants
Year(s) Of Engagement Activity 2013
URL https://www.aesnet.org/sites/default/files/file_attach/Meeting/AES-2013program-bk_Washington%20DC_fi...
 
Description Biodynamics 2013 http://www.bio-dynamics2013.org/conference-programme.html 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact I led, facilitated and contributed to a session on Epilepsy in this meeting. Speakers were invited and costs covered through MRC funding. The programme of this section was:
Session 5a: Epilepsy

5a.1 Emergence of epileptogenic high frequency oscillations from human neuronal networks
M O Cunningham, Newcastle University, UK

5a.2 Peri-ictal dynamics of brain network synchronization
C Rummel, University Institute for Diagnostic and Interventional Neuroradiology,
Inselspital, Switzerland

5a.3 Investigating thalamocortical oscillations in man using MRI and EEG
A P Bagshaw, University of Birmingham, UK

5a.4 Large-scale brain models of epilepsy
M Richardson, King's College London, UK

Multicentre MRC grant proposal under discussion led by Cunningham.

Rummel and co-workers engaged in methods colalboration to benefit MRC Programme.

Bagshaw has invited me to present to Neuroimaging dept at Birmingham Unviersity.
Year(s) Of Engagement Activity 2013
URL http://www.bio-dynamics2013.org/conference-programme.html
 
Description Britain Needs Scientists presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Britain needs scientists: presentation on brain dynamics with the goal to inspire to inspire year 12 students to a career in science
Year(s) Of Engagement Activity 2014
 
Description Collaboration launch meeting: KCL, Exeter, University of Geneva - at KCL 1-2 September 2014 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Two-day meeting of research teams involved in MRC Programme and Epilepsy-EEG-imaging research group of University of Geneva (Profs Christoph Michel and Serge Vulliemoz. Extensive discussion of opportunities for data sharing, methods sharing and future research collaborations.

Two research proposals submitted in next 6 weeks, outcomes not yet known.
Year(s) Of Engagement Activity 2014
 
Description Collaboration launch meeting: KCL, University of Berne catalepsy imaging and EEG group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussions between KCL team involved in MRC Programme and group of Prof Kaspar Schindler. Presentation to internal university neuroscience meeting in Berne.

Plans for future collaboration, including hosting visit of Dr Eugenio Abela at KCl for 12 months, as part of MRC Programme (2016)
Year(s) Of Engagement Activity 2014
 
Description Collaboration launch meeting: KCL, University of Bonn epilepsy imaging group, University of Liverpool epilepsy imaging group 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Two day meeting with teams of Prof Bernd Weber (Bonn) and Dr Simon Keller (Liverpool) with team working in MRC Programme

Two papers in submission, using Bonn data to address aspects of Programme aims
Year(s) Of Engagement Activity 2014
 
Description European Congress on Epileptology 2014, Stockholm 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The following abstracts presented:

A voxel-based morphometry study of postoperative seizure outcome in temporal lobe epilepsy
Keller SS1,2, Richardson MP2, Schoene-Bake J-C3,4, Elger C3, Weber B3,4

Diffusion tensor imaging in Rolandic epilepsy
McGinnity CJ1, Tyson AL2, Gammerman A1, Gerbase SW3, Elmasri M4, Reed TK5, Said MA1, Pina M6, Barker GJ7, Smith AB1, Richardson MP1, Pal DK1

Simultaneous EEG-fMRI: posterior slow-waves compared with occipital alpha in childhood absence epilepsy
Perani S1,2, Centeno M2, Cross H2, Carmichael DW2, Richardson M1



Discussions with other participants in the meeting
Year(s) Of Engagement Activity 2014
URL http://www.epilepsystockholm2014.org/scientific-programme/interactive-scientific-programme.831.html
 
Description International day of woman and girls in science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Demonstration of a science experiment to girls from year 4 and 5. There were 4 experiments in total. Our's was about the concept of chemical reactions and involved mixing bicarbonate with different liquids found in the kitchen.
Year(s) Of Engagement Activity 2016
 
Description Invited Talk (SP) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Centre of Neuroimaging Science, King's College London, IoPPN

Title of talk: "studying idiopathic generalised epilepsy using simultaneous EEG-fMRI"
Year(s) Of Engagement Activity 2015
 
Description Organiser of: BrainModes international conference: Emergent dynamics from large scale brain networks in health and disease 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 100 people attended the Programme

Thursday 11th December: Methods for large-scale brain modelling

09.00 - 10.00 Registration and coffee

10.00 - 10.15 Welcoming remarks: Mark Richardson & John Terry

10.15 - 11.00 Karl Friston: Dynamic causal modelling and network discovery.

11.00 - 11.45 Klaus Lehnertz: Inferring and interpreting epileptic brain
networks from clinical data.

11.45 - 12.15 Orla Doyle: Application of pattern recognition in brain
networks.

12.15 - 13.45 Lunch

13.45 - 14.30 Petra Ritter: The virtual brain: A framework for collective
multimodal reverse engineering the brain.

14.30 - 15.15 Highlighted Oral

15.15 - 15.45 Coffee

15.45 - 16.30 Andreas Daffertshofer: talk title to be confirmed

16.30 - 17.15 Donald Tournier: Inferring structural connectivity using
diffusion MRI

17.30 - 19.00 Drinks reception

Friday 12th December: Applications

09.30 - 10.00 Coffee

10.00 - 10.45 Maxime Guye: Why are dynamics crucial for defining
connectivity alterations in epilepsy?

10.45 - 11.30 Tjeerd Boonstra: Intrinsic coupling modes in source
reconstructed electroencephalography.

11.30 - 12.00 Highlighted Talk

12.00 - 13.30 Lunch

13.30 - 14.15 Olivier David: Functional brain tractography.

14.15 - 15.00 Beatriz Rico: GABAergic circuitry assembly and schizophrenia.

15.00 - 15.30 Coffee

15.30 - 16.15 Emrah Duezel: Functional imaging of hippocampal networks
and their plasticity in old age.

16.15 - 17.00 John Pierre Lin: Towards a developmental and pathological
model of dsytonia in children: the influence of time, the timing of
deep brain stimulation and new information from brain imaging
intracerebral microelectrode recordings.

17.00 Thanks and close

(not yet known)
Year(s) Of Engagement Activity 2014
URL http://www.kcl.ac.uk/ioppn/depts/cn/brainmodes/index.aspx
 
Description Patient Focus Group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact A focus group event was conducted to consult with epilepsy patients on the contents, tone, visual style of a short video about whats involved when taking part in epilepsy research.
Year(s) Of Engagement Activity 2015
 
Description PhD Student Poster (SNY) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact King's College London Institute of Psychiatry, Psychology and Neuroscience Student Showcase, poster titled Altered Resting State Networks in Patients with JME
Year(s) Of Engagement Activity 2014
 
Description PhD Student Poster (SNY) 2 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact American Epilepsy Society Meeting 2015
Poster presentation - Altered Network Hubs in JME
Year(s) Of Engagement Activity 2015
 
Description Post-Doctoral Poster (CT) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation:

Title "Comparison between K-mean Clustering and Independent Component Analysis to extract
microstates from resting state EEG" by C. Tangwiriyasakul, A.D. Pawley, S.N. Yaakub, S. Carr and M. Richardson.

It was held at King's College London Neuroscience Symposium (Sep 10th, 2015).
Year(s) Of Engagement Activity 2015
 
Description Post-Doctoral Poster (GP) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact (IWSP) 7th Epilepsy Mechanisms, Models, Prediction & Control; poster presentation:

Seizure Dynamics, Network Topology and the Information Spread between different brain regions

Melbourne Brain Centre, University of Melbourne
Year(s) Of Engagement Activity 2015
 
Description Post-Doctoral Poster (GP) 2 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Bio Dynamics 2015- where Biology, Medicine & Mathematics meet poster presentation:

Network structure supports faster information flow between brain regions in people with idiopathic generalised epilepsy

John McIntyre Conference Centre, Edinburgh, UK
Year(s) Of Engagement Activity 2015
 
Description Post-Doctoral Poster (GP) 3 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Principles of autonomous neurodynamics 2014: Emergent Dynamics of Complex Biological Networks - oral presentation:

"A computational modelling approach for network structures in idiopathic generalised epilepsy"

Pasteur Institute; Paris; France
Year(s) Of Engagement Activity 2014
 
Description Post-Doctoral Poster (GP) 4 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Bio Dynamics Workshop 2014: Emergent Dynamics of Complex Biological Networks - poster presentation:

"A critical role for network structure in seizure onset: a computational modelling approach"

The Innovation Centre, University of Exeter, UK
Year(s) Of Engagement Activity 2014
 
Description Post-Doctoral Poster (ML) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Melbourne, IWSP7: Epilepsy Mechanisms, Models, Prediction and Control
Poster: "Forecasting epileptic seizures in neuronal networks".
Year(s) Of Engagement Activity 2015
 
Description Post-Doctoral Poster (ML) 2 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Brain States Conference: Characterization and Neuromodulation by DBS" (Cologne, Germany)

Poster: "Quantitative Analysis of Epileptic Brain Networks"
Year(s) Of Engagement Activity 2015
 
Description Sidmouth Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Sidmouth science festival: interaction/demo with adults and children on dynamics of the brain in health and disease
Year(s) Of Engagement Activity 2015