Coordinated transcriptional regulation patterns associated with infertility phenotypes in men. (2007)


Microarray gene-expression profiling is a powerful tool for global analysis of the transcriptional consequences of disease phenotypes. Understanding the genetic correlates of particular pathological states is important for more accurate diagnosis and screening of patients, and thus for suggesting appropriate avenues of treatment. As yet, there has been little research describing gene-expression profiling of infertile and subfertile men, and thus the underlying transcriptional events involved in loss of spermatogenesis remain unclear. Here we present the results of an initial screen of 33 patients with differing spermatogenic phenotypes.

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PubMed Identifier: 17496197

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Type: Journal Article/Review

Volume: 44

Parent Publication: Journal of medical genetics

Issue: 8

ISSN: 0022-2593