Nuclear organization in human sperm: preliminary evidence for altered sex chromosome centromere position in infertile males. (2008)

Abstract

Many genetic defects with a chromosomal basis affect male reproduction via a range of different mechanisms. Chromosome position is a well-known marker of nuclear organization, and alterations in standard patterns can lead to disease phenotypes such as cancer, laminopathies and epilepsy. It has been demonstrated that normal mammalian sperm adopt a pattern with the centromeres aligning towards the nuclear centre. The purpose of this study was to test the hypothesis that altered chromosome position in the sperm head is associated with male infertility.

Bibliographic Information

Digital Object Identifier: http://dx.doi.org/10.1093/humrep/den112

PubMed Identifier: 18417496

Publication URI: http://europepmc.org/abstract/MED/18417496

Type: Journal Article/Review

Volume: 23

Parent Publication: Human reproduction (Oxford, England)

Issue: 6

ISSN: 0268-1161